Non-POU Domain Containing, Octamer-Binding Proteins (NONO)

NONO encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. Additionally we are shipping NONO Antibodies (119) and NONO Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NONO 4841 Q15233
NONO 317259 Q5FVM4
NONO 53610 Q99K48
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Top NONO Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days

NONO Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus) ,

Mouse (Murine)

More Proteins for Non-POU Domain Containing, Octamer-Binding (NONO) Interaction Partners

Human Non-POU Domain Containing, Octamer-Binding (NONO) interaction partners

  1. Exome analysis identified a novel de novo splice-site variant c.1171+1G>T in exon 11 of NONO gene in a patient with intellectual disability and non-compaction cardiomyopathy.

  2. Case Report: melanotic PEComa of the sinonasal mucosa with NONO-TFE3 (show TFE3 Proteins) fusion.

  3. High expression of P54 (show DDX6 Proteins) is associated with breast cancer.

  4. The present study indicates that p54nrb is a powerful molecule involved in the regulation of cell motility and promotes the migration and invasion of THP1 cells, and it is more likely to be involved in the release of inflammatory mediators and the motility of inflammatory cells.

  5. p54(nrb) is a novel regulator of SREBP-1a in the nucleus, and the data suggest that p54(nrb) regulation of SREBP-1a supports the increased cellular demand of lipids for breast cancer growth.

  6. Data uncover a new role for NONO in mediating the cellular response to UV-induced DNA damage.

  7. p54nrb and hnRNPM knockdown silences the FGF1 promoter-dependent accumulation of mRNA during myoblast differentiation.

  8. Subnuclear re-localization of SOX10 (show SOX10 Proteins) and p54NRB correlates with a unique neurological phenotype associated with SOX10 (show SOX10 Proteins) missense mutations

  9. These data suggest that NonO negatively regulates HIV-1 infection in CD4 (show CD4 Proteins)(+) T cells, highlighting the importance of host proteins associated with HIV-1 preintegration complexes in regulating viral replication.

  10. Mutations in NONO led to defects at inhibitory synapses in intellectual disability syndrome.

Mouse (Murine) Non-POU Domain Containing, Octamer-Binding (NONO) interaction partners

  1. NONO deficiency significantly compromises the response to ionizing radiation-induced DNA damage in the testes, consistent with cell type-specific loss of DSB repair capacity. The results provide evidence that this RNA binding protein significantly contributes to the DNA damage response in vivo.

  2. Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1 (show PSPC1 Proteins))-aldehyde dehydrogenase 1 (NONO/PSPC1 (show PSPC1 Proteins)-ALDH1A1 (show ALDH1A1 Proteins)) in the modulation of Sertoli cells (SCs (show TWIST1 Proteins)) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.

  3. This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 (show RRM1 Proteins) to one of its target RNAs.

  4. mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets

  5. Cytoplasmic granule containing HERMES (show CD44 Proteins), NonO, PSF (show IL-3 Proteins), and G3BP1 (show G3BP1 Proteins) is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.

  6. Quantitative proteomics reveals dynamic interaction of JNK (show MAPK8 Proteins) with RNA transport granule proteins Sfpq and Nono during neuronal differentiation

  7. We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  8. NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.

  9. Dsta indicate that NONO bound to p16-Ink4A cell cycle checkpoint gene and potentiated its circadian activation in a PER protein-dependent fashion.

  10. Basal and cyclic AMP (show TMPRSS5 Proteins)-induced Rbp4 (show RBP4 Proteins) transcription is regulated by a multiprotein complex that is similar to ones that modulate expression of genes of steroid hormone biosynthesis.

NONO Protein Profile

Protein Summary

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.

Gene names and symbols associated with NONO

  • non-POU domain containing, octamer-binding (NONO)
  • non-POU domain containing, octamer-binding (Nono)
  • non-POU domain containing, octamer-binding (nono)
  • non-POU-domain-containing, octamer binding protein (Nono)
  • AA407051 protein
  • AV149256 protein
  • nmt55 protein
  • nonA protein
  • nrb54 protein
  • P54 protein
  • p54nrb protein
  • xp54nrb protein

Protein level used designations for NONO

54 kDa nuclear RNA- and DNA-binding protein , 55 kDa nuclear protein , DNA-binding p52/p100 complex, 52 kDa subunit , non-POU domain-containing octamer (ATGCAAAT) binding protein , non-POU domain-containing octamer-binding protein , p54(nrb) , non-POU-domain-containing, octamer-binding protein , 54 kD nuclear RNA-binding protein

4841 Homo sapiens
428701 Gallus gallus
612773 Canis lupus familiaris
615175 Bos taurus
317259 Rattus norvegicus
380427 Xenopus laevis
53610 Mus musculus
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