CYP3A5 Products
(Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 (CYP3A5))
Categories
This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2010].
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Featured CYP3A5 Categories
CYP3A5 Antibodies
High quality antibodies with extensive validation data.
CYP3A5 ELISA Kits
Reliable ELISA kits for a wide range of species.
CYP3A5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended CYP3A5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF
Validations
- (4)
Cat. No.
ABIN392224
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7149265
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (3)
Cat. No.
ABIN652394
Quantity
400 μL
Datasheet
Datasheet
Recommended CYP3A5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966252
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955260
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN2946890
Quantity
96 tests
Datasheet
Datasheet
Recommended CYP3A5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1350994
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3078139
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2712776
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our CYP3A5 products
: "Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, Issue 12, pp. 2221-30, (2012) (PubMed).: "Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects." in: Journal of clinical pharmacology, Vol. 47, Issue 1, pp. 87-93, (2006) (PubMed).
: "Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 33, Issue 7, pp. 1074-81, (2005) (PubMed).
: "Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 10, pp. 3758-65, (2005) (PubMed).
Synonyms and alternative names related to CYP3A5
cytochrome P450 family 3 subfamily A member 5 (CYP3A5), CP35, CYPIIIA5, P450PCN3, PCN3Protein level used designations for CYP3A5
- cytochrome P450 3A5
- aryl hydrocarbon hydroxylase
- cytochrome P450 HLp2
- cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
- cytochrome P450-PCN3
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- xenobiotic monooxygenase
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