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Interleukin 28B (Interferon, lambda 3) Proteins (IL28B)

IL28B encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping Interleukin 28B (Interferon, lambda 3) Antibodies (99) and Interleukin 28B (Interferon, lambda 3) Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat IL28B IL28B 685840  
IL28B 338374 Q8CGK6
IL28B 282617 Q8IZI9
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Top Interleukin 28B (Interferon, lambda 3) Proteins at

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_HEK-293 Human Un-conjugated 50 μg Log in to see 2 to 3 Days
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
HOST_Mammalian Cells Human His tag   50 μg Log in to see 5 Days
HOST_Human Human His tag   10 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 to 13 Days
Yeast Human His tag   100 μg Log in to see 16 Days

IL28B Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , , ,

Top referenced Interleukin 28B (Interferon, lambda 3) Proteins

  1. Human IL28B Protein expressed in Human Cells - ABIN2004870 : Sheppard, Kindsvogel, Xu, Henderson, Schlutsmeyer, Whitmore, Kuestner, Garrigues, Birks, Roraback, Ostrander, Dong, Shin, Presnell, Fox, Haldeman, Cooper, Taft, Gilbert, Grant, Tackett, Krivan et al.: IL-28, IL-29 and their class II cytokine receptor IL-28R. ... in Nature immunology 2002 (PubMed)
    Show all 4 references for ABIN2004870

More Proteins for Interleukin 28B (Interferon, lambda 3) (IL28B) Interaction Partners

Mouse (Murine) Interleukin 28B (Interferon, lambda 3) (IL28B) interaction partners

  1. IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX (show HSP Proteins) vaccination but does not improve the protective immune responses.

  2. the role of IFN-lambda in IDO (show IDO1 Proteins) regulation was investigated after influenza infection of respiratory epithelial cells.

  3. Data indicate that rotavirus infection induces production of interferon (show IFNA Proteins)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 Proteins)) by intestinal epithelial cells.

  4. Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c (show ITGAX Proteins)(+) DC function in experimental allergic asthma.

  5. IFN-alpha (show IFNA Proteins), IFN-beta (show IFNB1 Proteins), and IFN-gamma (show IFNG Proteins) were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta (show IFNB1 Proteins) and IFN-gamma (show IFNG Proteins) were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection

  6. the duration of IFNlambda signaling to JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) is different from that of IFNalpha

  7. intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR (show IFNAR1 Proteins)-/- mice

  8. IL-28A (show IL28A Proteins) emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury

  9. Type III interferon (show IFNA Proteins)/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll (show TLR4 Proteins)-like receptors, largely mediated by inducing an antiviral state in epithelial cells.

  10. IL-28B can induce 100% protection from mortality after a lethal influenza challenge

Human Interleukin 28B (Interferon, lambda 3) (IL28B) interaction partners

  1. The IL13 (show IL13 Proteins) rs20541 T allele and IL28B rs8099917 GG genotype are negative predictors of survival in patients on renal replacement therapy, while the IL28B rs12979860 TT genotype increases the risk of death only in patients negative for HBV or HCV infection.

  2. In this study, there was association of the three isolated polymorphisms (rs8099917, rs12979860 and rs368234815) with both clinical outcome and response to treatment with PEG (show PAEP Proteins)-IFN and RBV in chronic hepatitis C.

  3. The frequency of colonic Treg cells in hepatitis C virus-infected patients had a strong association with the IL-28B genotype and may have a significant impact on hepatitis C virus clearance.

  4. In treatment-naive chronic hepatitis C patients treated with pegylated interferon (show IFNA Proteins) and ribavirin, a polymorphism upstream CC at the site rs12979860 of IL-28B is associated with increased sustained virologic response and effectively predicts treatment outcome.

  5. findings support a model in which IFNL3 mRNA translation efficiency, governed by allele-specific mRNA structures, modulates clearance of hepatitis C virus infection

  6. SNP rs4803217, located in the 3' untranslated region (UTR) of IFNL3, has also been proposed as a causal variant for HCV clearance

  7. IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytes

  8. study conducted to determine the association of IL-28B rs12980275, rs12979860, and rs8099917 gene polymorphism(s) with the response (including relapse) following dual pegIFN and ribavirin therapy in genotype 4 hepatitis C Egyptian patients; SNPs at IL-28/60 and IL-28/75 are possible predictors of relapse in patients receiving dual treatment

  9. Steatosis severity was independently associated with IL28B rs12979860 in large cohort of patients with genotype 1 Chronic hepatitis C.

  10. Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure sustained viral response in naive CHC G4 patients treated with low cost standard therapy.

Interleukin 28B (Interferon, lambda 3) (IL28B) Protein Profile

Protein Summary

This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).

Gene names and symbols associated with IL28B

  • interferon, lambda 3 (Ifnl3)
  • interleukin 29 (interferon, lambda 1) (IL29)
  • interferon lambda 3 (Ifnl3)
  • interferon, lambda 3 (IFNL3)
  • IFL-1 protein
  • IL-28B protein
  • Il28 protein
  • IL28B protein
  • IL28C protein
  • INF-alpha protein
  • INF-lambda protein

Protein level used designations for IL28B

interleukin 28B , interleukin-29 , IFN-lambda-3 , interferon alpha , interferon lambda-3 , interleukin 28 , interleukin-28B , IFN-lambda-4 , IL-28C , cytokine Zcyto22 , interferon lambda-4 , interferon, lambda 4 , interleukin 28B (interferon, lambda 3) , interleukin 28C , interleukin-28C

685840 Rattus norvegicus
100620067 Bos taurus
338374 Mus musculus
282617 Homo sapiens
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