anti-Laminin, gamma 1 (LAMC1) Antibodies

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. Additionally we are shipping Laminin gamma 1 Proteins (13) and Laminin gamma 1 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LAMC1 226519  
LAMC1 117036  
LAMC1 3915 P11047
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Top anti-Laminin gamma 1 Antibodies at

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-LAMC1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Human Muscle 100 μL Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-LAMC1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Human Placenta 100 μL Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged LAMC1 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
Human Mouse Un-conjugated EIA, IHC (fro), IP   0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-Laminin gamma 1 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-Laminin gamma 1 antibody, Western blotting Lane 1: Rat Kidney Tissue Lysate Lane 2: Rat Lung Tissue Lysate Lane 3: U87 Cell Lysate Lane 4: SMMC Cell Lysate Lane 5: HELA Cell Lysate Lane 6: SKOV1 Cell Lysate 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Laminin gamma 1 Antibody [NBP1-87719] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10.Lane 2: Human cell line RT-4 Immunohistochemistry: Laminin gamma 1 Antibody [NBP1-87719] - Staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells. 0.1 mL Log in to see 10 to 13 Days
Human Rabbit Un-conjugated IHC, IHC (p), SimWes, WB Western Blot: Laminin gamma 1 Antibody [NBP1-87718] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells); Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells). Simple Western: Laminin gamma 1 Antibody [NBP1-87718] - Simple Western lane view shows a specific band for LAMC1 in 0.2 mg/ml of RT-4 (left) and U-251MG sp (right) lysate. This experiment was performed under reducing conditions using the 66-440 kDa separation system. 0.1 mL Log in to see 10 to 13 Days
Mouse Rabbit Un-conjugated IHC (fro), IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc cells, using LAMC1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days

LAMC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , , , ,
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Rat (Rattus)
Human , , , ,
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Top referenced anti-Laminin gamma 1 Antibodies

  1. Human Polyclonal Laminin gamma 1 Primary Antibody for IHC (p), WB - ABIN3043157 : Chen, Wan, Xia, Guo, Wang, Liu, Li: Promoted regeneration of mature blood vessels by electrospun fibers with loaded multiple pDNA-calcium phosphate nanoparticles. in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fu?r Pharmazeutische Verfahrenstechnik e.V 2013 (PubMed)
    Show all 13 Pubmed References

  2. Human Polyclonal Laminin gamma 1 Primary Antibody for IHC, IHC (p) - ABIN4330132 : Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012 (PubMed)

  3. Human Polyclonal Laminin gamma 1 Primary Antibody for IHC, IHC (p) - ABIN4330131 : Kuhn, Kurman, Soslow, Han, Sehdev, Morin, Wang, Shih: The diagnostic and biological implications of laminin expression in serous tubal intraepithelial carcinoma. in The American journal of surgical pathology 2012 (PubMed)

More Antibodies against Laminin gamma 1 Interaction Partners

Mouse (Murine) Laminin, gamma 1 (LAMC1) interaction partners

  1. Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 (show NRG1 Antibodies) type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.

  2. Analysis of nidogen-1 (show NID1 Antibodies) and laminin-gamma1 interaction reveals multiple binding modes.

  3. The C-terminal domains of mouse laminin gamma 1 and nidogen 1 (show NID1 Antibodies) mediate interactions complex formation.

  4. STI1 (show STIP1 Antibodies) and Ln-gamma1 promote robust axonogenesis in wild-type neurons, whereas no effect is observed in neurons from PrPC (show PRNP Antibodies)-null mice.

  5. Data show that expression of either mGluR1 (show GRM1 Antibodies) or mGluR5 (show GRM5 Antibodies) in HEK293 cells reconstituted the signaling pathways mediated by PrP(C (show PRNP Antibodies))-Ln gamma1 peptide interaction.

  6. Laminin beta(1 (show LAMB1 Antibodies)) and gamma(1) N-terminal domains share the galactose-binding domain-like fold.

  7. Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.

  8. structure of the interacting domains reveals a six-bladed Tyr (show TYR Antibodies)-Trp (show TYRP1 Antibodies)-Thr (show TRH Antibodies)-Asp (show C3 Antibodies) (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor (show EGF Antibodies)-like (LE) modules III3-5 in laminin (LE3-5)

  9. This study demonstrates (1) that laminin initiates axonal sorting and mediates axon-Schwann cell interactions required for Schwann cell proliferation and differentiation. (2) that laminin provides a PI3-kinase (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)-mediated Schwann cell survival signal.

