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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (253) and DNMT3A Proteins (7) and many more products for this protein.
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Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 ELISA Kits), Dnmt3a, Hdac1 (show HDAC1 ELISA Kits), Kdm3a (show KDM3A ELISA Kits) and Uhrf1 (show UHRF1 ELISA Kits) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT3A is frequently mutated in T-ALL and is associated with distinct clinicopathologic entities and a poor prognosis.
findings suggest that mutations in the DNMT3A gene can only be used as a biomarker for those AML (show RUNX1 ELISA Kits) patients in whom DNMT3A mutation is lost after therapy
The HBVX gene upregulated the mRNA and protein expression levels of DNMT3A/3B, downregulated the expression of SOCS1 (show SOCS1 ELISA Kits) and increased SOCS1 (show SOCS1 ELISA Kits) gene promoter CpG island methylation.
DNMT3a is a direct target of miR143.
These results suggest that DNMT3A R882(mut), particularly when accompanied by FLT3-ITD(pos), is a significant prognostic factor for inferior transplantation survival outcome by increasing relapse risk, even after allogeneic HCT
Our findings demonstrated a significant association between DNMT3A rs1550117 A>G polymorphism and increased risk of cancer in three genetic models. Meta-analysis.
DNMT3A mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells in Acute myeloid leukemia (show BCL11A ELISA Kits) patients.
DNMT3A R882 mutation is associated with elevated expression of MAFB (show MAFB ELISA Kits) and M4/M5 immunophenotype of acute myeloid leukemia (show BCL11A ELISA Kits) blasts.
DNMT3A mutants can block the differentiation of HSCs and leukaemic cells via PRC1 (show PRC1 ELISA Kits).
DNMT3A mutation was a poor prognostic factor in MLL (show MLL ELISA Kits)-partial tandem duplication Acute myeloid leukemia (show BCL11A ELISA Kits).
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS ELISA Kits) content are rather a function of time, and not a genetic component.
The effect of p53 (show TP53 ELISA Kits) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 ELISA Kits) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (show DNMT3B ELISA Kits) were associated with several beef quality traits.
Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.
The stress-induced Brg1 (show SMARCA4 ELISA Kits)-G9a (show EHMT2 ELISA Kits)/GLP (show GOLGA6A ELISA Kits)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 ELISA Kits) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML ELISA Kits)-RARA (show RARA ELISA Kits)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML ELISA Kits) (APL (show FASL ELISA Kits)) required DNMT3A
Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B ELISA Kits) mRNA transcripts.
An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B ELISA Kits).
knock-outs display loss of DNA methylation (show HELLS ELISA Kits) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells
These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS ELISA Kits) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.
data suggest that Dnmt3a and Dnmt3b (show DNMT3B ELISA Kits) are critical to regulate the onset of Igkappa light chain rearrangement during early B-cell development
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA