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anti-Neurofilament Triplet M Protein (NEFM) Antibodies

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Additionally we are shipping Neurofilament Triplet M Protein Kits (24) and Neurofilament Triplet M Protein Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NEFM 24588 P12839
NEFM 18040 P08553
NEFM 4741 P07197
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Top anti-Neurofilament Triplet M Protein Antibodies at

Showing 10 out of 214 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Hamster Mouse Un-conjugated IHC (fro), IF, IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
REACT_Bird Mouse Un-conjugated ICC, IF, IHC (p), IHC, WB Culture of adult neural cells grown as described (2). Mature neurons can be identified by their morphology and because they stain strongly with antibodies to NF-L, NF-M and NF-H. The surrounding stellate red cells are stained with rabbit polyclonal Rat facial nucleus before RPCA-a-Int. These are apparently mitotic neuronal progenitor cells and express many other neuronal markers. Rat spinal cord homogenate showing the major intermediate filament proteins of the nervous system (lane 1). The remaining lanes show blots of this material stainted with various antibodies including ABIN152480 (lane 3). 0.05 mL Log in to see 7 to 9 Days
All Species Mouse Un-conjugated IF, IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
Chicken Chicken Un-conjugated IHC (fro), IF, WB 0.1 mL Log in to see 6 to 8 Days
Chicken Mouse Un-conjugated IF, WB 0.1 mL Log in to see 6 to 8 Days
Chicken Chicken Un-conjugated ICC, IF, WB View of mixed neuron/glial cultures stained with ABIN152562 (red). The NF-M protein is assembled into neurofilaments which are found throughout the axons, dendrites and perikarya of these cells. Western Blot: 160kDa Neurofilament Medium Antibody [ABIN152562] - Western blots of homogenates of SH-SY5Y cells, a human neuroblastoma cell line. Lane A shows blotting with ABIN152562, which reveals a strong NF-M band at ~150kDa. Lanes B and C are homogenates of SH-SY5Y cells which were treated with maitotoxin to activate caspase family enzymes (ref. 2). Now a ~100kDa band is seen in addition o the major NF-M band. This corresponds to the C-terminal segment of NF-M which is an in vivo calpain degradation product of human NF-M. 0.25 mL Log in to see 7 to 9 Days
Chicken Mouse Un-conjugated WB Western blot analysis of NF-M. Lysate from rat whole brain was either untreated (lanes 1-3) or treated with alkaline phosphatase (50 µg/ml at 37°C for 30 minutes, lane 4). The lysate was then probed with anti-neurofilament (clone RNF406) at concentrations of 1.0 (lane 1), 0.5 (lanes 2, 4), and 0.25 µg/ml (lane 3). RNF406 is identified as a band of 160 kDa. Alkaline phosphatase treatment caused a significant reduction of the NF-M band. 50 μg Log in to see 5 to 6 Days
Chicken Rabbit Un-conjugated FACS, IF (cc), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat cochlea tissue labeled Anti-NF-M/Neurofilament M Polyclonal Antibody, Unconjugated (ABIN672186) at 1:200, followed by conjugation to the secondary antibody and DAB staining RSC96 cells probed with Rabbit Anti-NF-M Polyclonal Antibody . 100 μL Log in to see 3 to 7 Days
REACT_Bird Rabbit Un-conjugated ICC, IHC (fro), IF, IHC (p), IHC, WB Western blot of whole rat cerebellum homogenate stained with ABIN152479, at dilution of 1:20,000. A prominent band running with an apparent SDS-PAGE molecular weight of ~145kDa corresponds to rodent NF-M. Human, cow and bovine NF-M run a little slower, at about 160kDa. Immunohistochemistry-Frozen: NF-M Antibody [ABIN152479] - IHC-Fr staining of cerebral cortex section from Rat with NF-M antibody (red) at 1:5000 dilution. This immunostaining reveals the perikarya of pyramidal neurons and dendrites as well as axons surrounding the neurons. The green channel shows staining with a monoclonal antibody to beta-adrendergic receptor kinase 1. 0.1 mL Log in to see 7 to 9 Days
Mouse Goat Un-conjugated ELISA, WB Western Blot: NF-M Antibody [NBP1-45213] - (0.03ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days

NEFM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Neurofilament Triplet M Protein Antibodies

  1. Bird (Avian) Polyclonal NEFM Primary Antibody for ICC, IHC (fro) - ABIN152479 : Skaat, Ziv-Polat, Shahar, Margel: Enhancement of the growth and differentiation of nasal olfactory mucosa cells by the conjugation of growth factors to functional nanoparticles. in Bioconjugate chemistry 2011 (PubMed)
    Show all 7 references for ABIN152479

  2. Chicken Polyclonal NEFM Primary Antibody for ICC, IF - ABIN152562 : Portmann-Lanz, Schoeberlein, Portmann, Mohr, Rollini, Sager, Surbek: Turning placenta into brain: placental mesenchymal stem cells differentiate into neurons and oligodendrocytes. in American journal of obstetrics and gynecology 2010 (PubMed)
    Show all 3 references for ABIN152562

  3. Chicken Monoclonal NEFM Primary Antibody for WB - ABIN967356 : Fernyhough, Gallagher, Averill, Priestley, Hounsom, Patel, Tomlinson: Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy. in Diabetes 1999 (PubMed)
    Show all 2 references for ABIN967356

  4. Chicken Polyclonal NEFM Primary Antibody for FACS, IF (cc) - ABIN672186 : Gao, Bai, Xiong, Li, Shan, Huang, Ma, Guan: Isolation and characterization of chicken dermis-derived mesenchymal stem/progenitor cells. in BioMed research international 2013 (PubMed)

  5. Mouse (Murine) Polyclonal NEFM Primary Antibody for ELISA, WB - ABIN4339223 : Levy, Liem, DEustachio, Cowan: Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein. in European journal of biochemistry 1987 (PubMed)

  6. Chicken Monoclonal NEFM Primary Antibody for IF, WB - ABIN371828 : Harris, Ayyub, Shaw: A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. in Journal of neuroscience research 1992 (PubMed)

  7. Bird (Avian) Monoclonal NEFM Primary Antibody for ICC, IF - ABIN152480 : Sikora, Leddy, Gulinello, Walkley: X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities. in Disease models & mechanisms 2016 (PubMed)

  8. All Species Monoclonal NEFM Primary Antibody for IF, IHC (p) - ABIN120651 : Dráberová, Sulimenko, Kukharskyy, Dráber: Monoclonal antibody NF-09 specific for neurofilament protein NF-M. in Folia biologica 2000 (PubMed)

  9. Hamster Monoclonal NEFM Primary Antibody for IHC (fro), IF - ABIN112357 : Bauwens, De Groot, Ramaekers, Veldman, Huizing: Expression of intermediate filament proteins in the adult human vestibular labyrinth. in The Annals of otology, rhinology, and laryngology 1992 (PubMed)

More Antibodies against Neurofilament Triplet M Protein Interaction Partners

Mouse (Murine) Neurofilament Triplet M Protein (NEFM) interaction partners

  1. Gene deletion studies demonstrated for the first time that lack of NFM (show CEBPB Antibodies) leads to changes of D1R (show DRD1 Antibodies)-mediated long-term potentiation and D1R (show DRD1 Antibodies)-mediated behavior

  2. Data conclude that NF-H (show NEFH Antibodies) and NF-M (show CEBPB Antibodies) C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.

  3. Computational modeling predicted that an expanded NF-M C terminus extended farther from the neurofilament core independent of lysine-serine-proline (KSP) phosphorylation.

  4. results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H (show NEFH Antibodies) and NF-M (show CEBPB Antibodies)

  5. Data show that the tail domain of neurofilament subunit NF-M (show CEBPB Antibodies), with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons.

  6. results demonstrate NF-M (show CEBPB Antibodies) tail-mediated interactions of neurofilaments, independent of NF transport rate, are critical determinants of the size and cytoskeletal architecture of axons and are mediated in part by the highly phosphorylated tail domain of NF-M (show CEBPB Antibodies)

  7. NF-M regulates the association of NFs with kinesin.

  8. Alpha-internexin (show INA Antibodies) coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M (show CEBPB Antibodies) alone or together with NF-H (show NEFH Antibodies) in mice reduces alpha-internexin (show INA Antibodies) transport & content in axons throughout the CNS.

  9. data indicate that a blockade of NMDA receptors during development of cortical neurons increases the phosphorylation state and the solubility of NF-M (show CEBPB Antibodies), thereby favoring neurite outgrowth

  10. Phosphorylation of NF-M (show CEBPB Antibodies) lysine-serine-proline (KSP) repeats is not an essential component for the acquisition of normal axonal caliber mediated by myelin-dependent outside-in signaling.

Human Neurofilament Triplet M Protein (NEFM) interaction partners

  1. direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease

  2. the importance of alpha-internexin (show INA Antibodies) and NF-L (show NEFL Antibodies) in regulating the conformations of NF-M and NF-H (show NEFH Antibodies)

  3. To study if the increase of levels of neurofilament (NF)-M and NF-L (show NEFL Antibodies) in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L (show NEFL Antibodies).

  4. Two polymorphisms of neurofilament M(Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients.

  5. O-glycosylation of NF-M is highly dynamic and closely interwoven with phosphorylation cascades and may have a pathophysiological role.

  6. variation in NEF3 influence rate of response to typical antipsychotic medication

Neurofilament Triplet M Protein (NEFM) Antigen Profile

Protein Summary

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with NEFM

  • neurofilament, medium polypeptide (NEFM) antibody
  • neurofilament triplet M protein (TVAG_582010) antibody
  • neurofilament triplet M protein (TVAG_379630) antibody
  • CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) antibody
  • neurofilament medium polypeptide-like (LOC100852255) antibody
  • neurofilament medium polypeptide-like (LOC100625407) antibody
  • neurofilament, medium polypeptide (Nefm) antibody
  • neurofilament, medium polypeptide (nefm-a) antibody
  • nef-m antibody
  • nef3 antibody
  • nefm antibody
  • nf-m antibody
  • NF160 antibody
  • NF165 antibody
  • NFM antibody

Protein level used designations for NEFM

neurofilament protein M , neurofilament, medium polypeptide 150kDa , neurofilament triplet M protein , CCAAT box/enhancer binding protein beta , CCAAT/enhancer-binding protein beta , CCR protein , c/EBP beta , transcription factor NF-M , 160 kDa neurofilament protein , major neuronal intermediate filament subunit , neurofilament 3 , neurofilament M subunit , neurofilament medium polypeptide , NF-M , Neurofilament protein, middle polypeptide , neurofilament 3, medium , neurofilament-M , neurofilament-3 (150 kD medium) , NF-M c-terminus , NF-M protein , neurofilament 3 (150kDa medium) , middle molecular weight neurofilament protein NF-M(1)

787355 Oryctolagus cuniculus
4736859 Trichomonas vaginalis G3
4769334 Trichomonas vaginalis G3
396185 Gallus gallus
100852255 Bos taurus
100625407 Sus scrofa
281347 Bos taurus
24588 Rattus norvegicus
18040 Mus musculus
4741 Homo sapiens
396206 Gallus gallus
100009343 Oryctolagus cuniculus
397994 Xenopus laevis
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