Interleukin 1 Receptor-Like 1 Proteins (IL1RL1)

The protein encoded by IL1RL1 is a member of the interleukin 1 receptor family. Additionally we are shipping IL1RL1 Antibodies (124) and IL1RL1 Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IL1RL1 17082 P14719
IL1RL1 9173 Q01638
Rat IL1RL1 IL1RL1 25556 Q62611
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Top IL1RL1 Proteins at

Showing 10 out of 25 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
HOST_HEK-293 Cells Human Fc Tag Human IL-1RL1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%. Immobilized Human IL-33, Tag Free  with a linear range of 1.95-7.8 ng/mL. 200 μg Log in to see 21 to 31 Days
HOST_Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
HOST_Human Cells Human Un-conjugated 100 μg Log in to see 20 to 21 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_HEK-293 Human Un-conjugated   25 μg Log in to see 10 to 12 Days
HOST_CHO Cells Human DYKDDDDK Tag Validation with Western Blot 50 μg Log in to see 6 to 10 Days

IL1RL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
, ,
Human , , , , , ,
, , , ,

Top referenced IL1RL1 Proteins

  1. Human IL1RL1 Protein expressed in HEK-293 - ABIN2666553 : Demyanets, Kaun, Pentz, Krychtiuk, Rauscher, Pfaffenberger, Zuckermann, Aliabadi, Gröger, Maurer, Huber, Wojta: Components of the interleukin-33/ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature. in Journal of molecular and cellular cardiology 2013 (PubMed)
    Show all 5 references for 2666553

  2. Human IL1RL1 Protein expressed in Human Cells - ABIN2002071 : Schmitz, Owyang, Oldham, Song, Murphy, McClanahan, Zurawski, Moshrefi, Qin, Li, Gorman, Bazan, Kastelein: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. in Immunity 2005 (PubMed)
    Show all 5 references for 2002071

  3. Human IL1RL1 Protein expressed in Human Cells - ABIN2002075 : Trajkovic, Sweet, Xu: T1/ST2--an IL-1 receptor-like modulator of immune responses. in Cytokine & growth factor reviews 2004 (PubMed)
    Show all 5 references for 2002075

  4. Mouse (Murine) IL1RL1 Protein expressed in Human Cells - ABIN2008684 : Hayakawa, Hayakawa, Kume, Tominaga: Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. in The Journal of biological chemistry 2007 (PubMed)
    Show all 5 references for 2008684

  5. Human IL1RL1 Protein expressed in HEK-293 Cells - ABIN2181368 : Tago, Noda, Hayakawa, Iwahana, Yanagisawa, Yashiro, Tominaga: Tissue distribution and subcellular localization of a variant form of the human ST2 gene product, ST2V. in Biochemical and biophysical research communications 2001 (PubMed)
    Show all 2 references for 2181368

More Proteins for Interleukin 1 Receptor-Like 1 (IL1RL1) Interaction Partners

Mouse (Murine) Interleukin 1 Receptor-Like 1 (IL1RL1) interaction partners

  1. these studies establish a basal defect in eosinophilopoiesis in IL-33 (show IL33 Proteins)- and ST2 (show SULT2A1 Proteins)-deficient mice and a mechanism whereby IL-33 (show IL33 Proteins) supports eosinophils by driving both systemic IL-5 (show IL5 Proteins) production and the expansion of IL-5Ralpha-expressing precursor cells

  2. These results shed light on endogenous IL-33/ST2 signaling as a potential immune regulatory mechanism that serves to promote beneficial microglial responses and mitigate ischemic brain injury after stroke.

  3. Plasmodium berghei infection triggered a dramatic increase of IL-33 expression by oligodendrocytes, through ST2 pathway.

  4. Data, including data from studies using knockout mice, suggest that signal transduction via IL33 (show IL33 Proteins)/ST2L (show TMED1 Proteins) (interleukin 33/interleukin-33 (show IL33 Proteins) receptor) plays a cardioprotective role in myocardial remodeling under mechanical stress (which leads to left ventricular hypertrophy and heart failure).

