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Nicotinamide Nucleotide Transhydrogenase (NNT) ELISA Kits

NNT encodes an integral protein of the inner mitochondrial membrane. Additionally we are shipping NNT Antibodies (46) and NNT Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human NNT NNT 23530 Q13423
NNT 18115  
Anti-Rat NNT NNT 310378  
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 7.81 pg/mL 2000-31.25 pg/mL Typical standard curve 96 Tests Log in to see 11 to 13 Days

More ELISA Kits for NNT Interaction Partners

Caenorhabditis elegans (C. elegans) Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. nnt-1 is important in the defense against mitochondrial oxidative stress

Human Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. NNT should be sequenced in all primary adrenal insufficiencies for which the most frequent etiologies have been ruled out. As NNT is involved in oxidative stress, careful follow-up is needed to evaluate mineralocorticoid biosynthesis extent, and gonadal, heart and thyroid function.

  2. identified a 6.67 Mb homozygous region harboring the NNT gene in a Dutch patient presenting with familial glucocorticoid deficiency (FGD (show FGD1 ELISA Kits)); a novel homozygous mutation (NM_012343.3: c.1259dupG) in NNT was revealed; reviewed the literature for all the reported NNT mutations and their clinical presentation

  3. This report of a novel NNT mutation, p.G200S, expands the phenotype of NNT mutations to include mineralocorticoid deficiency. It provides the first evidence that NNT mutations can cause oxidative stress and mitochondrial defects.

  4. Data suggest mutations in nicotinamide nucleotide transhydrogenase (NNT) as contributory to left ventricular noncompaction (LVNC).

  5. NNT mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin (show INS ELISA Kits).

  6. Results suggest that NNT may have a role in ROS (show ROS1 ELISA Kits) detoxification in human adrenal glands.

  7. In the failing heart a partial loss of Nnt activity adversely impacts NADPH (show NQO1 ELISA Kits)-dependent enzymes and the capacity to maintain membrane potential, thus contributing to a decline in bioenergetic capacity, redox regulation and antioxidant defense.

Mouse (Murine) Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. Pathologic workload reverses Nnt to deplete NADPH (show FDXR ELISA Kits) and antioxidative capacity. Reverse Nnt induces mitochondrial oxidative stress and necrosis.

  2. In mitochondria, genetic or pharmacological disruptions in the PDHC-NNT redox circuit negate counterbalance changes in energy expenditure

  3. Data conclude that Herpud1 (show HERPUD1 ELISA Kits) regulates insulin (show INS ELISA Kits) secretion via control of Nnt expression.

  4. our data suggest that NNT functions as a high-capacity source of mitochondrial NADPH (show FDXR ELISA Kits) and that its functional loss due to the Nnt mutation results in mitochondrial redox abnormalities

  5. the role of NNT in regulating central carbon metabolism via redox balance, calling for other mechanisms that coordinate substrate preference to maintain a functional TCA cycle.

  6. Our results demonstrate a novel role for NNT as a regulator of macrophage-mediated inflammatory responses

  7. A normal Nnt allele can help with better cardiac function in MnSOD (show SOD2 ELISA Kits)-deficient mice during fetal development.

  8. The presence of a truncated Nnt did not affect insulin (show INS ELISA Kits) secretion or glucose tolerance on the C57BL/6 background.

  9. Nnt was identified as a novel candidate gene for contribution to glucose intolerance through reduced beta cell activity.

  10. Mutations/deletion uncouple pancreatic beta cell mitochondrial metabolism leading to less ATP production, enhanced KATP channel activity, and consequently impaired insulin (show INS ELISA Kits) secretion.

NNT Antigen Profile

Antigen Summary

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.

Gene names and symbols associated with NNT

  • Nicotinamide Nucleotide Transhydrogenase (nnt-1) antibody
  • nicotinamide nucleotide transhydrogenase (AFUA_5G02780) antibody
  • nicotinamide nucleotide transhydrogenase (nnt) antibody
  • nicotinamide nucleotide transhydrogenase (NNT) antibody
  • nicotinamide nucleotide transhydrogenase (Nnt) antibody
  • 4930423F13Rik antibody
  • Afu5g02780 antibody
  • AI323702 antibody
  • BB168308 antibody
  • GCCD4 antibody
  • wu:fa20d10 antibody
  • wu:fc86a04 antibody
  • zgc:76979 antibody

Protein level used designations for NNT

Nicotinamide Nucleotide Transhydrogenase family member (nnt-1) , nicotinamide nucleotide transhydrogenase , NAD(P) transhydrogenase, mitochondrial , pyridine nucleotide transhydrogenase , Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)

180884 Caenorhabditis elegans
3505502 Aspergillus fumigatus Af293
100158572 Xenopus (Silurana) tropicalis
23530 Homo sapiens
18115 Mus musculus
310378 Rattus norvegicus
406619 Danio rerio
447528 Xenopus laevis
427196 Gallus gallus
280878 Bos taurus
479342 Canis lupus familiaris
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