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Interleukin 6 Proteins (IL6)

IL6 encodes a cytokine that functions in inflammation and the maturation of B cells. Additionally we are shipping Interleukin 6 Antibodies (909) and Interleukin 6 Kits (296) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IL6 16193 P08505
Rat IL6 IL6 24498 P20607
IL6 3569 P05231
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Top Interleukin 6 Proteins at

Showing 10 out of 213 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 9 to 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   5 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Cynomolgus Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 4 pack Log in to see 10 to 12 Days

IL6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
Rat (Rattus) , ,

Human , , , , , , , , ,
, ,

Top referenced Interleukin 6 Proteins

  1. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2667541 : Murakami, Hibi, Nakagawa, Nakagawa, Yasukawa, Yamanishi, Taga, Kishimoto: IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. in Science (New York, N.Y.) 1993 (PubMed)
    Show all 5 references for ABIN2667541

  2. Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110 : Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Show all 5 references for ABIN1305110

  3. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109 : Prussin, Metcalfe: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. in Journal of immunological methods 1996 (PubMed)
    Show all 5 references for ABIN1305109

  4. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2002764 : Kishimoto, Akira, Narazaki, Taga: Interleukin-6 family of cytokines and gp130. in Blood 1995 (PubMed)
    Show all 4 references for ABIN2002764

  5. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111 : Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991 (PubMed)
    Show all 4 references for ABIN1305111

  6. Cynomolgus Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2009972 : Heinrich, Behrmann, Müller-Newen, Schaper, Graeve: Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. in The Biochemical journal 1998 (PubMed)
    Show all 3 references for ABIN2009972

  7. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2007389 : Chung, Seo, Hur, Kim, Kim, Jung, Kim, Park, Shin: Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. in Journal of human genetics 2003 (PubMed)
    Show all 3 references for ABIN2007389

  8. Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747 : Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010 (PubMed)

  9. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195 : Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014 (PubMed)

More Proteins for Interleukin 6 (IL6) Interaction Partners

Mouse (Murine) Interleukin 6 (IL6) interaction partners

  1. Deficiency of IkBNS induces atherogenesis in LDL receptor (show LDLR Proteins)-deficient mice and increases IL-6 production.

  2. IL-6/P-STAT3 (show STAT3 Proteins) activation influences p63 (show CKAP4 Proteins) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

  3. IL6/STAT3 (show STAT3 Proteins) signalling dysregulation, caused by IL6 deficiency, resulted in skewing of the immune modulatory properties of mesenchymal stem cells to favour a pro-inflammatory profile.

  4. cocoa (show CALCOCO1 Proteins) diet suppresses colitis associated tumorigenesis, and its antitumor effect is partly mediated by limiting IL-6/STAT3 (show STAT3 Proteins) activation

  5. Results suggest a potential role for neuroadaptive effects of ethanol-induced astrocyte production of interleukin-6 as a mediator or modulator of the actions of ethanol on the central nervous system, including persistent changes in central nervous system function that contribute to cognitive dysfunction and the development of alcohol dependence.

  6. IL-6 sustains levels of hepatic lipogenic enzymes during fasting through activation of STAT3 (show STAT3 Proteins)

  7. Tumor-driven, unremitting expression of Satb1 (show SATB1 Proteins) in activated Zbtb46 (show ZNF340 Proteins)+ inflammatory dendritic cells that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by increased secretion of tumor-promoting Galectin-1 (show LGALS1 Proteins) and IL-6.

  8. the results of the present study strongly suggest that mimosine, a normoxic inducer of HIF, inhibits the PGF2ainduced osteoprotegerin (show TNFRSF11B Proteins) synthesis without affecting the IL-6 synthesis in osteoblasts

  9. IL-6 signaling in dendritic cells is essential for their uptake of allergens, maturation, and initiation of Th2/Th17-mediated airway inflammation and airway hyper-reactivity in asthma

  10. IL-6/gp130 (show LRPPRC Proteins) signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters

Human Interleukin 6 (IL6) interaction partners

  1. Meta-analysis demonstrates a significant association between childhood trauma and increased immune activation (peripheral CRP (show CRP Proteins), IL-6 andTNF-alpha) in adulthood, and highlights possible differential effects of different types of trauma as well as heterogeneity in the findings

  2. Results revealed that the distribution of the genotypes and allele frequencies of the IL-6 -174G/C polymorphism were not significantly different between the Familial Mediterranean Fever (show MEFV Proteins) patients and the healthy controls.

  3. There were no significant differences between patients with Behcet's disease and controls with respect to the IL-1Ra (show IL1RN Proteins), IL-1beta (show IL1B Proteins), IL-2 (show IL2 Proteins), IL-6 and the IL-10 (show IL10 Proteins) gene polymorphism distributions. Correlations between the articular involvement and IL-1RN (show IL1RN Proteins), the ocular involvement and the IL-1beta (show IL1B Proteins), and the age of disease onset and the IL-2 (show IL2 Proteins) and IL-10 (show IL10 Proteins) polymorphisms suggest that that they could be associated with disease symptoms.

