You are viewing an incomplete version of our website. Please click to reload the website as full version.

Methylenetetrahydrofolate Reductase (NAD(P)H) Proteins (MTHFR)

The protein encoded by MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Additionally we are shipping MTHFR Antibodies (103) and MTHFR Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTHFR 17769 Q9WU20
MTHFR 4524 P42898
Rat MTHFR MTHFR 362657  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top MTHFR Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MTHFR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) Interaction Partners

Mouse (Murine) Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) interaction partners

  1. Study demonstrated that maternal MTHFR deficiency (i.e., in utero MTHFR deficiency) and early life exposure to vigabatrin separately and together alter the levels of proteins in the glutamatergic synapse

  2. Mildly hyperhomocysteinemic Mthfr+/- mice demonstrate reduced ganglion cell function, thinner NFL (show NEFL Proteins), and mild vasculopathy by 24 weeks.

  3. DNA methylation (show HELLS Proteins) patterns in undifferentiated spermatogonia are relatively stable in culture over time under conditions of altered methionine and MTHFR levels.

  4. Data from Mthfr knockout mice (in homozygous/heterozygous matings) suggest that maternal genotype contributes to sensitivity to arsenic as embryotoxin (i.e., genetic predisposition to fetal resorption/congenital malformation in arsenic poisoning).

  5. our results support an interaction between mild neonatal stress, the MTHFR genotype and sex

  6. investigation of Mthfr regulation in an in vivo mouse model revealed temporal- and tissue-specific regulation that supports important roles for MTHFR in the developing embryo, and in postnatal brain and male reproductive tissues

  7. A possible mechanism for the epigenetic involvement of Mthfr deficiency is proposed in the gender-dependent regulation of proteins associated with plasticity of the excitatory synapse.

  8. These results showed that methylenetetrahydrofolate reductase deficiency impairs endothelial progenitor cell formation and increases endothelial progenitor cell senescence by endothelial nitric oxide synthase (show NOS3 Proteins) uncoupling and downregulation of SIRT1 (show SIRT1 Proteins).

  9. Variable presentation of MTHFR deficiency in different genetic backgrounds; plasma homocysteine is not a predictor of severity.

  10. Newborn reflex development was slightly influenced by Mthfr +/- genotype and by the combination genotype and the neonatal vigabatrin (GVG) administration, in a sex-independent manner. Females presented attenuated anxiety due to Mthfr +/- genotype and GVG.

Human Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) interaction partners

  1. we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR (show MTR Proteins) A2756G, rs1805087) polymorphisms and risk for thyroid and breast cancer. We found an association between MTHFR C677T polymorphism and risks to both thyroid (OR = 2.50; 95%CI = 1.15-5.46; P = 0.02) and breast cancer (OR = 2.53; 95%CI = 1.08-5.93; P = 0.03).

  2. Significant interactions were observed among the methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C) and cystathionine-beta-synthase (CBS (show CBS Proteins); T833C/844ins68, G919A) polymorphisms in the results for homocysteine (Hcy) levels, where heterozygous had higher values.

  3. Among Chinese hypertensive patients without cardiovascular comorbidities, elevated total homocysteine was a significant risk marker for death from all causes, and the association was subject to effect modification by MTHFR genotypes. If confirmed that total homocysteine and MTHFR genotypes may serve as useful biomarkers for mortality risk assessment and targeted intervention

  4. C677T MTHFR gene polymorphism is associated with rheumatoid arthritis (RA) in Egyptians. MTHFR 677TT carriers had higher concentrations of serum homocysteine than did subjects harboring the CC and CT genotypes; presence of 677T allele increases the risk of atherosclerosis in patients with RA, probably due to hyperhomocysteinemia.

  5. The study suggests that the MTHFR C677T and A1298C polymorphisms may have contributed to the risk of polycystic ovary syndrome in the Chinese women investigated

  6. Authors determined whether a polymorphism at the miR (show MLXIP Proteins)-214 binding site in the 3'-untranslated region (3'-UTR) of the methylenetetrahydrofolate reductase gene (MTHFR) is associated with susceptibility to esophageal squamous cell carcinoma (ESCC). Data demonstrate that a polymorphism at the miR (show MLXIP Proteins)-214 binding site in the 3'-UTR of MTHFR is an ESCC susceptibility SNP in the Chinese population.

  7. both tHcy and the MTHFR C677T gene polymorphism may be important determinants of the incidence of dyslipidemia in Chinese patients with essential hypertension

  8. MDR1 rs1045642 and MTHFR rs1801133 should be considered as diagnostic candidates for the identification of pediatric patients with a high risk of suffering adverse events during Acute Lymphoblastic Leukemia treatment.

  9. meta-analysis: evaluated associations between methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and acute lymphoblastic leukaemia using a more comprehensive updated meta-analysis

  10. Results identified MTHFR variant in a large family with an unknown equinus deformity that is different from variants associated with clubfoot. Bioinformatic analysis showed that this mutation could alter the protein binding region.

MTHFR Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Gene names and symbols associated with MTHFR

  • methylenetetrahydrofolate reductase (NAD(P)H) (mthfr)
  • methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR)
  • methylenetetrahydrofolate reductase (metF)
  • methylenetetrahydrofolate reductase (DDB_G0279137)
  • 5,10-methylenetetrahydrofolate reductase (Mthfr)
  • methylenetetrahydrofolate reductase (NAD(P)H) (Mthfr)
  • AI323986 protein
  • DDBDRAFT_0204686 protein
  • DDBDRAFT_0230137 protein
  • DDB_0204686 protein
  • DDB_0230137 protein

Protein level used designations for MTHFR

5,10-methylenetetrahydrofolate reductase , 5,10-methylenetetrahydrofolate reductase (NADPH) , methylenetetrahydrofolate reductase (NAD(P)H) , methylenetetrahydrofolate reductase-like , methylenetetrahydrofolate reductase

GENE ID SPECIES
379784 Xenopus laevis
469800 Pan troglodytes
100125082 Xenopus (Silurana) tropicalis
100391000 Callithrix jacchus
1209960 Coxiella burnetii RSA 493
8621890 Dictyostelium discoideum AX4
17769 Mus musculus
4524 Homo sapiens
362657 Rattus norvegicus
478230 Canis lupus familiaris
397180 Sus scrofa
497032 Bos taurus
419489 Gallus gallus
100715703 Cavia porcellus
Selected quality suppliers for MTHFR Proteins (MTHFR)
Did you look for something else?