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IDE Antibodies

(Insulin-Degrading Enzyme (IDE))
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
IDE antibody  (AA 491-590) IDE antibody  (AA 491-590) IDE antibody (AA 491-590) (ABIN723680)

IDE Reactivity: Human, Mouse, Rat ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB Host: Rabbit Polyclonal unconjugated

IDE antibody (AA 491-590) (ABIN723665)

IDE Reactivity: Mouse ELISA, IHC (fro), IHC (p), WB Host: Mouse Polyclonal unconjugated

IDE antibody  (AA 1-250) IDE antibody  (AA 1-250) IDE antibody (AA 1-250) (ABIN3022285)

IDE Reactivity: Human IF, WB Host: Rabbit Polyclonal unconjugated

IDE Antibodies by Grade

Find IDE Antibodies with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

IDE Antibodies by Reactivity

Find IDE Antibodies for a variety of species such as anti-Human IDE, anti-Mouse IDE, anti-Rat IDE. The species listed below are among those available. Click on a link to go to the corresponding products.

IDE Antibodies by Application

Find IDE Antibodies validated for a specific application such as WB, ELISA, IHC, IF (cc). Some of the available applications are listed below. Click on a link to go to the corresponding products.

IDE Antibodies by Host

Find IDE Antibodies with a specific Host. The Host listed below are among those available. Click on a link to go to the corresponding products.

IDE Antibodies by Binding Specificity

Find IDE Antibodies with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

IDE Antibodies by Clonality

Find available monoclonal or polyclonal IDE Antibodies. Click on a link to go to the corresponding products.

IDE Antibodies by Clone

Find IDE Antibodies with a specific Clone. The Clone listed below are among those available. Click on a link to go to the corresponding products.

IDE Antibodies by Conjugate

Find IDE Antibodies with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular IDE Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (6)
  • (2)
Cat. No. ABIN723680
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application ELISA, IHC (fro), IHC (p), WB
Validations
  • (1)
Cat. No. ABIN723665
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, WB
Validations
  • (5)
Cat. No. ABIN3022285
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, FACS, IHC (p), WB
Validations
  • (4)
Cat. No. ABIN5708390
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN6262443
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (3)
Cat. No. ABIN334425
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IF, IHC (p), WB
Validations
  • (3)
Cat. No. ABIN7250134
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (3)
Cat. No. ABIN5693119
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IC, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7307896
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN561416
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC (p), WB
Validations
  • (3)
Cat. No. ABIN5534405
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (2)
Cat. No. ABIN7156344
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN3181153
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application EIA, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN356957
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, WB
Validations
  • (1)
Cat. No. ABIN7000194
Quantity 20 μL
Datasheet Datasheet

Latest Publications for our IDE Antibodies

Radulescu, Fischer, Stange, Schulze: "Promoting scientific standards in Germany." in: Science (New York, N.Y.), Vol. 328, Issue 5976, pp. 307, (2010) (PubMed).

Radulescu, Poznic, Pavelic: "Complex formation between metabolic enzymes in tumor cells: unfolding the MDR1-IDE paradigm." in: Molecular cancer therapeutics, Vol. 8, Issue 11, pp. 3171, (2009) (PubMed).

Kim, Hersh, Leissring, Ingelsson, Matsui, Farris, Lu, Hyman, Selkoe, Bertram, Tanzi: "Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7825-32, (2007) (PubMed).

Zhao, Xiang, Haroutunian, Buxbaum, Stetka, Pasinetti: "Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease." in: Neurobiology of aging, Vol. 28, Issue 6, pp. 824-30, (2007) (PubMed).

Vepsäläinen, Parkinson, Helisalmi, Mannermaa, Soininen, Tanzi, Bertram, Hiltunen: "Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population." in: Journal of medical genetics, Vol. 44, Issue 9, pp. 606-8, (2007) (PubMed).

Radulescu, Hufnagel, Luppa, Hellebrand, Kuo, Rosner, Harbeck, Giersig, Meindl, Schmitt, Weirich: "Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels." in: International journal of oncology, Vol. 30, Issue 1, pp. 73-80, (2006) (PubMed).

Aliases for IDE Antibodies

insulin degrading enzyme (IDE) Antibodies
insulin-degrading enzyme (ide) Antibodies
insulin-degrading enzyme (LOC591315) Antibodies
insulin-degrading enzyme (CC1G_01115) Antibodies
insulin-degrading enzyme (Bm1_26615) Antibodies
insulin-degrading enzyme (PTRG_10875) Antibodies
metallopeptidase (SJAG_01430) Antibodies
insulin-degrading enzyme (EBI_21700) Antibodies
insulin-degrading enzyme (VDBG_06702) Antibodies
insulin-degrading enzyme (LOAG_08082) Antibodies
insulin-degrading enzyme (PGTG_04982) Antibodies
insulin-degrading enzyme (Tsp_00424) Antibodies
insulin degrading enzyme (Ide) Antibodies
1300012G03Rik Antibodies
4833415K22Rik Antibodies
AA675336 Antibodies
AI507533 Antibodies
IDE Antibodies
INSDEGM Antibodies
INSULYSIN Antibodies
zgc:162603 Antibodies
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