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Frataxin (FXN) ELISA Kits

This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. Additionally we are shipping Frataxin Antibodies (137) and Frataxin Proteins (23) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FXN 2395 Q16595
FXN 499335  
FXN 14297 O35943
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Top Frataxin ELISA Kits at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.055 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$757.89
Details
Human 5.8 pg/ml 23.5-1500 pg/mL   96 Tests Log in to see 11 to 13 Days
$910.56
Details
Rat
  96 Tests Log in to see 11 to 13 Days
$875.60
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Cow
  96 Tests Log in to see 11 to 13 Days
$1,029.60
Details

More ELISA Kits for Frataxin Interaction Partners

Fruit Fly (Drosophila melanogaster) Frataxin (FXN) interaction partners

  1. Frataxin overexpression in the nervous system reduces life span, impairs locomotor ability and causes brain degeneration.

  2. Strong involvement of glial cells and lipid peroxidation in the generation of Friedreich's ataxia (show USP14 ELISA Kits).

  3. Defects in axonal transport of mitochondria appear late in development in distal nerve of larvae showing reduced frataxin expression, with retrograde movement preferentially affected.

  4. H2O2 is an important pathogenic substrate underlying the phenotypes arising from frataxin deficiency in Drosophila

  5. This suggests that Drosophila frataxin may function to protect the mitochondria from oxidative stresses and the ensuing cellular damage.

  6. Dfh-assisted assembly of Fe-S clusters occurs with an observed kinetic rate constant ( k obs (show LEP ELISA Kits)) of 0.096 min (-1 (show CD59 ELISA Kits))

Human Frataxin (FXN) interaction partners

  1. In compound heterozygotes, expression of partially functional mutant frataxin delays age of onset and reduces diabetes mellitus, compared to those with no frataxin expression from the non-expanded allele.

  2. FXN promoter function was directly measured via metabolic labeling of newly synthesized transcripts in fibroblasts, which revealed that the YG8sR mouse was significantly deficient in transcriptional initiation compared to the Y47R mouse.

  3. Thus, Src (show SRC ELISA Kits) inhibitors emerge as a new class of drugs able to promote frataxin accumulation, suggesting their possible use as therapeutics in Friedreich's Ataxia (show USP14 ELISA Kits)

  4. Engineered a cell line where the presence of an exogenous, inducible FXN gene rescues the cells from the knockout of the two endogenous FXN genes. This system allows the possibility of testing the progression of disease.

  5. The region of chromosome 9 carrying the FXN gene is prone to chromosomal rearrangements in both control and Friedreich ataxia patient cells.

  6. Expanded GAA (show GAA ELISA Kits) repeats impair FXN gene expression and reposition the FXN locus to the nuclear lamina in single cells

  7. Findings confirm a detrimental effect of frataxin silencing, not only for astrocytes, but also for neuron-glia interactions, underlining the need to take into account the role of non-cell autonomous processes in Friedreich's ataxia (show USP14 ELISA Kits).

  8. We propose a model of premature termination of FXN transcription induced by pathogenic expanded GAA (show GAA ELISA Kits) repeats that links R-loop structures, antisense transcription, and heterochromatin formation

  9. Patients with a FXN p.R165P missense mutation progress to a less disabling disease state than typical Friedreich ataxia patients

  10. FXN accelerates a rate-limiting sulfur transfer step in the synthesis of [2Fe-2S] clusters on the human Fe-S assembly complex.

Mouse (Murine) Frataxin (FXN) interaction partners

  1. Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34

  2. Frataxin-deficient mice, which had higher mitochondrial iron loading, showed impaired airway mucociliary clearance and higher pulmonary inflammation at baseline.

  3. Using a mouse model of hepatic FXN deficiency in combination with mice deficient for IRP1 (show ACO1 ELISA Kits), a key regulator of cellular iron metabolism, we show that IRP1 (show ACO1 ELISA Kits) activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool

  4. The Fxn KO/Mck (show CKM ELISA Kits) mice tested from one to two months of age showed abnormal gait patterns accompanied by a loss in motor skills

  5. Reduced expression of frataxin in Friedreich's ataxia (show USP14 ELISA Kits) leads to elevation of COX2 (show COX2 ELISA Kits)-mediated oxylipin synthesis stimulated by increases in transcription factors that respond to increased reactive oxygen species.

  6. Frataxin-deficient cells showed a specific inhibition of mitochondrial Complex I activity already at 70% residual frataxin levels, whereas the glutathione imbalance progressively increased after silencing.

  7. The results support a mechanistic hypothesis in which frataxin deficiency decreases Nrf2 expression in vivo, causing the sensitivity to oxidative stress in target tissues the DRG and the cerebella, which contributes to the process of neurodegeneration.

  8. rescue of the Friedreich ataxia knockout mutation in transgenic mice containing an FXN-EGFP genomic reporter

  9. these results indicate that IGF-I (show IGF1 ELISA Kits) exerts cell-context neuroprotection in frataxin deficiency that maybe therapeutically effective.

  10. Data show that the respiratory chain defects accompanying frataxin deficiency cause progressive hyperacetylation of cardiac mitochondrial proteins due to the inhibition of SIRT3 (show SIRT3 ELISA Kits) deacetylase.

Frataxin (FXN) Antigen Profile

Antigen Summary

This nuclear gene encodes a mitochondrial protein which belongs to FRATAXIN family. The protein functions in regulating mitochondrial iron transport and respiration. The expansion of intronic trinucleotide repeat GAA results in Friedreich ataxia. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Frataxin (FXN) ELISA Kits

  • frataxin (fxn) antibody
  • frataxin (LOC100284365) antibody
  • frataxin (TVAG_182150) antibody
  • frataxin homolog (fh) antibody
  • frataxin (FTX1) antibody
  • frataxin (FXN) antibody
  • frataxin (Fxn) antibody
  • BcDNA:AT09528 antibody
  • CG8971 antibody
  • CyaY antibody
  • dfh antibody
  • Dmel\\CG8971 antibody
  • FA antibody
  • FARR antibody
  • Frda antibody
  • LOC100284365 antibody
  • RGD1565754 antibody
  • X25 antibody
  • zgc:158218 antibody

Protein level used designations for Frataxin (FXN) ELISA Kits

DKEYP-118A9.1 , frataxin, mitochondrial , frataxin , CG8971-PA , CG8971-PB , fh-PA , fh-PB , frataxin homologue , frataxin-like , Friedreich ataxia protein , Friedreich ataxia

GENE ID SPECIES
556389 Danio rerio
100284365 Zea mays
5468558 Trichomonas vaginalis G3
31845 Drosophila melanogaster
5718448 Chlamydomonas reinhardtii
2395 Homo sapiens
499335 Rattus norvegicus
14297 Mus musculus
505694 Bos taurus
427244 Gallus gallus
609051 Canis lupus familiaris
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