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Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Additionally we are shipping and many more products for this protein.
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Mouse (Murine) Polyclonal Ifi202b Primary Antibody for WB - ABIN4222423
Panchanathan, Liu, Liu, Fang, Erickson, Pitha, Choubey: Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 3 references for ABIN4222423
These results, together with the reported data on p202 HINb, lead to an interaction model for full-length p202 and dsDNA which provides a conceivable mechanism for the negative regulation of Aim2 (show AIM2 Antibodies) inflammasome activation by p202.
p202 plays a role in mouse adipose-derived stem cell adipogenesis.
Authors hypothesize that while p202 was evolutionarily selected to limit AIM2 (show AIM2 Antibodies)-mediated inflammation in some mouse strains, the same mechanism contributes to increased interferon (show IFNA Antibodies) production and lupus susceptibility.
Ifi202b modulates fat accumulation through expression of adipogenic genes such as 11beta-Hsd1 (show HSD11B1 Antibodies).
Studies identify p202 as a regulator of murine BAFF (show TNFSF13B Antibodies).
Our observations demonstrate that cell type and gender-dependent factors differentially regulate the expression of the Aim2 (show AIM2 Antibodies) and p202 proteins
Our findings indicate a potential role for Ifi202b in the suppressive capacity of peptide-induced regulatory CD8 (show CD8A Antibodies)(+) Ti cells.
expression of Aim2 (show AIM2 Antibodies) protein is required to maintain the expression of the Fcgr2b (show FCGR2B Antibodies) gene and also predict epistatic interactions between the Ifi200 genes and the Fcgr2b (show FCGR2B Antibodies) gene within the Nba2 interval
Findings delineate a new role of the IFN-gamma (show IFNG Antibodies) signaling pathway in regulating T cell proliferation and apoptosis through upregulating survivin (show BIRC5 Antibodies) and ifi202 expression.
Aim2 (show AIM2 Antibodies) deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53.
Interferon-activatable protein 202a (Ifi-202a) (Interferon-inducible protein p202a)
, interferon activated gene 202A
, interferon-activable protein 202
, interferon-inducible protein p202
, lupus susceptibility protein p202