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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Additionally we are shipping Metabotropic Glutamate Receptor 1 Antibodies (142) and Metabotropic Glutamate Receptor 1 Kits (14) and many more products for this protein.
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Missense Mutation in GRM1 gene is associated with Spinocerebellar Ataxia Type 44.
our findings suggest that pharmacological manipulation of mglur1 should be explored as an exciting new approach for the treatment of a variety of human cerebellar ataxias.
a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1 (show TRMT1 Proteins), both of which were found to co-segregate with the intellectual disability.
It has the intrinsic ability to form a heteromeric complex with adenosine A1 receptor and mutually modulate signaling.
These data demonstrate that the approaches commonly used to study mGlu1 receptor function and signaling in other systems may be inappropriate for studying mGlu1 receptor-mediated melanoma cell viability.
Our results are likely relevant to human breast cancer, highlighting a putative role of mGluR1 in the pathophysiology of breast cancer and the potential of mGluR1 as a novel therapeutic target.
elevated glutamate (show GRIN1 Proteins) secretion and mGluR1 expression play a role in Kaposi's sarcoma associated herpesvirus induced cell proliferation
alpha-actinin-4 (show ACTN4 Proteins) is a novel group 1 mGluR (show GRM8 Proteins)-interacting partner that orchestrates spine dynamics and morphogenesis in neurons.
Deleterious GRM1 mutations are associated with schizophrenia.
These novel mutations may contribute to the disease by alterations in GRM1 gene splicing, receptor activation, and post-receptor downstream signaling.
The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture.
This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 (show GRM5 Proteins) from hippocampal tissue.
results demonstrate that mGluR1 is crucial for the visual-experience-dependent maintenance of mature synaptic connectivity in the dorsal Lateral Geniculate Nuc.
These results suggest that impairment of synaptic mGluR cascades is one of the important contributing factors to cerebellar ataxia in early and middle stages of spinocerebellar ataxia type 1 (SCA1) pathology, and that modulation of mGluR signalling by baclofen or other clinical interventions may be therapeutic targets to treat SCA1
activation of mGluR1 expressed by OCCM (show LAMC3 Proteins)-30 cells induces cell proliferation in a manner that is dependent on mitogen-activated protein kinase (show MAPK1 Proteins) pathways.
In a mouse model of human spino (show PPP1R9B Proteins)-cerebellar ataxia type 1 (early SCA1 (show ATXN1 Proteins), 12 weeks) we find prolonged parallel fiber mGluR1-dependent synaptic currents and calcium signaling
Here we identify mGluR1 and mGluR5 (show GRM5 Proteins) as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN (show TNPO1 Proteins). Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain.
data suggest that Lys (show LYZ Proteins)(63)-linked polyubiquitination is involved in the ligand-mediated endocytosis of mGluR1.
This study provides evidence that ASIC1a (show ACCN2 Proteins) is involved in group I metabotropic glutamate (show GRIN1 Proteins) (mGlu) receptor-induced increase in action potential firing.
Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate (show GRIN1 Proteins) receptor
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions.
metabotropic glutamate receptor 1
, metabotropic glutamate receptor A
, G protein coupled receptor, family C, group 1, member A
, G protein-coupled receptor, family C, group 1, member A
, G protein coupled receptor family C group 1 member A