PDZ Domain Containing 1 Proteins (PDZK1)

PDZK1 encodes a PDZ domain-containing scaffolding protein. Additionally we are shipping PDZK1 Antibodies (122) and PDZK1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDZK1 5174 Q5T2W1
PDZK1 59020 Q9JIL4
PDZK1 65144 Q9JJ40
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Top PDZK1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days

PDZK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Top referenced PDZK1 Proteins

  1. Human PDZK1 Protein expressed in Wheat germ - ABIN1314614 : Fry, Su, Yiu, Cuthbert, Trachtman, Karet Frankl: Mutation conferring apical-targeting motif on AE1 exchanger causes autosomal dominant distal RTA. in Journal of the American Society of Nephrology : JASN 2012 (PubMed)

More Proteins for PDZ Domain Containing 1 (PDZK1) Interaction Partners

Human PDZ Domain Containing 1 (PDZK1) interaction partners

  1. HNF1alpha (show HNF1A Proteins), which has previously been described as a modulator of several transporters of the renal transportosome, is also a key determinant of PDZK1 transcription.

  2. a PDZK1 single nucleotide polymorphism rs12129861 was found to be significantly associated with gout susceptibility (meta-analysis)

  3. PDZK1 was defined as an independent prognostic factor for both OS and DFS (show FST Proteins). These findings indicated that low level of PDZK1 could predict poor clinical outcome in patients with ccRCC.

  4. Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 (show SLC9A3 Proteins) dysfunction observed in the inflamed intestine.

  5. PARP regulates estradiol-mediated cell growth by controlling the ER/IGF-1R (show IGF1R Proteins)/PDZK1 axis.

  6. PDZK1, negatively regulates 5-HT2AR endocytosis and has no effect upon 5-HT2AR-mediated ERK1/2 phosphorylation.

  7. Described is a structure of D-AKAP2 (show AKAP10 Proteins) in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta (show SUCLA2 Proteins)-strand to PDZK1.

  8. PDZK1 and NHERF1 regulate the transport function of OATP1A2 by modulating protein internalization via a clathrin-dependent pathway and by enhancing protein stability.

  9. Correlation between PDZK1, Cdc37 (show CDC37 Proteins), Akt (show AKT1 Proteins) and breast cancer malignancy: the role of PDZK1 in cell growth through Akt (show AKT1 Proteins) stabilization by increasing and interacting with Cdc37 (show CDC37 Proteins)

  10. IRF3 (show IRF3 Proteins) activation by innate antiviral signaling represses TGF-beta (show TGFB1 Proteins)-induced growth inhibition, gene regulation and epithelial-mesenchymal transition, and the generation of Treg effector lymphocytes from naive CD4 (show CD4 Proteins)(+) lymphocytes.

Mouse (Murine) PDZ Domain Containing 1 (PDZK1) interaction partners

  1. Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 (show SLC9A3 Proteins) dysfunction observed in the inflamed intestine.

  2. PDZK1 has novel SR-BI (show SCARB1 Proteins)-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr (show BCR Proteins)

  3. Data show that interaction of the inducible nitric oxide synthase (iNOS (show NOS2 Proteins)) C-terminus with the PDZ domains of EBP50 (show SLC9A3R1 Proteins) protein or Pdzk1 protein CAP70 resulted greater nitric oxide (NO) synthesis.

  4. PDZK1 regulates intracellular trafficking of Oatp1a1.

  5. PDZK1(NHERF3) is entirely non-raft associated with lipid rafts in brush border membrane fractions of NHE3 (show SLC9A3 Proteins).

  6. NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.

  7. SR-BI (show SCARB1 Proteins) and PDZK1 protein and mRNA expression levels fell rapidly in primary hepatocyte cultures, indicating this system does not adequately mimic hepatocytes in vivo for analysis of the PDZK1 dependence of SR-BI (show SCARB1 Proteins).

  8. the localization of PDZK1 on hepatocyte cell surface membranes in vivo is dependent on its PDZ4 domain and the presence of SR-BI (show SCARB1 Proteins).

  9. The impairment of the absorptive function of the inflamed colon in the IL-10 (show IL10 Proteins)(-/-) mouse, in spite of unaltered NHE3 (show SLC9A3 Proteins) expression and localization, is accompanied by the downregulation of the NHE3 (show SLC9A3 Proteins)-regulatory PDZ adaptors NHERF2 (show SLC9A3R2 Proteins) and PDZK1.

  10. PDZK1 plays a pivotal role in the apical localization of BCRP.

PDZK1 Protein Profile

Protein Summary

This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PDZK1

  • PDZ domain containing 1 (PDZK1)
  • PDZ domain containing 1 (pdzk1)
  • PDZ domain containing 1 (Pdzk1)
  • 1700023D20Rik protein
  • 2610507N21Rik protein
  • 4921513F16Rik protein
  • AI267131 protein
  • AI314638 protein
  • AL022680 protein
  • CAP70 protein
  • Clamp protein
  • D3Ertd537e protein
  • mPDZK1 protein
  • NHERF-3 protein
  • NHERF3 protein
  • Pdzd1 protein
  • PDZK1 protein
  • xpdzk1 protein

Protein level used designations for PDZK1

PDZ domain containing 1 , Na(+)/H(+) exchange regulatory cofactor NHE-RF3-like , CFTR-associated protein of 70 kDa , Na(+)/H(+) exchange regulatory cofactor NHE-RF3 , PDZ-containing kidney protein 1 , na/Pi cotransporter C-terminal-associated protein 1 , naPi-Cap1 , sodium-hydrogen exchanger regulatory factor 3 , NHERF-3 , Na(+)/H(+) exchanger regulatory factor 3 , PDZ domain-containing protein 1 , PDZK1-like protein , C-terminal linking and modulating protein , C-terminal-linking and modulating protein , dietary Pi-regulated RNA-1 , diphor-1

418460 Gallus gallus
446272 Xenopus laevis
696698 Macaca mulatta
100065636 Equus caballus
100145801 Xenopus (Silurana) tropicalis
100152549 Sus scrofa
100403156 Callithrix jacchus
100482698 Ailuropoda melanoleuca
100012609 Monodelphis domestica
100588075 Nomascus leucogenys
100611671 Pan troglodytes
5174 Homo sapiens
59020 Mus musculus
475823 Canis lupus familiaris
534439 Bos taurus
100008900 Oryctolagus cuniculus
65144 Rattus norvegicus
100173285 Pongo abelii
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