  5. IL-33 acts as a potent immune modulator protecting the liver through activation of ST2(+) Treg cells and control of natural killer cells in immune cell-mediated hepatitis.

  6. These studies clearly show a crucial role for IL-4 in the induction of airway hyperresponsiveness following Strongyloides venezuelensis infection and for IL-33/ST2 in maintaining airway hyperresponsiveness and lung Th2 responses.

  7. IL-33/ST2 pathway plays a role in enhancing inflammation and tissue damage at the site of acute inflammation.

  8. the present study hypothesized that IL-33, as a 'master switch' of tissue repair that is secreted from dying or apoptotic cells, activated the IL-33-ST2-MyD88-TRAF6 pathway, amplified Th2-type responses and was involved in the pulmonary fibrosis process, via its receptor ST2, a stable marker of Th2 cells.

  9. ST2 deletion increases inflammatory bone loss in experimental periapical lesions in mice.

  10. ST2 receptor invalidation maintains wound inflammation, delays healing and increases fibrosis

Human Interleukin 1 Receptor-Like 1 (IL1RL1) interaction partners

  1. In a cohort of hypertensive heart failure subjects, soluble ST2 correlates significantly with indicators of right ventricular function.

  2. Data provide evidence that increased IL-33/ST2 levels in patients with chronic kidney disease are an indicator of increased inflammation, impaired endothelial functions, and cardiovascular events.

  3. Serum levels of IL33R were positively correlated with cognitive performance in patients with schizophrenia.

  4. Interleukin 1 receptor-like 1 (ST2/IL1RL1) is a biomarker for cardiac stress and heart failure, which can be associated with cocaine use. Data suggest that serum ST2/IL1RL1 levels are up-regulated by cocaine use; cocaine use appears to be associated with subclinical cardiac stress and damage outside of acute cardiac events; elevated serum ST2/IL1RL1 levels may serve as biomarkers for cocaine-induced cardiac complications.

  5. Preterm labor was associated with diminished expression of the alpha-chain (show FCGRT Proteins) of IL-33 (show IL33 Proteins) receptor on choriodecidual B cells.

  6. Study found that macrophages expressed ST2L with a membrane pattern. The membrane pattern of ST2L was strongly expressed if the macrophages infiltrating the shoulder region of the plaque had an epithelioid aspect suggesting its possible role in the pathogenetic mechanisms of atherosclerotic lesions progression and rupture.

  7. The higher levels of IL-33 and its receptor ST2 in tissue and serum reflect an active inflammatory state and may represent a potential biomarker for disease activity.

  8. The genetic risk score for rs1041973 and rs16924161 demonstrated a higher risk for SPT (show AGXT Proteins) positivity against B. tropicalis, the greater the number of risk alleles for both SNPs. Our findings demonstrate a robust association of genetic variants in IL1RL1 and IL33 (show IL33 Proteins) SNPs with allergy markers and asthma.

  9. Increased sST2 (show SSTR2 Proteins) and IL-10 (show IL10 Proteins) but not IL-33 (show IL33 Proteins) may be involved in the pathogenic process of IgAN.

  10. No significant differences in genotypic and allelic frequencies of thers13015714 in interleukin 1 receptor like 1 was observed between cases and controls and between mild/severe and early/late-onset Preeclampsia.

IL1RL1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with IL1RL1

  • interleukin 1 receptor-like 1 (Il1rl1)
  • interleukin 1 receptor-like 1 (IL1RL1)
  • DER4 protein
  • FIT-1 protein
  • FIT1 protein
  • IL33R protein
  • Ly84 protein
  • ST2 protein
  • St2-rs1 protein
  • ST2L protein
  • ST2V protein
  • T1 protein
  • T1/ST2 protein

Protein level used designations for IL1RL1

T1 , interleukin-1 receptor-like 1 , lymphocyte antigen 84 , protein T1 , growth stimulation-expressed , homolog of mouse growth stimulation-expressed , interleukin 1 receptor-related protein , fos-responsive gene 1 protein

17082 Mus musculus
9173 Homo sapiens
611442 Canis lupus familiaris
374136 Gallus gallus
25556 Rattus norvegicus
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