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anti-Guanylate Cyclase, beta (GUCYB) Antibodies

GUCYB encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GUCYB 230103 Q6VVW5
GUCYB 4882 P20594
GUCYB 116564 P16067
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Top anti-Guanylate Cyclase, beta Antibodies at

Showing 3 out of 4 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HuvEc cells, using Guanylate Cyclase beta Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Guanylate Cyclase beta Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg Log in to see 3 to 4 Days
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 9 to 14 Days

GUCYB Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine)


Rat (Rattus)

More Antibodies against Guanylate Cyclase, beta Interaction Partners

Mouse (Murine) Guanylate Cyclase, beta (GUCYB) interaction partners

  1. NPR2 (show NPRL2 Antibodies) is involved in FSH (show BRD2 Antibodies)-mediated oocyte meiotic resumption, and this process is associated with the EGFR (show EGFR Antibodies) and MAPK3 (show MAPK3 Antibodies)/1 signaling pathways.

  2. NPR2 (show NPRL2 Antibodies) dephosphorylation in the mural granulosa cells is essential for the normal progression of meiosis in response to LH and EGF receptor (show EGFR Antibodies) activation.

  3. Npr2 (show NPRL2 Antibodies) is necessary for the precise spatial organization typical of central auditory circuits, but signals are still transmitted with normal timing, and that mutant mice can hear even with these deficits.

  4. Npr2 (show NPRL2 Antibodies) is expressed in hard calluses of wild-type mice, suggesting a possible role of CNP (show CNP Antibodies) signaling in fracture repair, especially in bone remodeling stage.

  5. Data, including data from mutant mice strain Npr2 (show NPRL2 Antibodies)(slw/slw), suggest that Npr2 (show NPRL2 Antibodies) is critical for fertility but role of Npr2 (show NPRL2 Antibodies) may be more involved in penile function rather than involved in spermatogenesis.

  6. These findings demonstrate that pNPPB may be used as a probe to identify the essential amino acid sequences for activation of NPR2 (show NPRL2 Antibodies).

  7. GATA2 (show GATA2 Antibodies) and Lmo2 (show LMO2 Antibodies) cooperatively regulate VEGF (show VEGFA Antibodies)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 Antibodies).

  8. Data suggest that epidermal growth factor (Egf)/Egf (show EGF Antibodies) receptor (show EGFR Antibodies) signaling in cumulus cells (CC) down-regulates Npr2 (show NPRL2 Antibodies), decreases cGMP, elevates calcium, and induces meiotic resumption/oogenesis in cultured CC-oocyte complexes (in induced meiotic arrest).

  9. CNP (show CNP Antibodies)/NPR2 (show NPRL2 Antibodies) signaling is essential for oocyte meiotic arrest in early antral follicles and activated LH/amphiregulin (show AREG Antibodies)/EGFR (show EGFR Antibodies) signaling pathway suppresses this signal by downregulating Nppc (show NPPC Antibodies) expression.

  10. NPPC (show NPPC Antibodies)/NPR2 (show NPRL2 Antibodies) signaling is essential for oocyte meiotic arrest and cumulus oophorus formation, which affects female fertility through the production of oocytes with developmental capacity.

Human Guanylate Cyclase, beta (GUCYB) interaction partners

  1. Mutations in three genes (GDF5 (show GDF5 Antibodies), NPR2 (show NPRL2 Antibodies), BMPR1B (show BMPR1B Antibodies)) have been reported to cause different forms of acromesomelic dysplasia

  2. IL1R2 (show IL1R2 Antibodies) hypomethylation and androgen receptor (show AR Antibodies) hypermethylation may constitute an important determinant of disease severity, whereas NPR2 (show NPRL2 Antibodies) hypomethylation and SP140 (show SP140 Antibodies) hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea

  3. Loss-of-function mutations of the NPR2 (show NPRL2 Antibodies) gene is associated with acromesomelic dysplasia, type maroteaux.

  4. NPR2 (show NPRL2 Antibodies) mutations account for approximately 3% of patients with disproportionate short stature and/or clinical or radiographic indicators of SHOX (show SHOX Antibodies) deficiency and in whom no SHOX (show SHOX Antibodies) defect has been identified.

  5. 3 consanguineous families segregating Acromesomelic dysplasia Maroteaux type in an autosomal recessive manner studied. Linkage in the families was established to the NPR2 (show NPRL2 Antibodies) gene on chromosome 9p12-21. Sequence analysis revealed 2 novel missense variants (p.Arg601Ser; p.Arg749Trp) in 2 families and a previously reported splice site variant (c.2986+2T>G) in the third family.

  6. Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A (show NPR1 Antibodies)/-B activator.

  7. Gene expression of C-type natriuretic peptide (show NPPC Antibodies) and of its specific receptor NPR-B (show NPR2 Antibodies) in human leukocytes of healthy and heart failure subjects

  8. Molecular dynamics analysis indicated decreases in the values of Van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Waals, electrostatic energy and potential energy of NPRB (show NPR2 Antibodies)/Vasonatrin peptide compared to NPRA (show NPR1 Antibodies)/Vasonatrin peptide.

  9. Identification of heterozygous dominant negative NPR2 (show NPRL2 Antibodies) mutations in 2% of Japanese patients with short stature.

  10. KIdney NPR2 (show NPRL2 Antibodies) protein quantity is significantly impacted by genetic variation.

Guanylate Cyclase, beta (GUCYB) Antigen Profile

Protein Summary

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Gene names and symbols associated with GUCYB

  • natriuretic peptide receptor 2 (Npr2) antibody
  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (NPR2) antibody
  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (Npr2) antibody
  • AMDM antibody
  • ANPb antibody
  • ANPRB antibody
  • cn antibody
  • GC-B antibody
  • GC-B2 antibody
  • GC-B3 antibody
  • GUC2B antibody
  • GUCY2B antibody
  • mNPR-B antibody
  • NPR-B antibody
  • NPRB antibody
  • NPRBi antibody
  • pwe antibody

Protein level used designations for GUCYB

ANP-B , ANPR-B , NPR-B , Nppb receptor , atrial natriuretic peptide receptor 2 , atrial natriuretic peptide receptor type B , guanylate cyclase B , guanylyl cyclase-B , natriuretic peptide receptor B type , GC-B , atrial natriuretic peptide B-type receptor , ANPRB , atrial natriuretic peptide receptor B , natriuretic peptide receptor 2 , natriuretic peptide receptor-B

230103 Mus musculus
4882 Homo sapiens
116564 Rattus norvegicus
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