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Interleukin 8 Proteins (IL8)

The protein encoded by IL8 is a member of the CXC chemokine family. Additionally we are shipping Interleukin 8 Antibodies (548) and Interleukin 8 Kits (170) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse IL8 IL8 20309 Q9WVL7
IL8 3576 P10145
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Top Interleukin 8 Proteins at

Showing 10 out of 166 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag Interleukin 8 (IL8) (AA 23-99), (full length) protein (His tag) 50 μg Log in to see 9 to 11 Days
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Cynomolgus Un-conjugated 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Dog Un-conjugated 50 μg Log in to see 16 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 5 to 6 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   25 μg Log in to see 10 to 12 Days

IL8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , , ,
, ,
Dog (Canine) , ,

Top referenced Interleukin 8 Proteins

  1. Human Interleukin 8 Protein expressed in Human Cells - ABIN2002051 : Koch, Polverini, Kunkel, Harlow, DiPietro, Elner, Elner, Strieter: Interleukin-8 as a macrophage-derived mediator of angiogenesis. in Science (New York, N.Y.) 1993 (PubMed)
    Show all 5 references for ABIN2002051

  2. Dog (Canine) Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2008844 : Bar-Eli: Role of interleukin-8 in tumor growth and metastasis of human melanoma. in Pathobiology : journal of immunopathology, molecular and cellular biology 1999 (PubMed)
    Show all 5 references for ABIN2008844

  3. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2002054 : Baggiolini, Clark-Lewis: Interleukin-8, a chemotactic and inflammatory cytokine. in FEBS letters 1992 (PubMed)
    Show all 5 references for ABIN2002054

  4. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2666581 : Hess, Means, Autissier, Woodberry, Altfeld, Addo, Frahm, Brander, Walker, Luster: IL-8 responsiveness defines a subset of CD8 T cells poised to kill. in Blood 2004 (PubMed)
    Show all 4 references for ABIN2666581

  5. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN1305113 : Matsushima, Oppenheim: Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF. in Cytokine 1991 (PubMed)
    Show all 2 references for ABIN1305113

  6. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN1047264 : Van Damme, Rampart, Conings, Decock, Van Osselaer, Willems, Billiau: The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms. in European journal of immunology 1990 (PubMed)
    Show all 2 references for ABIN1047264

  7. Human Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN413549 : Reeves, Williamson, ONeill, Greally, McElvaney: Nebulized hypertonic saline decreases IL-8 in sputum of patients with cystic fibrosis. in American journal of respiratory and critical care medicine 2011 (PubMed)

  8. Cynomolgus Interleukin 8 Protein expressed in Escherichia coli (E. coli) - ABIN2010090 : Utgaard, Jahnsen, Bakka, Brandtzaeg, Haraldsen: Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells. in The Journal of experimental medicine 1998 (PubMed)

More Proteins for Interleukin 8 (IL8) Interaction Partners

Zebrafish Interleukin 8 (IL8) interaction partners

  1. Targeted expression of the human oncogene (show RAB1A Proteins) KRASG12V in zebrafish gills induces inflammation and cxcl8-l1 expression.

  2. Data show that both Cxcl8-l1 and Cxcl8-l2 are required for larva survival upon Salmonella Typhimurium infection.

  3. results explain how early H2O2 signal regulates neutrophil recruitment at all phases, directly via Lyn (show LYN Proteins) oxidation or indirectly by modulating cxcl8 gene expression

  4. The data identify HOXC9 (show HOXC9 Proteins) as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner

  5. Here, we report the characterisation of genes encoding the zebrafish Cxcl8, Cxcr1 (show CXCR1 Proteins) and Cxcr2 (show CXCR2 Proteins)

Mouse (Murine) Interleukin 8 (IL8) interaction partners

  1. Findings suggest that IL8-dependent osteoclast activation may constitute an early event in the initiation of the joint specific inflammation in anti-citrullinated protein-positive rheumatoid arthritis.

  2. Data suggest that CXCL1 (show CXCL1 Proteins)/IL-8, released from osteoclasts in an autoantibody-dependent manner, produces pain by activating sensory neurons.

