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Melanocortin 4 Receptor Proteins (MC4R)

The protein encoded by MC4R is a membrane-bound receptor and member of the melanocortin receptor family. Additionally we are shipping Melanocortin 4 Receptor Antibodies (119) and Melanocortin 4 Receptor Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MC4R 4160 P32245
MC4R 17202 P56450
MC4R 25635 P70596
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Top Melanocortin 4 Receptor Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

MC4R Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for Melanocortin 4 Receptor (MC4R) Interaction Partners

Zebrafish Melanocortin 4 Receptor (MC4R) interaction partners

  1. MRAP2b decreases the constitutive activity of the MC4R during fasting periods, driving the animal toward a positive energy balance.

  2. MRAP2 proteins allow for developmental control of MC4R activity, with MRAP2a blocking its function and stimulating growth during larval development, whereas MRAP2b enhances responsiveness to alpha-MSH once the zebrafish begins feeding, thus increasing the capacity for regulated feeding and growth.

Human Melanocortin 4 Receptor (MC4R) interaction partners

  1. The MC4R variant (rs12970134) was associated with increased risk for obesity in Czech women.

  2. Uncontrolled eating scores were higher in C-allele carriers of MC4R-rs17782313 compared to non-carriers.

  3. Data show that co-expression with MRAPalpha, but not MRAP2, enhances MC4R constitutive activity. MRAPalpha-enhanced MC4R constitutive activity is not dependent on MC4R complex glycosylation but may result from MRAPalpha-induced changes in MC4R conformational states.

  4. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis--{REVIEW}

  5. MC4R (melanocortin-4 receptor) rs17782313 gene polymorphism is associated with higher triglyceride levels in older Chinese women

  6. The variant rs17782313 OF mc4r is associated with an increased risk of hypertriglyceridemia in obese children and adolescents

  7. Obese children carrying the FTO (show FTO Proteins) GG and/or the MC4R CC genotype lost more body weight in comparison to non-carriers from a lifestyle intervention.

  8. The interaction between FTO (show FTO Proteins) and MC4R polymorphisms is associated with the development of PCOS.

  9. The age of obesity onset in the present child generation of MC4R mutation carriers is decreasing compared to the age of onset in their parents' generation.

  10. FTO (show FTO Proteins) homozygotes and FTO (show FTO Proteins) heterozygotes correspond to 18.0% and 45.9% of neonates, respectively. MC4R homozygotes and MC4R heterozygotes were identified in 6.7% and 36.3% of neonates, respectively

Mouse (Murine) Melanocortin 4 Receptor (MC4R) interaction partners

  1. Mc4r receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling.

  2. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R-SphK1 (show SPHK1 Proteins) signaling.

  3. Our findings support the hypothesis that MC4R signaling in the pedunculopontine tegmental nucleus may involve in the modulation of midbrain dopamine systems.

  4. These results indicate that intact CNS MC4R signaling is necessary for leptin (show LEP Proteins) to exert its chronic antidiabetic, anorexic, and cardiovascular actions.

  5. Mc4r signaling has a protective role in minimizing glucose fluctuations due to circadian rhythms and environmental light cues, a previously undiscovered connection between circadian biology and glucose metabolism mediated through the melanocortin system.

  6. MC4R specifically inhibited the presynaptic N-type channel subtype, and this inhibition may be important for the effects of melanocortin in the central subdivision of the amygdala

  7. Coupling of MC4R to Kir7.1 (show KCNJ13 Proteins) may explain unusual aspects of the control of energy homeostasis by melanocortin signalling, including the gene dosage effect of MC4R and the sustained effects of AgRP (show AGRP Proteins) on food intake.

  8. The MC4R-expressing neurons regulating feeding are SIM1 (show SIM1 Proteins)(+), located in the paraventricular hypothalamus, glutamatergic and not GABAergic, and do not express oxytocin, corticotropin-releasing hormone (show CRH Proteins), vasopressin (show AVP Proteins), or prodynorphin (show PDYN Proteins).

