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Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 Proteins (CYP3A5)

CYP3A5,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP3A5 Antibodies (61) and CYP3A5 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CYP3A5 1577 P20815
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Top CYP3A5 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

CYP3A5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5) Interaction Partners

Human Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5) interaction partners

  1. pharmacokinetics of once-daily tacrolimus formulation in relation to polymorphisms of the donor cytochrome P450 family 3 sub-family A polypeptide 5 (CYP3A5) gene and recipient adenosine triphosphate-binding cassette sub-family B member 1 (ABCB1 (show ABCB1 Proteins)) gene in 80 consecutive living-donor liver transplant recipients

  2. CYP3A5 (6986A > G) genotype, rather than MDR-1 (2677G > A/T) variant, has an impact on tacrolimus pharmacokinetics

  3. SLCO1B1 (show SLCO1B1 Proteins) rs113681054, SLCO1B1 (show SLCO1B1 Proteins)*5 (rs4149056), CYP3A4 (show CYP3A4 Proteins)*1G (rs2242480), and CYP3A4 (show CYP3A4 Proteins)*5 (rs776746) polymorphisms had no effect on the PK/PD of ticagrelor in healthy Chinese volunteers

  4. study to determine the impact of CYP3A5 genetic polymorphisms on paclitaxel/carboplatin-induced myelosuppression and neurotoxicity in patients with epithelial ovarian cancer; found that CYP3A5*3*3 was associated with a lower risk of paclitaxel/carboplatin-induced myelosuppression compared with other CYP3A5 genotypes

  5. Liver transplant patients with CYP3A5 polymorphisms required significantly higher doses of tacrolimus to achieve target blood concentrations.

  6. CYP3A5 genetic polymorphisms in Uyghur population.

  7. The results suggest that early post-transplantation bioavailability differences in time to reach tacrolimus therapeutic levels are due to CYP3A5 genotype. This also appears to affect graft rejection and survival.

  8. Individual differences in metabolic clearance of risperidone under the present conditions were not significantly influenced by the genotypes of CYP2D6 (show CYP2D6 Proteins) or CYP3A5

  9. CYP3A5 and MDR1 polymorphisms may be the main explanation for the differences observed in RUP pharmacokinetics.

  10. that there was association between CYP3A5 FNx01 3 polymorphism and the altered risk of acute lymphoblastic leukemia in children, especially in Caucasian populations

CYP3A5 Protein Profile

Protein Summary

This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with CYP3A5

  • cytochrome P450, family 3, subfamily A, polypeptide 5 (CYP3A5)
  • CP35 protein
  • CYPIIIA5 protein
  • P450PCN3 protein
  • PCN3 protein

Protein level used designations for CYP3A5

cytochrome P450 3A5 , aryl hydrocarbon hydroxylase , cytochrome P450 HLp2 , cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5 , cytochrome P450-PCN3 , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase

737374 Pan troglodytes
1577 Homo sapiens
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