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anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) Antibodies

OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. Additionally we are shipping OPA1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OPA1 74143 P58281
OPA1 171116 Q2TA68
OPA1 4976 O60313
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Top anti-OPA1 Antibodies at

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, IHC (p), SimWes, WB Staining in prostatic smooth muscle and glandular epithelium using ABIN258401. Human Prostate 40X magnification. Detection of Opa-1 protein using ABIN258401 in post-nuclear extracts of mouse embryonic fibroblasts. 0.1 mL Log in to see 7 to 9 Days
Chicken Mouse Un-conjugated IF, WB Western blot analysis of OPA1 on a K-562 cell lysate (Human bone marrow myelogenous leukemia, ATCC CCL-243). Lane 1: 1:500, lane 2: 1000, lane 3: 1: 2000 dilution of the mouse anti- OPA1 antibody. Immunofluorescence staining of COS-7 cells (African Green Monkey SV40 transformed kidney cells, ATCC CRL-1651). 50 μg Log in to see 5 to 6 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti OPA1 Polyclonal Antibody, Unconjugated (ABIN1387244) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
Chinese Hamster Mouse Un-conjugated ICC, IF, IHC, IHC (p), SimWes, WB Simple Western: OPA1 Antibody (1E8-1D9) [NBP1-71656] - Simple Western lane view shows a specific band for OPA1 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Immunocytochemistry/Immunofluorescence: OPA1 Antibody (1E8-1D9) [NBP1-71656] - OPA1 antibody was tested in ARPE-19 cells with FITC (green). Nuclei and actin were counterstained with Dapi (blue) and Phalloidin (red). 0.1 mL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated IHC (p), WB Anti- OPA1 Picoband antibody, IHC(P) IHC(P): Rat Kidney Tissue Anti- OPA1 Picoband antibody, IHC(P) IHC(P): Mouse Liver Tissue 100 μg Log in to see 4 to 6 Days
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated WB Western blot analysis of OPA1 expression in A549 (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using OPA1 antibody. 100 μL Log in to see 14 Days
Human Mouse Un-conjugated ELISA   50 μL Log in to see 9 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry: OPA1 Antibody [NBP2-34206] - Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts. Western Blot: OPA1 Antibody [NBP2-34206] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4 0.1 mL Log in to see 8 to 11 Days

OPA1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-OPA1 Antibodies

  1. Chicken Polyclonal OPA1 Primary Antibody for IHC, IHC (p) - ABIN258401 : Dai, Hsieh, Liu, Chen, Beyer, Chin, MacCoss, Rabinovitch: Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. in Cardiovascular research 2011 (PubMed)
    Show all 13 references for ABIN258401

  2. Chicken Monoclonal OPA1 Primary Antibody for IF, WB - ABIN968891 : Alexander, Votruba, Pesch, Thiselton, Mayer, Moore, Rodriguez, Kellner, Leo-Kottler, Auburger, Bhattacharya, Wissinger: OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28. in Nature genetics 2000 (PubMed)
    Show all 3 references for ABIN968891

  3. Chinese Hamster Monoclonal OPA1 Primary Antibody for ICC, IF - ABIN4341456 : Montaigne, Marechal, Coisne, Debry, Modine, Fayad, Potelle, El Arid, Mouton, Sebti, Duez, Preau, Remy-Jouet, Zerimech, Koussa, Richard, Neviere, Edme, Lefebvre, Staels: Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients. in Circulation 2014 (PubMed)
    Show all 2 references for ABIN4341456

  4. Human Polyclonal OPA1 Primary Antibody for ELISA - ABIN562069 : Yarosh, Monserrate, Tong, Tse, Le, Nguyen, Brachmann, Wallace, Huang: The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment. in PLoS genetics 2008 (PubMed)

  5. Human Polyclonal OPA1 Primary Antibody for IF (p), IHC (p) - ABIN1387244 : Ku, Ji, Zhang, Li, Sang: PM2.5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain. in Chemosphere 2016 (PubMed)

More Antibodies against OPA1 Interaction Partners

Mouse (Murine) Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. OPA1 (show MED12 Antibodies) modulates cristae morphology but is dispensable for cristae junction formation. Endogenous OPA1 (show MED12 Antibodies) and MIC60 show a physical interaction.

  2. Opa1 (show MED12 Antibodies) deficiency was associated with increased sensitivity to Ischemia-Reperfusion Injuries, imbalance in dynamic mitochondrial Ca2 (show CA2 Antibodies)+ uptake, and subsequent increase in NCX (show SLC8A1 Antibodies) activity.

  3. Whereas Parkin (show PARK2 Antibodies) has been reported to positively regulate the expression of OPA1 (show MED12 Antibodies) through NEMO (show IKBKG Antibodies), herein we found that PARK2 (show PARK2 Antibodies) overexpression did not modify the expression of OPA1 (show MED12 Antibodies).

