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The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Antibodies (195) and Hepatitis A Virus Cellular Receptor 2 Proteins (36) and many more products for this protein.
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The Tim-3/Gal-9 (show LGALS9 ELISA Kits) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
this study shoes that Tim-3 level is significantly upregulated in monocytes from gastric cancer patients compared with those from healthy controls
these results suggest that TIM3 is a novel therapeutic target and prognostic biomarker for esophageal squamous cell carcinoma (ESCC) and promotes metastasis of ESCC by inducing epithelial-mesenchymal transition via, at least partially, the Akt (show AKT1 ELISA Kits)/GSK-3beta/Snail (show SNAI1 ELISA Kits) signaling pathway.
Tim-3 facilitates osteosarcoma proliferation and metastasis through the NF-kappaB (show NFKB1 ELISA Kits) pathway and epithelial-mesenchymal transition.
Studied the associations of T-cell immunoglobulin and mucin (show SLC13A2 ELISA Kits) domain-3 (Tim-3) polymorphisms and the alternate reading frame protein (F protein (show HPD ELISA Kits)) with the outcomes of HCV infection; findings suggest that the rs12186731 CT and rs13170556 TC/CC genotypes of Tim-3 provide potential protective effects with the F protein (show HPD ELISA Kits) in the outcomes of HCV infection and that these effects are related to sex and age.
this study shows that the levels of expression of TIM-3 on CD4 (show CD4 ELISA Kits)+ T cells, CD8 (show CD8A ELISA Kits)+ T cells, CD56 (show NCAM1 ELISA Kits)+ T cells and in serum in patients with systemic lupus erythematosus are significantly higher than those of healthy controls
ovarian tumor-infiltrating Treg cells were more immunosuppressive than their peripheral blood counterparts in a TIM3-dependent fashion.
T cell immunoglobulin and mucin (show SLC13A2 ELISA Kits) domain-containing molecule 3 might participate in the progression of type 2 diabetes by its negative regulation on immune cells, and Tim-3 on CD14 (show NDUFA2 ELISA Kits)(+) monocytes serves as a novel biological marker for diabetes duration in type 2 diabetes patients.
Increased Tim3 expression is associated with renal cell carcinoma.
Hepatitis B virus surface antigen stimulation of human, monocyte-derived dendritic cells increases expression of Tim-3.
miR (show MLXIP ELISA Kits)-330-5p has a strong inhibitory effect on TIM-3 expression in acute myeloma leukaemia cell line
Methylation level of the TIM-3 promoter gradually decreased after each round of T-cell polarization, and this decrease was inversely correlated with TIM-3 expression.
in mice, TIM-3 is not essential for development of HDM (show HDAC3 ELISA Kits)-induced acute or chronic allergic airway inflammation, although it appears to be involved in reduced lymphocyte recruitment during HDM (show HDAC3 ELISA Kits)-induced chronic allergic airway inflammation.
Authors found that a CD8 (show CD8A ELISA Kits)(+) T-cell population with age-associated exhaustion was distinguishable by its expression of Tim-3.
TIM4 (show TIMD4 ELISA Kits) binds TIM3 on the surface of polarized Th1 (show HAND1 ELISA Kits) cells to induce Th1 (show HAND1 ELISA Kits) cell apoptosis, which may contribute to the development of Th2-dominant immune disorders.
The Gal-9 (show LGALS9 ELISA Kits)/Tim-3 signal is important for the regulation of decidua NK cells function, which is beneficial for the maintenance of a normal pregnancy.
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN ELISA Kits) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A ELISA Kits) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.
TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A ELISA Kits)-dependent manner.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog