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Integrin-Binding Sialoprotein Proteins (IBSP)

The protein encoded by IBSP is a major structural protein of the bone matrix. Additionally we are shipping Integrin-Binding Sialoprotein Antibodies (84) and Integrin-Binding Sialoprotein Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IBSP 25373 P24090
IBSP 15891 Q61711
IBSP 3381 P21815
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Top Integrin-Binding Sialoprotein Proteins at

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Mammalian Cells Mouse His tag   10 μg Log in to see 5 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

IBSP Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine) ,


More Proteins for Integrin-Binding Sialoprotein (IBSP) Interaction Partners

Mouse (Murine) Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. OPN (show SPP1 Proteins) induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Proteins). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK (show BIK Proteins).

  2. Endogenous osteopontin (show SPP1 Proteins) plays a critical role in the prevention of phosphate-induced nephrocalcinosis and vascular calcification in response to high phosphate load.

  3. GATA4 (show GATA4 Proteins) acts as a negative regulator of Bsp (show KLK6 Proteins) expression in osteoblasts.

  4. Genetic deletion of osteopontin (show SPP1 Proteins) in TRAMP (show DPT Proteins) mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.

  5. IFN-gamma (show IFNG Proteins) regulates hypertensive vascular collagen remodeling induced by ANG II (show AGT Proteins) and inhibits the differentiation of Th17 cells by suppressing OPN (show SPP1 Proteins) expression and regulating secretion of inflammatory cytokines.

  6. results indicate that autocrine OPN (show SPP1 Proteins) plays a crucial role in HPC expansion, migration, and subsequent oncogenic transformation of HPCs, which may provide a new insight into hepatocarcinogenesis

  7. OPN (show SPP1 Proteins) produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke

  8. During the priming phase of liver regeneration, osteopontin (show SPP1 Proteins) enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Proteins) release and the downstream activation of Stat3 (show STAT3 Proteins).

  9. OPN (show SPP1 Proteins) deficiency accelerated the spontaneous development of colitis in mice with disrupted gut (show GUSB Proteins) microbiota and macrophage phagocytic activity.

  10. mechanical stretch (MS) directly increased OPN (show SPP1 Proteins) protein expression and secretion in vascular smooth muscle cells.

Human Integrin-Binding Sialoprotein (IBSP) interaction partners

  1. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (show RUNX2 Proteins)-Osterix (show SP7 Proteins)-BSP (show KLK6 Proteins) Signaling.

  2. Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD (show BEST1 Proteins) and postmenopausal osteoporosis by the two-stage strategy, and rs17013181 was also significantly associated with serum IBSP levels.

  3. Our results suggest that SSEA (show MPST Proteins)-4 is a specific cell surface antigen (show CD53 Proteins) that can be used to identify dental pulp stem cells.

  4. the strong correlation between bone sialoprotein (show CRISP1 Proteins) and OPN (show SPP1 Proteins) and papillary thyroid carcinoma suggests a role for BSP (show KLK6 Proteins) and OPN (show SPP1 Proteins) in calcification and tumor progression of papillary thyroid carcinoma

  5. oxidized low-density lipoprotein-induced expression dependent on Runx2 (show RUNX2 Proteins) expression

  6. Bone sialoprotein (show CRISP1 Proteins) could be a key mediator of the hypertrophic chondrocytes-induced angiogenesis of osteoarthritis.

  7. Current evidence demonstrates that BSP (show KLK6 Proteins) and OPN (show SPP1 Proteins), play significant roles in bone metastasis of osteotropic malignancies derived from breast, prostate, lung, thyroid, and multiple myeloma. [review]

  8. High expression of bone sialoprotein (show CRISP1 Proteins) in breast neoplasms was associated with cytokeratin (show KRT4 Proteins)-positive cells in bone marrow, but not with lymph node metastasis.

  9. results indicate that FGF2 (show FGF2 Proteins) increases BSP (show KLK6 Proteins) transcription by targeting the FRE (show FRZB Proteins) and AP1 (show FOSB Proteins) elements in the proximal promoter of the human BSP (show KLK6 Proteins) gene.

  10. BSP (show KLK6 Proteins) silencing decreased the integrin alphavbeta3 (show ITGAV Proteins) and beta3 levels, in turn inhibiting cell migration and invasion and decreasing the ability of the cells to metastasize to bone.

Integrin-Binding Sialoprotein (IBSP) Protein Profile

Protein Summary

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.

Gene names and symbols associated with IBSP

  • integrin-binding sialoprotein (IBSP)
  • integrin-binding sialoprotein (ibsp)
  • integrin-binding sialoprotein (LOC100344425)
  • alpha-2-HS-glycoprotein (Ahsg)
  • integrin binding sialoprotein (Ibsp)
  • integrin-binding sialoprotein (Ibsp)
  • secreted phosphoprotein 1 (Spp1)
  • 2AR protein
  • Aa2-066 protein
  • Apl-1 protein
  • BNSP protein
  • Bsp protein
  • BSP-II protein
  • Bsp2 protein
  • BSPI protein
  • BSP II protein
  • BSPII protein
  • Eta protein
  • ETA-1 protein
  • IBSP protein
  • OP protein
  • Opn protein
  • Opnl protein
  • pp63 protein
  • Ric protein
  • SP-II protein
  • Spp-1 protein

Protein level used designations for IBSP

integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) , integrin-binding sialoprotein , 59 kDa bone sialic acid-containing protein , BSP , alpha 2 HS-glycoprotein alpha 2 (fetuin) , fetuin-A , glycoprotein PP63 , phosphorylated N-glycoprotein pp63 , bone sialoprotein 2 , bone sialoprotein II , cell-binding sialoprotein , BSP II , integrin binding sialoprotein , Bone sialoprotein 2 , 44 kDa bone phosphoprotein , bone sialoprotein 1 , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin , osteopontin-like protein

471249 Pan troglodytes
609146 Canis lupus familiaris
701835 Macaca mulatta
100192352 Xenopus laevis
100271750 Xenopus (Silurana) tropicalis
100344425 Oryctolagus cuniculus
25373 Rattus norvegicus
15891 Mus musculus
3381 Homo sapiens
24477 Rattus norvegicus
281233 Bos taurus
396071 Gallus gallus
397137 Sus scrofa
20750 Mus musculus
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