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This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Additionally we are shipping DNMT3A Antibodies (10) and many more products for this protein.
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Dnmt3a is a haplo-insufficient (show TGFb ELISA Kits) tumor suppressor in chronic lymphocytic leukemia and highlights the importance of deregulated molecular events in disease pathogenesis.
Cigarette smoke induces proteosomal-mediated degradation of DNMT3a in embryonic orofacial cells.
The stress-induced Brg1 (show SMARCA4 ELISA Kits)-G9a (show EHMT2 ELISA Kits)/GLP (show GOLGA6A ELISA Kits)-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 (show MYH6 ELISA Kits) promoter illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals.
both the PML (show PML ELISA Kits)-RARA (show RARA ELISA Kits)-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML ELISA Kits) (APL (show FASL ELISA Kits)) required DNMT3A
Overexpression or knockdown of medial prefrontal cortex Dnmt3a levels decreases or increases anxiety-like behavior, respectively.
DKO cardiomyocytes showed virtual absence of targeted Dnmt3a and Dnmt3b (show DNMT3B ELISA Kits) mRNA transcripts.
An unexpected oncogenic role for Dnmt3a in MTCL through methylation-independent repression of Dnmt3b (show DNMT3B ELISA Kits).
knock-outs display loss of DNA methylation (show HELLS ELISA Kits) at transcriptional start site of long non-coding RNAs enriched in hematopoietic stem cells
These results indicated a role for the miR29b-Dnmt3a/3b-DNA methylation (show HELLS ELISA Kits) axis in mouse early embryonic development, and we provide evidence that miR29b is indispensable for mouse early embryonic development
Our results suggest that DNMT3A mutations and oncogenic RAS cooperate to regulate hematopoietic stem and progenitor cells and promote myeloid malignancies.
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
DNA (cytosine-5)-methyltransferase 3A
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA
, DNA methyltransferase 3A