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P450 (Cytochrome) Oxidoreductase Proteins (POR)

POR encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. Additionally we are shipping POR Antibodies (113) and POR Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POR 76932 Q8K221
POR 293344 Q6AY65
POR 5447 P16435
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Top POR Proteins at

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 59 to 64 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 59 to 64 Days
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 11 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days

POR Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Rat (Rattus) ,

Human , , , ,
, ,

More Proteins for P450 (Cytochrome) Oxidoreductase (POR) Interaction Partners

Mouse (Murine) P450 (Cytochrome) Oxidoreductase (POR) interaction partners

  1. Highest level of Rac1 activation was achieved on the smallest nanofibers, a trend that was lost in POR1 knockdown. This supports the hypothesis that on small nanofibers, POR1 binds to highly curved cell membranes, allowing Rac1 to dissociate and activate.

  2. Results are the first to show that some forms of opioid-mediated stress-induced analgesia require brain neuronal P450 activity.

  3. Immunological and metabolic changes resulting from a genetic deficiency in CPR (show GRID2 Proteins) expression in the intestine in mice.

  4. An apparent link exists between the cytochrome p450 reductase and FGF signaling pathways.

  5. These data collectively indicate a novel role of the Cpr (show GRID2 Proteins) gene in fear conditioning and memory.

  6. this study provides novel insights into the regulation of gap junction function by CYPOR and suggests that Cx43 (show GJA1 Proteins) may play an important role(s) in CYPOR-mediated bone defects seen in patients.

  7. inactivation of the hepatic cytochrome P450 system by conditional deletion of this enzyme

  8. Changes in hepatic mRNA expression using microarray analysis and real-time PCR in POR null mice are reported.

  9. POR function is indispensable for the proper regulation of retinoic acid levels and tissue distribution not only during early embryonic development but also in later morphogenesis and molecular patterning of the brain, abdominal/caudal region and limbs.

  10. Data suggest that cellular cytochrome P450 oxidoreductase (show HSD17B6 Proteins)-dependent cholesterol synthesis is essential during limb and skeletal development.

Xenopus laevis P450 (Cytochrome) Oxidoreductase (POR) interaction partners

  1. NADPH-P450 reductase (NPR) was purified from hepatic microsomes of Xenopus laevis.

Human P450 (Cytochrome) Oxidoreductase (POR) interaction partners

  1. POR A503V might decrease the risk of bladder cancer by reducing its metabolic activity.

  2. POR besides CYP2B6 (show CYP2B6 Proteins) can influence cyclophosphamide metabolism

  3. Study is a thorough structural, dynamic, and thermodynamic characterization of the soluble form of human microsomal CPR using small-angle x-ray scattering and nuclear magnetic resonance spectroscopy under various conditions

  4. This study confirmed that CYP3A5 (show CYP3A5 Proteins)*1 was associated with lower tacrolimus trough concentrations. POR*28 was associated with decreased tacrolimus trough concentrations although the effect was small possibly through enhanced CYP3A4 (show CYP3A4 Proteins) enzyme activity.

  5. electron transfer between mCPR and aromatase (show CYP19A1 Proteins)

  6. POR is the main determinant of SN30000 sensitivity in 3 different genetic backgrounds. Head and neck squamous cell carcinomas showed heterogeneous POR expression. There may be a relationship between HPV status and hypoxia-activated prodrug sensitivity.

  7. Results show that combining the CYP3A5 (show CYP3A5 Proteins)*1, POR*28 and CYP3A4 (show CYP3A4 Proteins)*22 genotypes allows partial differentiation of early tacrolimus dose requirements and the time to reach therapeutic target concentrations after transplantation.

  8. In children with FH, carriage of POR*28 allele is associated with reduced effect of atorvastatin on TChol and LDLc and therefore identifies FH children that may require higher atorvastatin doses to achieve full therapeutic benefits

  9. The ABCB1 (show ABCB1 Proteins) was significantly associated with the CDR (show RUNX1T1 Proteins) . CYP3A4 (show CYP3A4 Proteins)*1G and CYP3A5 (show CYP3A5 Proteins)*3 could influence CBZ metabolism, while POR*28 had no effect on it. The EPHX1 (show EPHX1 Proteins) were significantly associated with CBZD:CBZE ratio.

  10. Transient kinetic dissection of the reaction of POR with NADPH (show NQO1 Proteins) and the reduction in cytochrome c (show CYCS Proteins) by POR using stopped-flow techniques revealed defects in individual electron transfer steps mediated by A287P.

POR Protein Profile

Protein Summary

This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome.

Gene names and symbols associated with POR

  • Cytochrome P450 reductase (Cpr)
  • P450 (cytochrome) oxidoreductase (POR)
  • P450 (cytochrome) oxidoreductase (por)
  • ADP-ribosylation factor interacting protein 2 (Arfip2)
  • P450 (cytochrome) oxidoreductase (Por)
  • tubulin-folding cofactor C (POR)
  • 2310002N04Rik protein
  • 4933424M13Rik protein
  • CCR protein
  • CG11567 protein
  • cpr protein
  • CYPOR protein
  • DmCPR protein
  • Dmel\\CG11567 protein
  • DMR protein
  • NCPR protein
  • npr protein
  • P450 protein
  • P450R protein
  • POR protein
  • Por1 protein
  • PORCINO protein
  • T5J17.90 protein
  • T5J17_90 protein
  • TFC C protein
  • xpor protein
  • zgc:110032 protein

Protein level used designations for POR

CG11567-PA , CG11567-PB , CG11567-PC , CG11567-PD , Cpr-PA , Cpr-PB , Cpr-PC , Cpr-PD , NADPH-cytochrome P450 oxidoreductase , P450 reductase , cytochrome P450 reductase , cytochrome c reductase (NADPH) , P450 (cytochrome) oxidoreductase , NADPH--cytochrome P450 reductase-like , ADP-ribosylation factor-interacting protein 2 , Arfaptin 2 , arfaptin-2 , partner of RAC1 , ADP-ribosylation factor interacting protein 2 (arfaptin 2) , partner of Rac1 , CPR , NADPH--cytochrome P450 reductase , P450R , NADPH-P450 reductase , NADPH-dependent cytochrome P450 reductase , NADPH-cytochrome P450 reductase , NADPH-cytochrome P-450 oxidoreductase , NADH cytochrome P450 oxydoreductase

33883 Drosophila melanogaster
463481 Pan troglodytes
715888 Macaca mulatta
100406157 Callithrix jacchus
100486781 Xenopus (Silurana) tropicalis
100587002 Nomascus leucogenys
100619047 Monodelphis domestica
76932 Mus musculus
293344 Rattus norvegicus
532512 Bos taurus
29441 Rattus norvegicus
568202 Danio rerio
379707 Xenopus laevis
417520 Gallus gallus
5447 Homo sapiens
489816 Canis lupus familiaris
100170114 Sus scrofa
18984 Mus musculus
100135602 Cavia porcellus
830151 Arabidopsis thaliana
100301554 Oryctolagus cuniculus
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