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Interleukin 6 Proteins (IL6)

IL6 encodes a cytokine that functions in inflammation and the maturation of B cells. Additionally we are shipping Interleukin 6 Antibodies (894) and Interleukin 6 Kits (285) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IL6 16193 P08505
Rat IL6 IL6 24498 P20607
IL6 3569 P05231
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Top Interleukin 6 Proteins at

Showing 10 out of 216 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 9 to 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   5 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   5 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   50 μg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Cynomolgus Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 4 pack Log in to see 10 to 12 Days

IL6 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
Rat (Rattus) , ,

Human , , , , , , , , ,
, ,

Top referenced Interleukin 6 Proteins

  1. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2667541 : Murakami, Hibi, Nakagawa, Nakagawa, Yasukawa, Yamanishi, Taga, Kishimoto: IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. in Science (New York, N.Y.) 1993 (PubMed)
    Show all 5 references for ABIN2667541

  2. Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305110 : Chiu, Moulds, Coffman, Rennick, Lee: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells. in Proceedings of the National Academy of Sciences of the United States of America 1988 (PubMed)
    Show all 5 references for ABIN1305110

  3. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305109 : Prussin, Metcalfe: Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. in Journal of immunological methods 1996 (PubMed)
    Show all 5 references for ABIN1305109

  4. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2002764 : Kishimoto, Akira, Narazaki, Taga: Interleukin-6 family of cytokines and gp130. in Blood 1995 (PubMed)
    Show all 4 references for ABIN2002764

  5. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1305111 : Kitamura, Takaku, Miyajima: IL-1 up-regulates the expression of cytokine receptors on a factor-dependent human hemopoietic cell line, TF-1. in International immunology 1991 (PubMed)
    Show all 4 references for ABIN1305111

  6. Mouse (Murine) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2007389 : Heinrich, Behrmann, Müller-Newen, Schaper, Graeve: Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. in The Biochemical journal 1998 (PubMed)
    Show all 3 references for ABIN2007389

  7. Cynomolgus Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN2009972 : Chung, Seo, Hur, Kim, Kim, Jung, Kim, Park, Shin: Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. in Journal of human genetics 2003 (PubMed)
    Show all 3 references for ABIN2009972

  8. Rat (Rattus) Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1525747 : Andrianjafiniony, Dupré-Aucouturier, Letexier, Couchoux, Desplanches: Oxidative stress, apoptosis, and proteolysis in skeletal muscle repair after unloading. in American journal of physiology. Cell physiology 2010 (PubMed)

  9. Human Interleukin 6 Protein expressed in Escherichia coli (E. coli) - ABIN1878195 : Fan, Ren, Zhu, Zhang, Zhu: A new signal amplification strategy of photoelectrochemical immunoassay for highly sensitive interleukin-6 detection based on TiO2/CdS/CdSe dual co-sensitized structure. in Biosensors & bioelectronics 2014 (PubMed)

More Proteins for Interleukin 6 (IL6) Interaction Partners

Mouse (Murine) Interleukin 6 (IL6) interaction partners

  1. Study indicated that SOCS3 (show SOCS3 Proteins) suppresses complete polarization to M1 phenotype through blocking IL6 production, and Abeta (show APP Proteins)-challenged primary-cultured microglia replicate the in vivo gene expression pattern of microglia in APPswe/PS1dE9 mice

  2. GABA-B receptor antagonists reduced Il6 levels in male mice and increased Il6 levels in female mice following neonatal hypoxia ischemia.

  3. Lipopolysaccharides significantly up-regulated RANKL (show TNFSF11 Proteins) expression and activated the ERK1/2 pathway to induce IL-6 mRNA expression and protein synthesis in MLO-Y4 cells.

  4. Data show that regulation of interleukin-6 (IL-6) on transforming growth factor beta1 (TGFbeta1 (show TGFB1 Proteins)) and microRNA miR (show MLXIP Proteins)-29 pathway reduced myocardial fibrosis and improved cardiac function of diabetic mice.

  5. Deficiency of IkBNS induces atherogenesis in LDL receptor (show LDLR Proteins)-deficient mice and increases IL-6 production.

  6. IL-6/P-STAT3 (show STAT3 Proteins) activation influences p63 (show CKAP4 Proteins) isoform expression in healing wounds, which may contribute to wound-induced hair follicle neogenesis.

  7. IL6/STAT3 (show STAT3 Proteins) signalling dysregulation, caused by IL6 deficiency, resulted in skewing of the immune modulatory properties of mesenchymal stem cells to favour a pro-inflammatory profile.

  8. cocoa (show CALCOCO1 Proteins) diet suppresses colitis associated tumorigenesis, and its antitumor effect is partly mediated by limiting IL-6/STAT3 (show STAT3 Proteins) activation

  9. Results suggest a potential role for neuroadaptive effects of ethanol-induced astrocyte production of interleukin-6 as a mediator or modulator of the actions of ethanol on the central nervous system, including persistent changes in central nervous system function that contribute to cognitive dysfunction and the development of alcohol dependence.

  10. IL-6 sustains levels of hepatic lipogenic enzymes during fasting through activation of STAT3 (show STAT3 Proteins)

Human Interleukin 6 (IL6) interaction partners

  1. Study demonstrated for the first time that depressive symptoms in COPD (show ARCN1 Proteins) patients may be related to inflammatory state as confirmed with increased levels of IL-6 both in COPD (show ARCN1 Proteins) and depression and also in COPD (show ARCN1 Proteins) with comorbid depressive symptoms.

  2. HIC1 (show HIC1 Proteins) attenuates invasion and metastasis by inhibiting the IL-6/STAT3 (show STAT3 Proteins) signalling pathway in human pancreatic ductal adenocarcinoma.

  3. study provided the first evidence that B7-H4 (show VTCN1 Proteins) facilitated esophageal squamous cell carcinoma cell proliferation through promoting IL-6/STAT3 (show STAT3 Proteins) positive loopback pathway activation

  4. SCCAg, CYFRA 21.1, IL-6, VEGF and sTNF receptors have roles in squamous cell cervical cancer

  5. The results of western blotting revealed that the protein expression levels of FH and FHL1 (show FHL1 Proteins) were not regulated by IL6 and IL8 (show IL8 Proteins) in a dosedependent manner. Immunofluorescence analysis confirmed that the A2780 ovarian cancer cell line expressed both membrane bound and intracellular forms of FH and FHL1 (show FHL1 Proteins).

  6. High level of IL-6 is associated with obesity.

  7. An association has been found between IL6 gene -174G>C polymorphism and the development of nonalcoholic steatohepatitis in the Russian population.

  8. Helicobacter pylori-induced STAT3 (show STAT3 Proteins) activation is mediated, at least in part, through reactive oxygen species-induced upregulation of IL-6 expression.

  9. IL-6/NOS2 (show NANOS2 Proteins) inflammatory signals are involved in the regulation of MMP-9 (show MMP9 Proteins)- and MMP-2 (show MMP2 Proteins)-dependent metastatic activity and that high circulating nitrite levels innasopharyngeal carcinoma (NPC (show NPC1 Proteins)) patients may constitute a prognostic predictor for survival.

  10. These results suggest that the ingestion of a high (compared to low) CHO diet over a seven-day training period is ineffective in attenuating post-exercise IL-6 and hepcidin (show HAMP Proteins) responses. Such results may be due to the modest training load, the increased protein intake in the low-CHO trial, and a 48 h recovery period prior to sample collection on day 7, allowing a full recovery of muscle glycogen (show GYS1 Proteins) status between exercise sessi

Cow (Bovine) Interleukin 6 (IL6) interaction partners

  1. when a confluent endometrial epithelial cell barrier is faced with infection and damage, chemokines attract immune cells to the uterine lumen, but IL6 is solely secreted apically to ensure immune cells are only exposed to IL6 once they reach the lumen.

  2. The results revealed that the peak expression of IL6 and 21 was on DPV 28 which correlated well with the FMDV antibody titer and plummeted to the prevaccination titer level by 60 DPV.

  3. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  4. Testicular IL-1 alpha (show IL1A Proteins) and IL-1 beta (show IL1B Proteins) concentrations were highest in the early post-natal period; however, IL-1 (show IL1A Proteins) bioactivity and IL-6 concentrations were greatest in the immediate pre-pubertal period.

  5. The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A Proteins) was unaffected.[IL-6, IL-12 (show IL12A Proteins)]

  6. results show for the first time that interleukin-6 (IL6), in the presence of its soluble receptor (show IFNAR1 Proteins) (sIL-6R), induces activation of JAK1 (show JAK1 Proteins), JAK2 (show JAK2 Proteins), and STAT1 (show STAT1 Proteins)/STAT3 (show STAT3 Proteins) proteins in bovine articular chondrocytes.

  7. Mechanical injury potentiates the catabolic effects of TNFalpha (show TNF Proteins) and IL-6/sIL-6R in causing proteoglycan (show Vcan Proteins) degradation in human and bovine cartilage.

Rabbit Interleukin 6 (IL6) interaction partners

  1. Mild heat shock increased the production of inflammatory cytokines, IL-1beta (show IL1B Proteins) and IL-6 in rabbit cornea cells.

Pig (Porcine) Interleukin 6 (IL6) interaction partners

  1. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1 (show TGFB1 Proteins), IL-10 (show IL10 Proteins), and IL-6 in ovarian follicles are reported.

  2. Data suggest IL6 prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst viability via IL6/STAT3 (show STAT3 Proteins) (signal transducer/activator of transcription (show STAT1 Proteins) 3) signaling pathway (including up-regulation of STAT3 (show STAT3 Proteins) expression/phosphorylation).

  3. LIF (show LIF Proteins) and IL-6 are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.

  4. INFgamma and IL-6 modulate PPARs gene expression in the porcine endometrium during the estrous cycle and pregnancy.

  5. interleukin-6, endothelin ET-1 (show EDN1 Proteins), and apoptotic Bak (show BAK1 Proteins) and Bcl-XL (show BCL2L1 Proteins) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury

  6. Data show that all five molecules, BNP, ICAM-1 (show ICAM1 Proteins), TNF-alpha (show TNF Proteins), VCAM-1 (show VCAM1 Proteins) and IL-6, quickly and reliably signaled adverse interactions.

  7. IL-6 level from frozen peripheral blood mononuclear cells was significantly lower than that from fresh ones.

  8. These results suggest that TNF-alpha (show TNF Proteins) and IL-10 (show IL10 Proteins), but not IL-6, are involved in the late reparatory phases of the experimental disk lesion.

  9. These results suggest that IL-6 mRNA expression in porcine immune cells is cell-type specific and the results of this study could be used as the basis for research on the porcine immune system.

  10. role for IL-6 in the homeostatic modulation of aqueous humor outflow resistance

Goat Interleukin 6 (IL6) interaction partners

  1. Plasma nitric oxide acts as a regulator of cytokine function exhibiting negative feedback to maintain steady plasma IL-6 concentration in protein- or energy-restricted goats during late gestation.

Horse (Equine) Interleukin 6 (IL6) interaction partners

  1. These data suggest that IL-6 may play a key role in equine metabolic syndrome (EMS), and that pro-inflammatory cytokines levels in serum may serve as an additional tool for diagnosing EMS.

  2. IL-6 stimulation decreased chondrocyte expression of the canonical Wnt (show WNT2 Proteins) signaling pathway transactivator beta-catenin (show CTNNB1 Proteins), induced expression of inhibitors of the Wnt (show WNT2 Proteins) pathway, and increased expression of GDF-5 (show GDF5 Proteins).

  3. study shows that IL-6 is rapidly induced in BAL-cells of airway-compromised horses in response to adenosine exposure, probably through A2BAR (show ADORA2B Proteins) activation and that this effect can be modulated by A2AAR (show ADORA2A Proteins)

  4. Our data show the presence of a polymorphism downstream of the equine IL-6 gene that is associated with the basal Cu:Zn ratio in horses independent of breed.

  5. Expression levels of IL-6 are significantly increased in peripheral blood mononuclear cells from trained horses compared to sedentary animals.

  6. Failure of passive transfer may directly influence the serum IL-6 concentration in septic foals. Neither serum IL-6 nor IL-10 (show IL10 Proteins) alone, were useful diagnostic indices of sepsis in equine neonates.

  7. The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 (show IL10 Proteins) and TNF-alpha (show TNF Proteins), in horses with recurrent airway obstruction during exacerbation and in remission is reported.

Rainbow Trout (Oncorhynchus mykiss) Interleukin 6 (IL6) interaction partners

  1. IL6 mRNA abundance was significantly increased in spleen, liver, and gill of rainbow trout after experimental infection with Aeromonas salmonicida.

  2. in this paper we present for the first time in fish the functional characterisation of IL-6, using rainbow trout

  3. found that peptidoglycans derived from Gram-negative bacteria (Escherichia coli 0111:B4 and K12 (show KRT12 Proteins)), are potent inducers of IL-1beta (show IL1B Proteins) and IL-6 gene expression and were equal to, or more potent than, crude LPS (show IRF6 Proteins).

Interleukin 6 (IL6) Protein Profile

Protein Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.

Gene names and symbols associated with Interleukin 6 Proteins (IL6)

  • interleukin 6 (Il6)
  • interleukin 6 (interferon, beta 2) (IL6)
  • interleukin-6 (il-6)
  • BSF2 protein
  • CHIL-6 protein
  • HGF protein
  • HSF protein
  • IFNB2 protein
  • IL-6 protein
  • il6 protein
  • ILg6 protein

Protein level used designations for Interleukin 6 Proteins (IL6)

B-cell hybridoma growth factor , interleukin HP-1 , interleukin-6 , IL-6 , Interleukin 6 (interferon, beta 2) , B-cell differentiation factor , B-cell stimulatory factor 2 , BSF-2 , CDF , CTL differentiation factor , IFN-beta-2 , hybridoma growth factor , interferon beta-2 , interleukin BSF-2 , Anpl-IL*06-01 , interleukin-6 protein , interferon-beta-2

16193 Mus musculus
24498 Rattus norvegicus
3569 Homo sapiens
443406 Ovis aries
395337 Gallus gallus
280826 Bos taurus
403985 Canis lupus familiaris
101798321 Anas platyrhynchos
100008733 Oryctolagus cuniculus
399500 Sus scrofa
517016 Bos taurus
100860785 Capra hircus
100034196 Equus caballus
493687 Felis catus
705819 Macaca mulatta
101281783 Orcinus orca
100136689 Oncorhynchus mykiss
503562 Takifugu rubripes
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