  4. stress-induced OMA1 (show OMA1 Antibodies) activation and guanosine triphosphatase OPA1 (show MED12 Antibodies) cleavage limit mitochondrial fusion and promote neuronal death

  5. Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 (show MED12 Antibodies) and Yme1L (show YME1L1 Antibodies), are altered; in vitro and in vivo, OPA1 (show MED12 Antibodies) is cleaved to shorter forms and Yme1L (show YME1L1 Antibodies) expression is reduced.

  6. results indicate that the OPA1 (show MED12 Antibodies)-dependent cristae remodeling pathway is a fundamental, targetable determinant of tissue damage in vivo.

  7. cristae shape amelioration by controlled Opa1 (show MED12 Antibodies) overexpression improves two mouse models of mitochondrial disease.

  8. unprocessed OPA1 (show MED12 Antibodies) is sufficient to maintain heart function, OMA1 (show OMA1 Antibodies) is a critical regulator of cardiomyocyte survival, and mitochondrial morphology and cardiac metabolism are intimately linked.

  9. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: OPA1 (show MED12 Antibodies), Drp1 (dynamin 1-like protein (show DNM1L Antibodies)), and Mfn1 (show MFN1 Antibodies)/2 (mitofusin 1 (show MFN1 Antibodies) and 2). [REVIEW]

  10. Photoresponsive RGCs are protected against cell death due to the Opa1 (show MED12 Antibodies) mutation, but not by melanopsin (show OPN4 Antibodies) expression itself.

Human Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. The present study identified novel compound heterozygous OPA1 mutations in a patient with recessive optic atrophy, sensorimotor neuropathy and congenital cataracts, indicating an expansion of the clinical spectrum of pathologies associated with OPA1 mutations.

  2. Optic atrophy type 1, caused by mutations in the OPA1 gene is believed to be the most common hereditary optic neuropathy, and most patients inherit a mutation from an affected parent. In this study we used whole-exome sequencing to investigate the genetic aetiology in a patient affected with isolated optic atrophy. Exome results identified a novel de novo OPA1 mutation.

  3. Findings show a new mode of regulation of the mitochondrial fusion proteins, Mfns degradation or OPA1 processing, in response to mitochondrial morphology.

  4. Loss of OPA1 protein function by pathogenic OPA1 gene mutation induces increased mitochondrial fragmentation that promotes instability of the mitochondrial respiratory chain complexes.

  5. Two heterozygous mutations, p.T414P (c.1240A>C) and p.T540P (c.1618A>C), located in the GTPase (show RACGAP1 Antibodies) and middle domains of OPA1, respectively, were identified in two patients.These two different conformational changes might result in decreased GTPase (show RACGAP1 Antibodies) activities that trigger autosomal dominant optic atrophy associated with auditory neuropathy spectrum disorder

  6. A causal link between a pathogenic homozygous OPA1 mutation and hypertrophic cardiomyopathy with optic atrophy was established.It emphasise the vital role played by OPA1 in mitochondrial biogenesis and mtDNA maintenance.

  7. OPA1 variants confer risk of leprosy in Chinese Han population and may affect OPA1 expression, mitochondrial function and antimicrobial pathways.

  8. Genotype-phenotype heterogeneity in OPA1 autosomal-dominant optic atrophy (ADOA). is evident when inner retinal atrophy is examined as a function of age.

  9. Heterozygous mutation in OPA1 disrupts the GTPase (show RACGAP1 Antibodies) domain of OPA1 and is associated with phenotypically variable ADOA Plus.

  10. Identification of copy number variation in the gene for autosomal dominant optic atrophy, OPA1, in a Chinese pedigree

Zebrafish Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. Opa1 is required for proper mitochondrial metabolism in early development

OPA1 Antigen Profile

Protein Summary

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with OPA1

  • optic atrophy 1 (Opa1) antibody
  • optic atrophy 1 (autosomal dominant) (OPA1) antibody
  • optic atrophy 1 (human) (opa1) antibody
  • 1200011N24Rik antibody
  • AI225888 antibody
  • AI847218 antibody
  • fk62d06 antibody
  • largeG antibody
  • lilr3 antibody
  • MGM1 antibody
  • mKIAA0567 antibody
  • NPG antibody
  • NTG antibody
  • wu:fb77a10 antibody
  • wu:fk62d06 antibody
  • zgc:92092 antibody

Protein level used designations for OPA1

dynamin-like 120 kDa protein, mitochondrial , large GTP-binding protein , largeG , optic atrophy 1 homolog , optic atrophy protein 1 homolog , RN protein , optic atrophy 1 (autosomal dominant) , optic atrophy 1-like protein , dynamin-like guanosine triphosphatase , mitochondrial dynamin-like GTPase , optic atrophy protein 1

74143 Mus musculus
171116 Rattus norvegicus
4976 Homo sapiens
424900 Gallus gallus
477129 Canis lupus familiaris
524142 Bos taurus
100172619 Pongo abelii
492332 Danio rerio
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