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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Kits (18) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (8) and many more products for this protein.
Showing 10 out of 388 products:
Human Polyclonal DNMT1 Primary Antibody for FACS, WB - ABIN387878
Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003
Show all 7 references for ABIN387878
Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879
Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003
Show all 7 references for ABIN387879
Fish Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN361726
Bestor, Laudano, Mattaliano, Ingram: Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. in Journal of molecular biology 1989
Show all 6 references for ABIN361726
Human Polyclonal DNMT1 Primary Antibody for EIA, WB - ABIN356564
Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003
Show all 6 references for ABIN356564
Human Polyclonal DNMT1 Primary Antibody for DB - ABIN389901
Siedlecki, Garcia Boy, Comagic, Schirrmacher, Wiessler, Zielenkiewicz, Suhai, Lyko: Establishment and functional validation of a structural homology model for human DNA methyltransferase 1. in Biochemical and biophysical research communications 2003
Show all 5 references for ABIN389901
Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358447
Yang, Andrade, Labialle, Moussette, Geneau, Sinnett, Belisle, Greenwood, Naumova: Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families. in Genetics 2008
Show all 2 references for ABIN358447
Human Polyclonal DNMT1 Primary Antibody for DB - ABIN389917
Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. in International journal of cancer. Journal international du cancer 2008
Show all 2 references for ABIN389917
Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358462
Dion, Lin, Hubert, Waterland, Wilson: Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. in Human molecular genetics 2008
Show all 2 references for ABIN358462
Human Polyclonal DNMT1 Primary Antibody for IF (p), IHC (p) - ABIN671796
Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015
Dnmt1 stability requires UHRF1 (show UHRF1 Antibodies) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (show HELLS Antibodies) Is Essential for Maintaining Global DNA Methylation (show HELLS Antibodies) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Antibodies) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (show UHRF1 Antibodies) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Antibodies) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Antibodies) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
The inhibition of DNMT1 contributed to the activation of p53 (show TP53 Antibodies) pathways.
Results show that miR (show MLXIP Antibodies)-148a is down-regulated in urothelial cell carcinoma of the bladder cell lines. Its overexpression leads to induction of apoptosis in part by down-regulating DNMT1.
These data suggest that targeting the IL-8 (show IL8 Antibodies)/AKT1 (show AKT1 Antibodies) signaling pathway and DNMT1 may provide a potential therapeutic approach for blocking NPC (show NPC1 Antibodies) metastasis.
miR (show MLXIP Antibodies)-140-5p at least partly targets Dnmt1 and regulates SOD2 (show SOD2 Antibodies) expression to inhibit proliferation and promote apoptosis and differentiation of HPASMCs in hypoxia
Data indicate an epigenetic prognostic signature in glioblastomas based on expression of polycomb (show CBX2 Antibodies) repressive complex 2 (EZH2 (show EZH2 Antibodies)), DNA-methyltransferases DNMT1 and 3B which can be used easily in routine neuropathology practice.
the abundance of BDNF (show BDNF Antibodies) positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 (show FKBP4 Antibodies) in cells
miR (show MLXIP Antibodies)-124 and miR (show MLXIP Antibodies)-506 inhibit progression and increase sensitivity to chemotherapy by targeting DNMT3B (show DNMT3B Antibodies) and DNMT1 in colorectal carcinoma.
To correlate DNMTs expression with DNA methylation (show HELLS Antibodies), DNMT1, DNMT3A (show DNMT3A Antibodies) and DNMT3B (show DNMT3B Antibodies) mRNA levels in 5 colorectal cancer cell lines; results suggest that cellular DNMT expression is positively correlated with global DNA methylation (show HELLS Antibodies) level but not with regional DNA hypermethylation at each locus.
Phosphorylated p38 (show CRK Antibodies), DNMT1 and AChE were aberrantly expressed in a subset of hepatocellular carcinoma tumors.
We further demonstrate that such fibroblast activation is dependent on phosphate influx, aberrant phosphorylation of DNA methyltransferase DNMT1 and aberrant CpG island promoter methylation.
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (show NLRP5 Antibodies) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
Through down-regulating the expression of DNMT1, miR (show MYLIP Antibodies)-152 reduced Global DNA methylation (show HELLS Antibodies) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Antibodies) and Ppar gamma (show PPARG Antibodies).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Antibodies) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Antibodies), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (show VIM Antibodies) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Antibodies) and histone modification status in collaboration with MET1
VIM (show VIM Antibodies) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Antibodies) pathway.
Genetic studies indicate that the Polycomb (show CBX2 Antibodies) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (show HELLS Antibodies) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation (show HELLS Antibodies) but ectopic hypermethylation of genes previously marked by H3K27m3.
An intergenic nucleosome-free crossover hotspot 3a undergoes increased recombination activity in met1.
Cigarette smoke induces proteosomal-mediated degradation of DNMT1 in embryonic orofacial cells.
the abundance of BDNF (show BDNF Antibodies) positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 (show FKBP5 Antibodies) in cells
we suggest that 14-3-3 (show YWHAQ Antibodies) is a crucial reader of DNMT1pSer143 that regulates DNA methylation (show HELLS Antibodies) and altered gene expression that contributes to cell invasion
The replication foci targeting sequence domain, not the proliferating cell nuclear antigen (show PCNA Antibodies) - binding domain, is solely responsible for the replication-coupled DNA methylation (show HELLS Antibodies).
The expression of DNMT1 and DNMT3b (show DNMT3B Antibodies) was decreased at 1 mT, and 50 Hz ELF (show SPTBN1 Antibodies)-EMF can increase the expression...the alterations of genome-wide methylation and DNMTs expression may play an important role in the biological effects of 50 Hz ELF (show SPTBN1 Antibodies)-EMF exposure
Data suggest Fabp4 (show FABP4 Antibodies) is up-regulated and DNA methylation (show HELLS Antibodies) is down-regulated in aorta in hyperhomocysteinemia induced by high-methionine diet; up-regulation of DNA methyltransferase 1 (Dnmt1) promotes DNA methylation (show HELLS Antibodies) and decreases Fabp4 (show FABP4 Antibodies) expression.
Obesity-induced, pro-inflammatory cytokines promote DNMT1 expression and its hypermethylation of the adiponectin (show ADIPOQ Antibodies) promoter, suppressing adiponectin (show ADIPOQ Antibodies) expression and exacerbating insulin (show INS Antibodies) resistance.
Dnmt1 is indispensable for mammary stem cell and mammary cancer stem cell maintenance, and for mammary tumorigenesis. Dnmt1 hypermethylates and downregulates ISL1 (show ISL1 Antibodies) in mammary tumors and cancer stem cells.
The hypermethylation of KLF4 (show KLF4 Antibodies) directly mediated by Dnmt1 contributes to the progression of EMT (show ITK Antibodies) in renal epithelial cells.
the presence of DNMT1 in adult neural stem/precursor cells is crucial for the survival of newly generated neurons, but is dispensable once they accomplish neuronal differentiation in the adult hippocampus.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI