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Midline 1 Proteins (MID1)

The protein encoded by MID1 is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. Additionally we are shipping MID1 Antibodies (57) and MID1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MID1 17318 O70583
MID1 4281 O15344
MID1 54252 P82458
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Top MID1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Mouse His tag   1 mg Log in to see 56 to 66 Days
$2,200.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,936.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

MID1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus)

More Proteins for Midline 1 (MID1) Interaction Partners

Mouse (Murine) Midline 1 (MID1) interaction partners

  1. we show that MID1 controls exocytosis of lytic granules and cytotoxicity in murine cytotoxic lymphocytes

  2. X-linked microtubule-associated protein (show SPAG5 Proteins), Mid1, regulates axon development.

  3. MID1 inhibition also limited rhinovirus-induced exacerbation of allergic airway disease

  4. Thus, lack of Mid1 causes a misspecification of the midbrain/cerebellar boundary that results in an abnormal development of the most anterior cerebellar lobes.

  5. Analysis of Mid1, Hccs (show HCCS Proteins), Arhgap6 (show ARHGAP6 Proteins), and Msl3l1 (show MSL3 Proteins) in X-linked polydactyly (Xpl) and Patchy-fur (Paf (show KIAA0101 Proteins)) mutant mice

Human Midline 1 (MID1) interaction partners

  1. A130T/V mutations within the MID1 zinc-binding Bbox1 (show BBOX1 Proteins) domain affects protein folding.

  2. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 (show BBOX1 Proteins) domain disrupt polyubiquitination of alpha4 but not of PP2Ac (show PPP2CA Proteins) in X-linked Opitz syndrome.

  3. TRAIL regulates MID1 and TSLP (show TSLP Proteins), inflammation, fibrosis, smooth muscle hypertrophy, and expression of inflammatory effector chemokines and cytokines in experimental eosinophilic esophagitis.

  4. These studies provide insight into the mechanism by which mutations observed in X-linked Opitz G syndrome affect the structure and function of the MID1 Bbox1 (show BBOX1 Proteins) domain

  5. A familial c.1102C>T (p.R368X) mutation in the MID1 gene, is reported.

  6. Results revealed S422 as a novel phosphorylation site of Osx and GSK-3b played an important role in regulating the protein stability and transactivational activity of Osx.

  7. Fu ubiquitination and cleavage is one of the key elements connecting the MID1-PP2A (show PPP2R4 Proteins) protein complex with GLI3 (show GLI3 Proteins) activity control

  8. Promotion of AR, in addition to enhancement of the Akt (show AKT1 Proteins)-, NFkappaB (show NFKB1 Proteins)-, and Hh-pathways by sustained MID1-upregulation during androgen deprivation therapy provides a powerful proliferative scenario for PCa (show FLVCR1 Proteins) progression into castration resistance

  9. In prostate cancer cells the inhibitory effect of metformin was mimicked by disruption of MID1 translational regulator complex.

  10. Two patients with underdeveloped arcuate fasciculus had novel, nonsynonymous variants in MID1 and EN2 (show EN2 Proteins) genes regulating axon guidance pathway.

MID1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing\; however, the full-length nature of some of the variants has not been determined.

Gene names and symbols associated with Midline 1 Proteins (MID1)

  • midline 1 (Mid1)
  • midline 1 (Opitz/BBB syndrome) (mid1)
  • midline 1 (Opitz/BBB syndrome) (MID1)
  • midline 1 (Opitz/BBB syndrome) (Mid1)
  • 61B3-R protein
  • BBBG1 protein
  • DXHXS1141 protein
  • FXY protein
  • GBBB1 protein
  • MIDIN protein
  • Midline1 protein
  • OGS1 protein
  • OS protein
  • OSX protein
  • RNF59 protein
  • TRIM18 protein
  • XPRF protein
  • ZNFXY protein

Protein level used designations for Midline 1 Proteins (MID1)

midin , midline-1 , tripartite motif-containing protein 18 , RING finger protein 59 , midline 1 RING finger protein , putative transcription factor XPRF , tripartite motif protein TRIM18 , zinc finger on X and Y, mouse, homolog of , Finger on X and Y (in rat only on X)

GENE ID SPECIES
17318 Mus musculus
100330952 Danio rerio
100463496 Xenopus laevis
373920 Gallus gallus
4281 Homo sapiens
491737 Canis lupus familiaris
534604 Bos taurus
54252 Rattus norvegicus
100524415 Sus scrofa
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