  4. Allele A of rs2069843 and allele T of rs2069849 of IL-6were suggestively associated with the loss of MIs (show AMH Proteins) for orthodontic anchorage and were in complete linkage disequilibrium.

  5. TNF-alpha (show TNF Proteins) and IL-6 were found to be upregulated in IPA tissue compared with that of NIPA (show ZC3HC1 Proteins) (P < 0.05). These proteins may therefore play important roles in the occurrence and progression of IPA.

  6. The results of this study suggested that IL-6 (G174C) polymorphism is significantly associated with the risk of IS in North Indian population.

  7. Study showed that patients with schizophrenia had: (1) a significant increase in serum VEGF (show VEGFA Proteins) protein levels; (2) reduced volumes in both the superior frontal gyrus and the frontal pole; (3) a significant inverse relationship between serum VEGF (show VEGFA Proteins) and total frontal pole volume; and (4) a significant positive association between serum VEGF (show VEGFA Proteins) and IL-6 mRNA levels

  8. Study analyzed early neurobiological markers involved in inflammatory activation in newborns with a history of crack/cocaine exposure in utero and found a significant increase in inflammatory activation in newborns with a history of intrauterine crack/cocaine exposure, as assessed both by IL-6 and IL-10 (show IL10 Proteins) measures

  9. the expression pattern of IL-6 detected by immunohistochemistry is helpful to distinguish Castleman disease subtypes and reactive mimics.

  10. Donor IL6 rs2069852 polymorphisms may be a potential genetic marker for Hepatocellular Carcinoma recurrence after liver transplantation in the Han Chinese population.

Cow (Bovine) Interleukin 6 (IL6) interaction partners

  1. when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.

  2. The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.

  3. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  4. Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.

  5. The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6, IL-12 (show IL12A Proteins)]

  6. results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes.

  7. Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.

Rabbit Interleukin 6 (IL6) interaction partners

  1. Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Proteins) and IL-6 in rabbit cornea cells.

Pig (Porcine) Interleukin 6 (IL6) interaction partners

  1. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10 (show IL10 Proteins), and IL-6 in ovarian follicles are reported.

  2. Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Proteins) (signal transducer/activator of transcription (show STAT1 Proteins) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Proteins) expression/phosphorylation).

  3. LIF (show LIF Proteins) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.

  4. INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.

  5. interleukin-6, endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury

  6. Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6, quickly and reliably signaled adverse interactions.

  7. IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.

  8. These results suggest that TNF-alpha (show TNF Proteins) and IL-10 (show IL10 Proteins), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.

  9. These results suggest that IL-6 mRNA expression in porcine immune cells is cell-type specific and the results of this study could be used as the basis for research on the porcine immune system.

  10. role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance

Goat Interleukin 6 (IL6) interaction partners

  1. Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.

Horse (Equine) Interleukin 6 (IL6) interaction partners

  1. These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.

  2. IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Proteins) signaling pathway transactivator beta-catenin (show CTNNB1 Proteins), induced expression of inhibitors of the Wnt (show WNT2 Proteins) pathway, and increased expression of GDF-5 (show GDF5 Proteins).

  3. study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Proteins) activation and that this effect can be modulated by A2AAR (show ADORA2A Proteins)

  4. Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.

  5. Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.

  6. Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Proteins) alone, were useful diagnostic indices of sepsis in equine neonates.

  7. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Proteins) and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rainbow Trout (Oncorhynchus mykiss) Interleukin 6 (IL6) interaction partners

  1. IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.

  2. in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout

  3. found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Proteins)), are potent inducers of IL-1beta (show IL1B Proteins) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Proteins).

Interleukin 6 (IL6) Protein Profile

Protein Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

Gene names and symbols associated with Interleukin 6 Proteins (IL6)

  • interleukin 6 (Il6)
  • interleukin 6 (interferon, beta 2) (IL6)
  • interleukin-6 (il-6)
  • BSF2 protein
  • CHIL-6 protein
  • HGF protein
  • HSF protein
  • IFNB2 protein
  • IL-6 protein
  • il6 protein
  • ILg6 protein

Protein level used designations for Interleukin 6 Proteins (IL6)

B-cell hybridoma growth factor , interleukin HP-1 , interleukin-6 , IL-6 , Interleukin 6 (interferon, beta 2) , B-cell differentiation factor , B-cell stimulatory factor 2 , BSF-2 , CDF , CTL differentiation factor , IFN-beta-2 , hybridoma growth factor , interferon beta-2 , interleukin BSF-2 , Anpl-IL*06-01 , interleukin-6 protein , interferon-beta-2

16193 Mus musculus
24498 Rattus norvegicus
3569 Homo sapiens
443406 Ovis aries
395337 Gallus gallus
280826 Bos taurus
403985 Canis lupus familiaris
101798321 Anas platyrhynchos
100008733 Oryctolagus cuniculus
399500 Sus scrofa
517016 Bos taurus
100860785 Capra hircus
100034196 Equus caballus
493687 Felis catus
705819 Macaca mulatta
101281783 Orcinus orca
100136689 Oncorhynchus mykiss
503562 Takifugu rubripes
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