  10. netrin-4 (show NTN4 Antibodies) is a component of basement membranes and is integrated into the laminin polymer via interactions with the laminin gamma1 andgamma3 short arms

Zebrafish Laminin, gamma 1 (LAMC1) interaction partners

  1. Two zebrafish loci, grumpy (show LAMB1 Antibodies) and sleepy, encode laminin beta1 and laminin gamma1, respectively. These genes are required for the formation of the laminin-dependent basement membrane is essential for the differentiation of chordamesoderm to notochord.

Human Laminin, gamma 1 (LAMC1) interaction partners

  1. Further gene expression analyses demonstrated significantly higher expression of LAMC1 gene in colorectal cancer (CRC (show CALR Antibodies)) tumor tissues than that in adjacent non-cancerous tissues (P = 0.0004). These findings strongly suggest that the functional SNP located at TFBSs, rs6695837 might contribute to CRC (show CALR Antibodies) susceptibility, and the exact biological mechanism awaits further research.

  2. The rs780094 [1.34 (1.21-1.49); p = 8.57 x 10(-8) ] on chr 2 at the glucokinase regulatory protein (GCKR (show GCKR Antibodies)) locus was similarly significantly associated, while the rs10911205 [1.29 (1.16-1.44); p = 3.52 x 10(-6) ] on chr1 at the laminin subunit gamma-1 (LAMC1) locus showed suggestive association with disease.

  3. Our results show that miR (show MLXIP Antibodies)-181a is down-regulated in glioblastoma multiforme (GBM) patients. The three target genes, ANGPT2 (show ANGPT2 Antibodies), ARHGAP18 (show ARHGAP18 Antibodies) and LAMC1, are negatively correlated with the expression of miR (show MLXIP Antibodies)-181a. Moreover, high expression of ANGPT2 (show ANGPT2 Antibodies) or LAMC1 together with large size of GBM is correlated with a shorter median overall survival

  4. miR (show MLXIP Antibodies)-506 acts as a tumor suppressor and inhibits malignancy of colorectal cancer cells through directly targeting LAMC1.

  5. Case Report: Anti-laminin-gamma 1 pemphigoid in patient with generalized pustular psoriasis and psoriasis vulgaris.

  6. The identification of laminin gamma 1 (LAMC1) and myeloid cell leukemia 1 (MCL1 (show MCL1 Antibodies)) as direct targets of miR (show MLXIP Antibodies)-22 and miR (show MLXIP Antibodies)-29a, respectively, suggested a tumor-suppressive role of these miRNAs.

  7. LAMC1 may contribute to the development and progression of uterine carcinoma, likely through enhancing tumor cell motility and invasion.

  8. Case Report: occurrence of anti-laminin-gamma1 pemphigoid in a case of autosomal recessive congenital ichthyosis (show LBR Antibodies).

  9. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146 (show MCAM Antibodies)).

  10. Data showed that LAMC1 expression is directly regulated by miR (show MLXIP Antibodies)-29s.

Laminin gamma 1 (LAMC1) Antigen Profile

Protein Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.

Gene names and symbols associated with LAMC1

  • laminin gamma-1 chain (Smp_163810) antibody
  • laminin, gamma 1 (lamc1) antibody
  • laminin, gamma 1 (Lamc1) antibody
  • laminin, gamma 1 (formerly LAMB2) (LAMC1) antibody
  • laminin, gamma 1 (formerly LAMB2) (Lamc1) antibody
  • B2e antibody
  • LAMB2 antibody
  • sly antibody

Protein level used designations for LAMC1

laminin gamma-1 chain , laminin subunit gamma-1 , S-LAM gamma , S-laminin subunit gamma , laminin B2 chain , laminin-1 subunit gamma , laminin-10 subunit gamma , laminin-11 subunit gamma , laminin-2 subunit gamma , laminin-3 subunit gamma , laminin-4 subunit gamma , laminin-6 subunit gamma , laminin-7 subunit gamma , laminin-8 subunit gamma , laminin-9 subunit gamma , shortstop , shp , sleepy

8355738 Schistosoma mansoni
100036631 Xenopus (Silurana) tropicalis
226519 Mus musculus
117036 Rattus norvegicus
286832 Danio rerio
3915 Homo sapiens
100734278 Cavia porcellus
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