  3. IL-8 signaling is up-regulated in alcoholic hepatitis.

  4. expressions of IL-1beta (show IL1B Proteins) and IL-8 in the brain increased after ApoE (show APOE Proteins) knockout in mice

  5. CYLD (show CYLD Proteins) negatively regulates nontypeable Haemophilus influenzae-induced IL-8 expression via MKP-1 (show DUSP1 Proteins)-dependent inhibition of ERK (show EPHB2 Proteins).

  6. Taken together, these results indicate that CD147 (show BSG Proteins) promotes lung cancer-induced osteoclastogenesis by modulating IL-8 secretion, and suggest that CD147 (show BSG Proteins) is a potential therapeutic target for cancer-associated bone resorption in lung cancer patients.

  7. these data outline a novel role for the P2Y6 receptor (show P2RY6 Proteins) in the induction of CXCL8/IL-8 production and barrier dysfunction in response to C. difficile toxin exposure and may provide a new therapeutic target for the treatment of CDI.

  8. these data suggest that IL-8 plays an important role in breast cancer osteolysis

  9. T. crispa ethanol extract fraction was used to investigate the potential immunomodulatory effect of different T. crispa doses ranging from 25 mug/mL to 1000 mug/mL on RAW 246.7 cells by detecting intracellular INF (show GIF Proteins)-gamma, IL-6 (show IL6 Proteins), and IL-8 expressions.

  10. We found that IL-33 (show IL33 Proteins) could induce and enhance the expression of IL-6 (show IL6 Proteins) and IL-8 in PBMCs of COPD (show ARCN1 Proteins) mice via p38 MAPK (show MAPK14 Proteins) pathway.

Human Interleukin 8 (IL8) interaction partners

  1. The levels of IL-8, IL-12 (show IL12A Proteins), and adrenomedullin (show ADM Proteins) may be good indicators of embryo and oocyte quality in endometriosis patients undergoing IVF (show SCN5A Proteins).

  2. our study provided the evidence of association between the polymorphisms of IL-8 -251 rs4073 and +781 rs2227306 and the risk of osteosarcoma and found that the IL-8 -251 A/T genotype was associated with increased risk for development and metastasis of osteosarcoma in Chinese Han population.

  3. High IL8 expression is associated with gastric cancer.

  4. Necrotic cells induced NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins) activation and their binding to the IL-8 promoter, leading to enhanced IL-8 production and secretion in glioblastoma multiforme cells.

  5. Study provides indication that the IL-8 -251A/T polymorphism may be associated with periodontitis in Asian and mixed populations. [meta-analysis]

  6. IL-8 rs4073 polymorphism could be a marker for primary gouty arthritis development.

  7. Findings suggest that the IL-8 -251A/T polymorphism constitutes an independent risk factor for coronary artery disease susceptibility in a Chinese population.

  8. cells. As such, we demonstrated that IL-8 expression is regulated through MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins)-dependent pathways in TNBC cells. A diversity of MEK (show MAP2K1 Proteins) blockers, including UO126, may be promising for treating TNBC patients.

  9. The results of western blotting revealed that the protein expression levels of FH and FHL1 (show FHL1 Proteins) were not regulated by IL6 (show IL6 Proteins) and IL8 in a dosedependent manner. Immunofluorescence analysis confirmed that the A2780 ovarian cancer cell line expressed both membrane bound and intracellular forms of FH and FHL1 (show FHL1 Proteins).

  10. Tumor-associated macrophage-secreted CXCL8 downregulated the ERalpha (show ESR1 Proteins) expression of endometrial cancer cells via HOXB13 (show HOXB13 Proteins), which may be associated with cancer invasion, metastasis and poor prognosis.

Cow (Bovine) Interleukin 8 (IL8) interaction partners

  1. In response to C. abortus infection, both ovine and bovine turbinate cells produce CXCL8 mRNA and protein late in the bacterial developmental cycle.

  2. Studied association of IL8 -105G/A with mastitis somatic cell score in Chinese Holstein dairy cows. Results suggest genotype GG may be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein dairy cows.

  3. Data implicate a complex cascade of events during luteolysis, involving Il8 signaling, neutrophil recruitment, and immune cell action within the corpus luteum.

  4. Cadmium exposure induced pulmonary inflammation and increased lung interleukin 8 secretion.

  5. Exposure to follicular fluid transiently increased the transcript levels of IL8 and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1 (show NR3C1 Proteins). TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  6. study demonstrates that a small experimental rodent model can be utilized for non-invasively monitoring, through a reporter gene system, the activation of an IL-8 promoter region derived from a larger size animal (bovine)

  7. Finding of genetic variation in the IL8 promoter that differentially regulates its expression has significant functional implications for IL8 expression in vitro and which may impact on susceptibility to infectious disease and inflammation.

  8. Polymorphonuclear neutrophils migrate into the early corpus luteum(CL) partially due to its major chemoattractant IL-8 produced at high levels in the CL.

  9. IL8 genotype significantly correlated with mastitis resistance and the locus could be a useful genetic marker for mastitis resistance selection and breeding in Chinese Holstein.

  10. IL8 promoter serial deletion analysis revealed a specific region responsive to ORF50/Rta (show RBM9 Proteins); may represent an endometrial defense mechanism against viral infection

Pig (Porcine) Interleukin 8 (IL8) interaction partners

  1. These results suggest that porcine circovirus 2 induces IL-8 secretion via the TLR2/MyD88 (show MYD88 Proteins)/NF-kappaB (show NFKB1 Proteins) signalling pathway.

  2. Facilitated degradation of the RGS16 (show RGS16 Proteins) by porcine circovirus type 2 ORF3 further enhances NFkappaB translocation into the nucleus through the ERK1/2 signalling pathway and increased IL-6 (show IL6 Proteins) and IL-8 mRNA transcripts.

  3. Suggest that the interplay between TGFbeta (show TGFB1 Proteins)-2 and LPS (show IRF6 Proteins) regulates the levels of IL-8 in the immature newborn intestine.

  4. Data suggest that MSK1 (show RPS6KA5 Proteins) and MSK2 are the major CREB (show CREB1 Proteins) kinases in fibroblast-like synoviocytes from rheumatoid arthritis patients stimulated with lysophosphatidic acid and that phosphorylation of CREB1 (show CREB1 Proteins) at Ser (show SIGLEC1 Proteins)-133 plays a significant role in IL-8 production.

  5. Study presents evidence demonstrating a single species of exotoxin ApxI, derived from A. pleuropneumoniae serotype 10, induces the expression and production of proinflammatory cytokines IL-1beta (show IL1B Proteins), IL-8 and TNF-alpha (show TNF Proteins) in porcine alveolar macrophages.

  6. local expression of IL-1beta (show IL1B Proteins) and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls

  7. In swine, IL-8, TNF-ALPHA (show TNF Proteins), INOS (show NOS2 Proteins) AND MIP-1BETA (show CCL4 Proteins) were increased during mechanical ventilation in a time-related fashion.

  8. Classical swine fever virus NS2 protein promotes interleukin-8 expression.

  9. Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth

Rabbit Interleukin 8 (IL8) interaction partners

  1. At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold

  2. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1 (show CCL2 Proteins)) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.

  3. The JNK (show MAPK8 Proteins) pathway plays an important role in mechanical ventilation-stimulated TNF-alpha (show TNF Proteins) expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.

  4. IL-8 and IL-1ra (show IL1RN Proteins) showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis

Horse (Equine) Interleukin 8 (IL8) interaction partners

  1. Results suggested that chemokine (show CCL1 Proteins) expression by cultured equine BECs following exposure to pulmonary hemorrhage conditions may contribute to the development of inflammatory airway disease in horses.

  2. Mapped six genes (EIF4G3 (show EIF4G3 Proteins), HSP90 (show HSP90AB1 Proteins), RBBP6 (show RBBP6 Proteins), IL8, TERT (show TERT Proteins), and TERC) on the chromosomes of Equus caballus, Equus asinus, Equus grevyi, and Equus burchelli by fluorescence in situ hybridization.

  3. This study examined effects of in vitro exposure to solutions of hay (show GTF2H5 Proteins) dust, lipopolysaccharides, or beta-glucan on cytokine expression in pulmonary mononuclear cells isolated from healthy horses and horses with recurrent airway obstruction.

  4. These results suggest that MMP-1 (show MMP1 Proteins) and IL-8 are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Rhesus Monkey Interleukin 8 (IL8) interaction partners

  1. Stress decreased IL-8 gene expression in both CeA (show CEACAM3 Proteins) lesioned and non-lesioned animals. But, CeA (show CEACAM3 Proteins) lesions increased the tissue expression of IL-8 mRNA prior to and after stress exposure.

Duck Interleukin 8 (IL8) interaction partners

  1. Duck IL-8 is good immunostimulant to enhance the immune efficiency of avian influenza vaccine in ducks.

Interleukin 8 (IL8) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.

Gene names and symbols associated with Interleukin 8 Proteins (IL8)

  • interleukin 8-like 1 (IL8L1)
  • interleukin 8 (il8)
  • interleukin 8 (IL8)
  • chemokine (C-X-C motif) ligand 1-like (LOC422654)
  • chemokine (C-X-C motif) ligand 15 (Cxcl15)
  • interleukin 8 (Il8)
  • interleukin 8-like 2 (IL8L2)
  • interleukin-8-like (IL*08-02)
  • AMCF-I protein
  • CXCL8 protein
  • cxcli2 protein
  • EMF-1 protein
  • GCP-1 protein
  • GCP1 protein
  • IL-8 protein
  • Il8 protein
  • interleukin-8 protein
  • K60 protein
  • LECT protein
  • LUCT protein
  • lungkine protein
  • LYNAP protein
  • MDNCF protein
  • MONAP protein
  • NAF protein
  • NAP-1 protein
  • NAP1 protein
  • Scyb15 protein
  • si:dkey-151b16.2 protein
  • weche protein

Protein level used designations for Interleukin 8 Proteins (IL8)

CXC chemokine K60 , interleukin 8 , interleukin-8 , cxcl-chr1b , cxcl8 , IL-8 , C-X-C motif chemokine 15 , small inducible cytokine subfamily B, member 15 , small-inducible cytokine B15 , T-cell chemotactic factor , alveolar macrophage chemotactic factor I , beta endothelial cell-derived neutrophil activating peptide , beta-thromboglobulin-like protein , chemokine (C-X-C motif) ligand 8 , emoctakin , granulocyte chemotactic protein 1 , lung giant cell carcinoma-derived chemotactic protein , lymphocyte derived neutrophil activating peptide , monocyte-derived neutrophil chemotactic factor , monocyte-derived neutrophil-activating peptide , neutrophil-activating peptide 1 , small inducible cytokine subfamily B, member 8 , tumor necrosis factor-induced gene 1 , C-X-C motif chemokine 8 , neutrophil activating peptide 1 , alveolar macrophage-derived chemotactic factor-I , NAP-1 , PF1 , RPF1 , neutrophil attractant/activation protein 1 , neutrophil attractant/activation protein-1 , permeability factor 1 , Interleukin-8-like protein , Neutrophil attractant protein 1 , neutrophil attractant protein-1 , interlukin-8 , 9E3 , CEF-4 , CEF-4/9E3 cytokine , RSV-induced protein , embryo fibroblast protein 1 , putatitve interleukin-8 , transformation-induced protein , Anpl-IL*08-03

395872 Gallus gallus
445923 Takifugu rubripes
471205 Pan troglodytes
100002946 Danio rerio
100034742 Meleagris gallopavo
100381196 Papio anubis
422654 Gallus gallus
20309 Mus musculus
3576 Homo sapiens
280828 Bos taurus
443418 Ovis aries
396880 Sus scrofa
403850 Canis lupus familiaris
100009129 Oryctolagus cuniculus
100037400 Equus caballus
100379599 Cavia porcellus
493836 Felis catus
613028 Macaca mulatta
101441641 Dasypus novemcinctus
101331085 Tursiops truncatus
396495 Gallus gallus
101804010 Anas platyrhynchos
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