IL28B Protein (His tag)
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- Target See all IL28B Proteins
- IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Human Cells
- Purification tag / Conjugate
- This IL28B protein is labelled with His tag.
- Purpose
- Recombinant Human IFN-λ3/IL-28B Protein (Human Cells, His Tag)(Active)
- Sequence
- Val22-Val196
- Characteristics
- Recombinant Human Interleukin-28B is produced by our Mammalian expression system and the target gene encoding Val22-Val196 is expressed with a 6His tag at the C-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Human IL-28-His at 10μg/ml(100 μl/well) can bind Human IL-10RB-Fc(Cat: PKSH032564). The ED50 of Human IL-28-His is 0.37 ug/ml.
- Top Product
- Discover our top product IL28B Protein
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Interleukin 28B (Interferon, lambda 3) (IL28B) (AA 20-193) protein (His tag)
Crystallography grade IL28B Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl,1 mM EDTA, pH 7.4.
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))
- Alternative Name
- IFN-lambda3/IL-28B (IL28B Products)
- Synonyms
- Il28b Protein, IFL-1 Protein, IL-28B Protein, INF-alpha Protein, INF-lambda Protein, Il28 Protein, IL28B Protein, IL28C Protein, interferon, lambda 3 Protein, interferon lambda 3 Protein, Ifnl3 Protein, IFNL3 Protein
- Background
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Background: Interleukin-28B, also known as Cytokine Zcyto22, Interferon lambda-3, Interferon lambda-4, IFNL3, IFNL4, ZCYTO22 and IL28B, is a secreted cytokine which belongs to the IL-28/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition, IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
Synonym: Interleukin-28B, IL-28B, Cytokine Zcyto22, Interferon Lambda-3, IFN-Lambda-3, Interferon Lambda-4, IFN-Lambda-4, Interleukin-28C, IL-28C, IL28B, IFNL3, IFNL4, IL28C, ZCYTO22
- Molecular Weight
- 20.7 kDa
- UniProt
- Q8IZI9
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