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The protein encoded by HAVCR2 belongs to the immunoglobulin superfamily, and TIM family of proteins. Additionally we are shipping Hepatitis A Virus Cellular Receptor 2 Antibodies (155) and Hepatitis A Virus Cellular Receptor 2 Proteins (29) and many more products for this protein.
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The Tim-3/Gal-9 (show LGALS9 ELISA Kits) pathway might link disease progression with T cell exhaustion during bovine leukemia virus infection.
Tim-3 in primary leukocytes, both healthy and malignant AML cells, displays moderate properties of an inflammatory receptor with additional growth factor (mTOR activation) and pro-angiogenic (VEGF release) activities
Tim-3 played an important role in the development and progression of gastric cancer, and it could be used as an independent prognostic factor for gastric cancer patients.
an abnormal Tim-3/Gal-9 (show LGALS9 ELISA Kits) pathway was able to facilitate the development of preeclampsia.
sTim-3 was involved in the development of sepsis. The homeostasis-promoting role of the Tim-3 on the monocytes was disrupted, while the inhibitory role of sTim-3 emerged during sepsis-induced immunosuppression.
decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of systemic lupus erythematosus.
Results indicate that upregulation of the inhibitory receptor Tim-3 may restrict T cell responses in CRC (show CALR ELISA Kits) patients.
TIM-3 is a negative regulator of TCR-function by attenuating activation signals mediated by CD3 (show CD3 ELISA Kits)/CD28 (show CD28 ELISA Kits) co-stimulation.
Tim-3 might participate in the tumorgenesis of colon cancer and Tim-3 expression might be a potential independent prognostic factor for patients with colorectal cancer.
TIM-3 polymorphism is associated with increased susceptibility to osteoarthritis.
TIM-3 and its ligand, galectin-9 (Gal-9 (show LGALS9 ELISA Kits)), constitute an autocrine loop critical for leukemic stem cells self-renewal and development of human acute myeloid leukemia (show BCL11A ELISA Kits).
TIM-3 expression by NK cells and gamma/delta T cells is similar in the peripheral and decidual immune cells from pregnant mice.
Tim-3 acts at a receptor-proximal point to enhance Lyn (show LYN ELISA Kits) kinase-dependent signaling pathways that modulate both immediate-phase degranulation and late-phase cytokine production downstream of FcepsilonRI (show FCER1A ELISA Kits) ligation.
Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer
TIM-3 plays a role in regulating the uterine natural killer cells and contributes to the maintenance of tolerance at the feto-maternal interface.
TIM-3 is highly expressed in hypoxic brain regions of a mouse cerebral hypoxia-ischaemia (H/I) model. TIM-3 is distinctively upregulated in activated microglia and astrocytes in a HIF-1 (show HIF1A ELISA Kits)-dependent manner.
These data identify an IL-27 (show IL27 ELISA Kits)/NFIL3 (show NFIL3 ELISA Kits) signalling axis as a key regulator of effector T-cell responses via induction of Tim-3, IL-10 (show IL10 ELISA Kits) and T-cell dysfunction.
CD4 (show CD4 ELISA Kits)+ T cell-dependent "negative" TIM-3 costimulation is essential for hepatic homeostasis and resistance against IR stress in OLTs
In DSS (show PMP22 ELISA Kits) colitis, Tim-3 inhibited the polarization of pathogenic pro-inflammatory M1 macrophages, while Tim-3 downregulation or blockade resulted in an increased M1 response. Tim-3 effect on macrophage response may be TLR4 (show TLR4 ELISA Kits) dependent.
These data suggest that Tim-3 and IFN-gamma (show IFNG ELISA Kits) may play a regulatory role in T. gondii-infected pregnant mouse model.
Gal-9 (show LGALS9 ELISA Kits), a natural TIM-3 ligand, was produced primarily by and released from ischemia-reperfusion-stressed hepatocytes, both in vivo and in vitro.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
hepatitis A virus cellular receptor 2
, T cell immunoglobulin mucin 3
, T cell immunoglobulin mucin-3
, T-cell immunoglobulin and mucin domain-containing protein 3
, T-cell membrane protein 3
, kidney injury molecule-3
, T-cell immunoglobulin and mucin domain containing 3
, hepatitis A virus cellular receptor 2 homolog