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NK3 Homeobox 1 Proteins (NKX3-1)

NKX3-1 encodes a homeobox-containing transcription factor. Additionally we are shipping NK3 Homeobox 1 Antibodies (186) and NK3 Homeobox 1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NKX3-1 18095 P97436
NKX3-1 4824 Q99801
Rat NKX3-1 NKX3-1 305999  
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Top NK3 Homeobox 1 Proteins at

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

NKX3-1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

Top referenced NK3 Homeobox 1 Proteins

  1. Human NKX3-1 Protein expressed in Escherichia coli (E. coli) - ABIN1098730 : Anderson, McKissic, Logan, Roh, Franco, Wang, Doubinskaia, van der Meer, Hayward, Eischen, Eltoum, Abdulkadir: Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. in The Journal of clinical investigation 2012 (PubMed)
    Show all 2 references for ABIN1098730

More Proteins for NK3 Homeobox 1 (NKX3-1) Interaction Partners

Mouse (Murine) NK3 Homeobox 1 (NKX3-1) interaction partners

  1. study demonstrated that expression of homeobox protein NK-3 homolog A(Nkx3.1) influenced both the timing and magnitude of the DNA damage response in the mouse prostate

  2. Nkx3.1 loss and Tmprss2 (show TMPRSS2 Proteins)-ERG (show ERG Proteins) upregulation do not cooperate to enhance prostate tumorigenesis in vivo.

  3. Id4 regulates NKX3.1, Sox9 and PTEN.

  4. activated canonical Wnt (show WNT2 Proteins) signals and Nkx3.1 function in a positive feedback loop to regulate prostate bud growth and luminal epithelial differentiation.

  5. multiple NKX3.1 binding sites were found in the RAMP1 (show RAMP1 Proteins) locus in human prostate cancer cells and in the normal mouse prostate.

  6. Deletions of Klf5 (show KLF5 Proteins) and Nkx3-1 do not have a additive effect in prostatic carcinogenesis in mouse model.

  7. Transcriptional activation of prostate specific (show KLK3 Proteins) homeobox (show PRRX1 Proteins) gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).

  8. Androgen-dependent transcription of the mouse Nkx3.1 gene is conferred through a noncanonical element within the intron of the gene.

  9. Nkx3.1 has a role in bacterial prostatitis and its progression to inflammation and neoplasia

  10. Data indicated that all cells expressing MYC (show MYC Proteins) in PIN (show DYNLL1 Proteins) lesions showed marked reductions in Nkx3.1, implicating MYC (show MYC Proteins) as a key factor that represses Nkx3.1 in PIN (show DYNLL1 Proteins) lesions.

Human NK3 Homeobox 1 (NKX3-1) interaction partners

  1. With deletion mutation analysis, plasmid construction, EMSA and oligonucleotide decoy technique, two Sp1 (show PSG1 Proteins)-elements which located between +29 to +43 and -60 to -46 of NKX3.1 gene were identified and proven to be functional elements.

  2. The androgen-regulated homeodomain transcription factor NKX3.1 plays roles in early prostate development and functions as a prostate-specific (show KLK3 Proteins) tumor suppressor.

  3. the association between the down-regulation of PTEN and NKX3.1 genes contributed to prostate tumorigenesis.

  4. NKX3.1 and DYRK1B (show DYRK1B Proteins) were shown to interact via the DYRK1B (show DYRK1B Proteins) kinase domain. In vitro kinase assay showed that DYRK1B (show DYRK1B Proteins) phosphorylated NKX3.1 at serine 185, a residue critical for NKX3.1 steady-state turnover.

  5. An NKX3.1 binding site polymorphism in the l-plastin (show LCP1 Proteins) promoter leads to differential gene expression in human prostate cancer

  6. Analysis of prostate cancer tissues showed that the presence of a TMPRSS2 (show TMPRSS2 Proteins)-ERG (show ERG Proteins) rearrangement was highly correlated with lower levels of NKX3.1 expression consistent with the role of NKX3.1 as a suppressor of the pathogenic gene rearrangement.

  7. NKX3.1 expression mediate beta-catenin (show CTNNB1 Proteins) and E-cadherin (show CDH1 Proteins) association and cell migration in prostate cells.

  8. Our results indicate that variation in NKX3.1 expression combined with selenium or vitamin E treatment modifies the risk of prostate cancer.

  9. Id4 regulates NKX3.1, Sox9 and PTEN.

  10. NKX3.1 labelling is limited to estrogen/progesterone/androgen receptor (show AR Proteins)-positive breast carcinomas.

NK3 Homeobox 1 (NKX3-1) Protein Profile

Protein Summary

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.

Gene names and symbols associated with NK3 Homeobox 1 Proteins (NKX3-1)

  • NK3 homeobox 1 (nkx3-1-a)
  • NK3 homeobox 1 (NKX3-1)
  • NK3 homeobox 1 (nkx3-1)
  • NK3 homeobox 1 (LOC100354093)
  • NK-3 transcription factor, locus 1 (Drosophila) (Nkx3-1)
  • NK3 homeobox 1 (Nkx3-1)
  • bagpipe protein
  • BAPX2 protein
  • Bax protein
  • koza protein
  • MGC53041 protein
  • MGC97890 protein
  • Nkx-3.1 protein
  • NKX3 protein
  • nkx3-1 protein
  • NKX3.1 protein
  • NKX3A protein
  • si:ch211-67o1.2 protein
  • Xbagpipe protein
  • Xbap protein

Protein level used designations for NK3 Homeobox 1 Proteins (NKX3-1)

NK3 transcription factor related, locus 1 , NK3 homeobox 1 , Drosophila NK-3 transcription factor, locus 1 , homeobox protein NK-3 homolog A , homeobox protein Nkx-3.1 , NK homeobox, family 3, A , NK3 transcription factor homolog A , NK-3 transcription factor, locus 1

379899 Xenopus laevis
486114 Canis lupus familiaris
555375 Danio rerio
743612 Pan troglodytes
100038192 Xenopus (Silurana) tropicalis
100354093 Oryctolagus cuniculus
18095 Mus musculus
4824 Homo sapiens
305999 Rattus norvegicus
782252 Bos taurus
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