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NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. Additionally we are shipping NONO Antibodies (96) and NONO Proteins (8) and many more products for this protein.
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p54(nrb) is a novel regulator of SREBP-1a in the nucleus, and the data suggest that p54(nrb) regulation of SREBP-1a supports the increased cellular demand of lipids for breast cancer growth.
Data uncover a new role for NONO in mediating the cellular response to UV-induced DNA damage.
p54nrb and hnRNPM knockdown silences the FGF1 promoter-dependent accumulation of mRNA during myoblast differentiation.
Subnuclear re-localization of SOX10 (show SOX10 ELISA Kits) and p54NRB correlates with a unique neurological phenotype associated with SOX10 (show SOX10 ELISA Kits) missense mutations
These data suggest that NonO negatively regulates HIV-1 infection in CD4 (show CD4 ELISA Kits)(+) T cells, highlighting the importance of host proteins associated with HIV-1 preintegration complexes in regulating viral replication.
Mutations in NONO led to defects at inhibitory synapses in intellectual disability syndrome.
Patients with aortic dissection (AD)exhibited significantly decreased expression of P54(nrb) /NonO. The significant correlation between P54(nrb) /NonO and collagen may point to novel thinking about collagen metabolism research in AD aorta.
silencing p54(nrb)/NONO expression in H295R human adrenocortical cells decreases the ability of the cells to increase intracellular cAMP production and subsequent cortisol biosynthesis in response to adrenocorticotropin hormone (ACTH (show POMC ELISA Kits)) stimulation.
The ability of the SFPQ/NONO complex to form varying protein assemblies, in conjunction with the effect of post-translational modifications of SFPQ modulating mRNA binding, suggests key roles affecting mRNP dynamics within the cell.
p54 (show DDX6 ELISA Kits) is essential for GC-mediated expression of occludin (show OCLN ELISA Kits), claudin-5 (show CLDN5 ELISA Kits), and barrier induction, and the p54 (show DDX6 ELISA Kits)/PSF (show IGFBP7 ELISA Kits) heterodimer may contribute to normal blood-retinal barrier (BRB (show PTBP1 ELISA Kits)) induction in vivo.
mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets
Cytoplasmic granule containing HERMES (show CD44 ELISA Kits), NonO, PSF (show Il3 ELISA Kits), and G3BP1 (show G3BP1 ELISA Kits) is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
Quantitative proteomics reveals dynamic interaction of JNK (show MAPK8 ELISA Kits) with RNA transport granule proteins Sfpq and Nono during neuronal differentiation
We analyzed the expression of sperm-specific Akap3 (show AKAP3 ELISA Kits) and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.
NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.
Dsta indicate that NONO bound to p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion.
Basal and cyclic AMP (show TMPRSS5 ELISA Kits)-induced Rbp4 (show RBP4 ELISA Kits) transcription is regulated by a multiprotein complex that is similar to ones that modulate expression of genes of steroid hormone biosynthesis.
p54nrb is a target of the peptidylprolyl isomerase (show PPI ELISA Kits) Pin1 (show PIN1 ELISA Kits), suggesting that it may be regulated by phosphorylation-dependent conformational changes as many other nuclear proteins upon entry into mitosis
identified two proteins, NONO and WDR5 (show WDR5 ELISA Kits), that can associate with the mammalian PER1 (show PER1 ELISA Kits) protein; data suggest that NONO probably operates antagonistically to PER proteins in mammalian cells, and that it is essential to normal circadian rhythmicity
PSPC1 (show PSPC1 ELISA Kits), NONO, and SFPQ form complexes with each other in Sertoli cells and may regulate androgen receptor (show AR ELISA Kits)-mediated transcriptional activity
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.
54 kDa nuclear RNA- and DNA-binding protein
, 55 kDa nuclear protein
, DNA-binding p52/p100 complex, 52 kDa subunit
, non-POU domain-containing octamer (ATGCAAAT) binding protein
, non-POU domain-containing octamer-binding protein
, non-POU-domain-containing, octamer-binding protein
, 54 kD nuclear RNA-binding protein