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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (255) and DNMT3A Proteins (7) and many more products for this protein.
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Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 ELISA Kits), Dnmt3a, Hdac1 (show HDAC1 ELISA Kits), Kdm3a (show KDM3A ELISA Kits) and Uhrf1 (show UHRF1 ELISA Kits) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
miR (show MLXIP ELISA Kits)-29b was negatively correlated with DNMT3A/3B expression at the cellular/histological levels.
mRNA and protein expression levels of DNMT3a were upregulated in genotype 1b and 3a HCV-infected hepatocellular carcinoma patients as compared to control. No differences were seen for genotypes 5 and 7.
These results suggested that miR200b has an important role in hepatocarcinogenesis and acts by downregulating DNMT3a expression.
Overexpression of DNMT3A is associated with Hepatocellular Carcinoma.
Our meta-analysis suggested that DNMT1 (show DNMT1 ELISA Kits) rs16999593 and DNMT3A rs1550117 could contribute to GC and that DNMT3B (show DNMT3B ELISA Kits) rs1569686 might function as a protective factor against gastric carcinogenesis.
Down-regulation of DNMT3A promotes cell proliferation and invasion of ectopic endometrial stromal cells in adenomyosis.
DNMT3A R882 mutations possessed significant unfavorable prognostic influence on Relapse-free survival and Overall survival in Acute Myeloid Leukemia (show BCL11A ELISA Kits) patients.
Expression of miR (show MLXIP ELISA Kits)-26a and miR (show MLXIP ELISA Kits)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 ELISA Kits), ATP1B1 (show ATP1B1 ELISA Kits), COL4A2 (show COL4a2 ELISA Kits), CPEB3 (show CPEB3 ELISA Kits), CDK6 (show CDK6 ELISA Kits), DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
DNMT3A polymorphism plays a major role in the pathogenesis of late-onset Alzheimer's disease and can be used as a stratification marker to predict an individual's susceptibility.
We suggest that 2p23 microdeletion including DNMT3A may cause similar symptoms in patients with DNMT3A mutations and should be considered in patients with overgrowth.
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS ELISA Kits) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 ELISA Kits) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 ELISA Kits) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B ELISA Kits) were associated with several beef quality traits.
Dnmt3a is a haplo-insufficient (show TGFb ELISA Kits) tumor suppressor in chronic lymphocytic leukemia and highlights the importance of deregulated molecular events in disease pathogenesis.
Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.
The stress-induced Brg1 (show SMARCA4 ELISA Kits)-G9a (show EHMT2 ELISA Kits)/GLP (show GOLGA6A ELISA Kits)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 ELISA Kits) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML ELISA Kits)-RARA (show RARA ELISA Kits)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML ELISA Kits) (APL (show FASL ELISA Kits)) required DNMT3A
Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B ELISA Kits) mRNA transcripts.
An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B ELISA Kits).
knock-outs display loss of DNA methylation (show HELLS ELISA Kits) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells
These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS ELISA Kits) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA