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IL-6 Protein (AA 29-212)

IL6 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Catalog No. ABIN2018139
  • Target See all IL-6 (IL6) Proteins
    IL-6 (IL6) (Interleukin 6 (IL6))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 29-212
    Origin
    • 32
    • 18
    • 15
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 51
    • 24
    • 21
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Characteristics
    ED50 <0.1 ng/mL, measured by the dose-dependent stimulation of the proliferation of IL-6 dependent murine 7TD1 cells, corresponding to a specific activity of > 1 x 10^7 units/mg.
    AA 29-212, expressed with an N-terminal Met.
    Purity
    > 95 % by SDS-PAGE analysis.
    Endotoxin Level
    < 0.2 EU/μg, determined by LAL method.
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    Discover our top product IL6 Protein
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against 1xPBS.
    Storage
    -80 °C
    Storage Comment
    Lyophilized recombinant human Interleukin-6 (rhIL-6) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-6 should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Expiry Date
    6 months
  • Target
    IL-6 (IL6) (Interleukin 6 (IL6))
    Alternative Name
    Interleukin-6 (IL-6) (IL6 Products)
    Synonyms
    BSF2 Protein, HGF Protein, HSF Protein, IFNB2 Protein, IL-6 Protein, Il-6 Protein, ILg6 Protein, Ifnb2 Protein, il6 Protein, CHIL-6 Protein, interleukin 6 Protein, interleukin-6 Protein, IL6 Protein, Il6 Protein, il-6 Protein, IL-6 Protein
    Background
    Interleukin-6 (IL-6, also known as IFN-beta2) is a pleiotropic cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 is secreted by T cells and macrophages to stimulate immune response. IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. It supports the growth of B cells and is antagonistic to regulatory T cells.Recombinant human Interleukin-6 (rhIL-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 185 amino acids. A fully biologically active molecule, rhIL-6 has a molecular mass of 20.9 kDa analyzed by reducing SDS-PAGE.
    Synonyms: 26 kDa protein, IFN-beta2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
    Molecular Weight
    20.9 kDa, observed by reducing SDS-PAGE.
    UniProt
    Q75MH2
    Pathways
    TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
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