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Methylenetetrahydrofolate Reductase (NAD(P)H) Proteins (MTHFR)

The protein encoded by MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Additionally we are shipping MTHFR Antibodies (103) and MTHFR Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTHFR 17769 Q9WU20
MTHFR 4524 P42898
Rat MTHFR MTHFR 362657  
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Top MTHFR Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

MTHFR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

More Proteins for Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) Interaction Partners

Mouse (Murine) Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) interaction partners

  1. Study demonstrated that maternal MTHFR deficiency (i.e., in utero MTHFR deficiency) and early life exposure to vigabatrin separately and together alter the levels of proteins in the glutamatergic synapse

  2. Mildly hyperhomocysteinemic Mthfr+/- mice demonstrate reduced ganglion cell function, thinner NFL (show NEFL Proteins), and mild vasculopathy by 24 weeks.

  3. DNA methylation (show HELLS Proteins) patterns in undifferentiated spermatogonia are relatively stable in culture over time under conditions of altered methionine and MTHFR levels.

  4. Data from Mthfr knockout mice (in homozygous/heterozygous matings) suggest that maternal genotype contributes to sensitivity to arsenic as embryotoxin (i.e., genetic predisposition to fetal resorption/congenital malformation in arsenic poisoning).

  5. our results support an interaction between mild neonatal stress, the MTHFR genotype and sex

  6. investigation of Mthfr regulation in an in vivo mouse model revealed temporal- and tissue-specific regulation that supports important roles for MTHFR in the developing embryo, and in postnatal brain and male reproductive tissues

  7. A possible mechanism for the epigenetic involvement of Mthfr deficiency is proposed in the gender-dependent regulation of proteins associated with plasticity of the excitatory synapse.

  8. These results showed that methylenetetrahydrofolate reductase deficiency impairs endothelial progenitor cell formation and increases endothelial progenitor cell senescence by endothelial nitric oxide synthase (show NOS3 Proteins) uncoupling and downregulation of SIRT1 (show SIRT1 Proteins).

  9. Variable presentation of MTHFR deficiency in different genetic backgrounds; plasma homocysteine is not a predictor of severity.

  10. Newborn reflex development was slightly influenced by Mthfr +/- genotype and by the combination genotype and the neonatal vigabatrin (GVG) administration, in a sex-independent manner. Females presented attenuated anxiety due to Mthfr +/- genotype and GVG.

Human Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) interaction partners

  1. The prognostic index comprising XRCC1 (show XRCC1 Proteins) rs25487, ERCC2 (show ERCC2 Proteins) rs13181, and rs1799793 polymorphisms may be a useful predictor of clinical outcomes in MGC treated with EOF.

  2. The prevalence of factor V G1691A, prothrombin (show F2 Proteins) G20210A and MTHFR C677T single nucleotide polymorphism among Syrians is 11.5%, 2.5% and 84.5%, respectively.

  3. MTHFR C677T polymorphism, qualitatively, is not a genetic factor for the pathogenesis of psoriasis but could quantitatively reflect the severity of psoriasis to some extent. Meta-analysis.

  4. the studied polymorphisms MTHFR C677T (rs1801133) and MTR (show MTR Proteins) A2756G (rs1805087) do not contribute to genetic susceptibility to varicose veins in ethnical Russians.

  5. the influence of polymorphisms in methylenetetrahydrofolate reductase (MTHFR-C677T) and apolipoprotein-E (apo-E (show APOE Proteins)) as risk factors for ischemic stroke patients in south Indian population

  6. Rheumatoid arthritis patients with the MTHFR 677TT genotype had the highest asymmetric dimethylarginine levels, significantly higher than either those patients carrying the MTHFR 677CT or the MTHFR 677CC genotype.

  7. There is an association between variants of the MTHFR gene and hypertension in Cameroonian patients from the South West region.

  8. There were no other associations between single -nucleotide polymorphisms and the efficacy of MTX (show MTX1 Proteins) treatment. CONCLUSIONS: The MTHFR 677CC and GGH (show GGH Proteins) 401TT and CT genotypes were associated with a reduction in the number of MTX (show MTX1 Proteins)-related adverse events.

  9. Frequency of MTHFR risk allele (T) in patients with maternal age <25 years is marginally significant higher than those in cases with maternal age >/=25 years (p = .069) with an OR of 2.7 (95% CI = 0.90-8.07). Conclusions: MTHFR is a common susceptibility factor for gastroschisis in Indonesia.

  10. The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR c.677C>T p.A222V(rs1801133), TP53 (show TP53 Proteins) c.215C>G p.R72P (rs1042522), NQO1 (show NQO1 Proteins) c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 Proteins) alleles imputed as fast acetylator genotypes. [meta-analysis]

MTHFR Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Gene names and symbols associated with MTHFR

  • methylenetetrahydrofolate reductase (NAD(P)H) (mthfr)
  • methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR)
  • methylenetetrahydrofolate reductase (metF)
  • methylenetetrahydrofolate reductase (DDB_G0279137)
  • 5,10-methylenetetrahydrofolate reductase (Mthfr)
  • methylenetetrahydrofolate reductase (NAD(P)H) (Mthfr)
  • AI323986 protein
  • DDBDRAFT_0204686 protein
  • DDBDRAFT_0230137 protein
  • DDB_0204686 protein
  • DDB_0230137 protein

Protein level used designations for MTHFR

5,10-methylenetetrahydrofolate reductase , 5,10-methylenetetrahydrofolate reductase (NADPH) , methylenetetrahydrofolate reductase (NAD(P)H) , methylenetetrahydrofolate reductase-like , methylenetetrahydrofolate reductase

379784 Xenopus laevis
469800 Pan troglodytes
100125082 Xenopus (Silurana) tropicalis
100391000 Callithrix jacchus
1209960 Coxiella burnetii RSA 493
8621890 Dictyostelium discoideum AX4
17769 Mus musculus
4524 Homo sapiens
362657 Rattus norvegicus
478230 Canis lupus familiaris
397180 Sus scrofa
497032 Bos taurus
419489 Gallus gallus
100715703 Cavia porcellus
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