  9. These findings highlight an essential, and to our knowledge previously unknown, role for Ca(2 (show CA2 Proteins)+) signaling in the MC4R pathway that leads to satiety, and a novel non-redundant role for NCKX4 (show Slc24a4 Proteins)-mediated Ca(2 (show CA2 Proteins)+) extrusion in controlling MC4R signaling

  10. Posttranscriptional decrease of MC4R protein lowers the response to alpha-MSH in hypothalamic neurons exposed to even a mild level of lipid stress.

Cow (Bovine) Melanocortin 4 Receptor (MC4R) interaction partners

  1. The MC4R gene may thus be a candidate gene for carcass traits with MC4R single nucleotide polymorphisms being potentially valuable as genetic markers for economic traits in Hanwoo.

  2. The aim was to estimate the frequency of the SNPs in the MC4R gene and to determine if individual genotypes were associated with several economic traits.

  3. The results suggested that -129A>G and 1,069C>G single nucleotide polymorphism of the MC4R gene may be useful as a genetic marker for carcass and meat quality traits in Qinchuan cattle.

  4. results are suggestive that adrenal glucocorticoid production could be regulated through melanocortin 4 receptor

  5. Single nucleotide polymorphisms in 5'-untranslated region of MC4R gene, were detected.

Pig (Porcine) Melanocortin 4 Receptor (MC4R) interaction partners

  1. These results indicate that genetic selection against boar taint is possible using MC4R as a marker.

  2. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  3. Transcriptional profiling was used to identify genes and pathways that responded to intracerebroventricular injection of MC4R agonist [Nle(4), d-Phe(7)]-alpha-melanocyte stimulating hormone (show POMC Proteins) in pigs homozygous for the missense mutation in the MC4R.

  4. study did not find any significant associations for polymorphisms in insulin (show INS Proteins)-like grwoth factor 2, GTP Binding Protein (show RND1 Proteins) alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs

  5. Linkage disequilibrium analysis among MC4R, LEP (show LEP Proteins) and H-FABP (show FABP3 Proteins) revealed that these genes were independent.

  6. The c.1426G>A polymorphism affects daily gain, feed conversion ratio and ham weight in both breeds, lean cuts in the Italian Duroc and backfat thickness in the Italian Large White.

  7. MC4R allelic variants had no effects on meat quality traits.

  8. The effects of missense mutations of MC4R on carcass composition, growth traits and meat quality in 1191 gilts of five swine breeds are reported.

  9. No effect of the MC4R trait nucleotides could be seen on muscle growth.

  10. Results of associated analysis show that the polymorphism of MC4R gene was associated traits of back fat thickness (BF).

Melanocortin 4 Receptor (MC4R) Protein Profile

Protein Summary

The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.

Gene names and symbols associated with Melanocortin 4 Receptor Proteins (MC4R)

  • melanocortin 4 receptor (mc4r)
  • melanocortin 4 receptor (MC4R)
  • melanocortin 4 receptor (LOC100218148)
  • melanocortin 4 receptor (Mc4r)
  • LOC100218148 protein
  • Mc4-r protein
  • MC4R protein
  • si:dkey-151m6.62 protein
  • zMC4 protein

Protein level used designations for Melanocortin 4 Receptor Proteins (MC4R)

melanocortin receptor 4 , melanocortin 4-receptor , melanocortin 4 receptor , melanocortin-4 receptor , Melanocortin receptor 4 , MC4-R

286833 Danio rerio
428485 Gallus gallus
445900 Takifugu rubripes
468556 Pan troglodytes
483961 Canis lupus familiaris
698596 Macaca mulatta
100016168 Monodelphis domestica
100147707 Ovis aries
100218148 Taeniopygia guttata
100379598 Cavia porcellus
4160 Homo sapiens
17202 Mus musculus
25635 Rattus norvegicus
281300 Bos taurus
397359 Sus scrofa
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