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POU Class 5 Homeobox 1 Proteins (POU5F1)

POU5F1 encodes a transcription factor containing a POU homeodomain. Additionally we are shipping OCT4 Antibodies (402) and OCT4 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POU5F1 5460 Q01860
Rat POU5F1 POU5F1 294562  
POU5F1 18999 P20263
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Top OCT4 Proteins at

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human TAT tag   2 μg Log in to see 6 to 11 Days

POU5F1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Top referenced OCT4 Proteins

  1. Human OCT4 Protein expressed in Escherichia coli (E. coli) - ABIN1098764 : Takahashi, Tanabe, Ohnuki, Narita, Ichisaka, Tomoda, Yamanaka: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. in Cell 2007 (PubMed)
    Show all 2 references for ABIN1098764

More Proteins for POU Class 5 Homeobox 1 (POU5F1) Interaction Partners

Human POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. the pathogenesis of human hepatocellular carcinoma may be mediated by OCT4.

  2. OCT4 plays a role as a transcriptional activator for GDF3 (show GDF3 Proteins) transcription in pluripotent human embryonic carcinoma NCCIT cells and contributes to the understanding of the molecular networks of stem cell regulators in germ cell-derived pluripotency and tumorigenesis.

  3. renal cell carcinoma (show MOK Proteins) patients with low Nanog (show NANOG Proteins) and Oct4 expressions in tumor tissues had significantly higher survival rates (p < 0.05). High Nanog (show NANOG Proteins) and Oct4 expressions may be potential therapeutic targets.

  4. Data indicate that cells cultured on cardiac muscle laminin (LN)-based substrata in combination with stimulation of the canonical Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway showed increased gene expression of ISL1 (show ISL1 Proteins), OCT4, KDR (show KDR Proteins) and NKX2.5 (show NKX2-5 Proteins).

  5. we show that the two PAX6 (show PAX6 Proteins) isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12 (show KRT12 Proteins)). PAX6 (show PAX6 Proteins) isoform-a induced KRT3 expression by targeting its upstream region. KLF4 (show KLF4 Proteins) enhanced this induction. A combination of PAX6 (show PAX6 Proteins) isoform-b, KLF4 (show KLF4 Proteins), and OCT4 induced KRT12 (show KRT12 Proteins) expression

  6. POU5F1/Oct-4 expression levels are significantly associated with non-SLN metastases.

  7. Findings reveal that miR (show MLXIP Proteins)-302 regulates OCT4 by suppressing AKT1 (show AKT1 Proteins), which provides hPSCs two characteristics related to their potential for clinical applications: the benefit of pluripotency and the hindrance of teratoma (show DND1 Proteins) formation.

  8. The relative expression of OCT-4 is upregulated during the early, preinvasive stages of cervical carcinogenesis.

  9. High Oct4 expression is associated with neoplasm.

  10. A novel method using an inactivated viral particle to package and deliver four purified recombinant Yamanaka transcription factors (Sox2 (show SOX2 Proteins), Oct4, Klf4 (show KLF4 Proteins), and c-Myc (show MYC Proteins)) resulting in reprogramming of human primary fibroblasts has been described.

Pig (Porcine) POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Oct4-overexpression enhances porcine ovarian stem cell differentiation in to oocyte-like cells.

  2. showed novel molecular regulation of CDX2 (show CDX2 Proteins) on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 (show CDX2 Proteins) and Oct4 in embryo of mammals other than mouse

  3. Overexpression of Sox2 (show SOX2 Proteins) or Oct4 in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.

  4. Oct4 positive stem/progenitor swine lung epithelial cells are targets for influenza virus replication.

  5. study shows that localization of octamer-binding protein 4(OCT4) is associated with an embryonic stem cell (ESC)-like morphology from porcine inner cell mass

  6. OCT4 expression, in contrast to earlier speculations, at least in hatched blastocysts, resembles the expression pattern in the mouse embryo.

  7. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level.

  8. in the forming endoderm at the primitive streak stage, OCT4 was detectable in potential primordial germ cells only; in the ectoderm and mesodermal cell lineages OCT4 was cleared at the neural groove and somite stage, respectively

Cow (Bovine) POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. we concluded that OCT4 expression in somatic cells is not a good prognosis marker for selecting cell lines.

  2. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  3. Oct4 exhibited significant hypermethylation in sperm compared with that in oocytes

  4. In contrast to protein distribution, regulation of Oct4 transcription is conserved between mammalian species.

  5. analysis of CpG islands of bovine Leptin (show LEP Proteins) and POU5F1 genes in cloned bovine fetuses

  6. The restoration of pluripotency can be directly observed in living cells or SCNT embryos from such Pou5f1-EGFP transgenic fetuses.

Rabbit POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. sequences of mRNA and translated protein of the newly identified genes and those of POU5F1 were aligned to their mammalian orthologs to determine the degree of evolutionary conservation

  2. Higher values of OCT-4 expression were observed in embryos and endometrial tissue in females reproduced under heat conditions.

  3. protein expression during rabbit embryonic development: investigation of temporal and spatial relationship of expression of Oct-4, Cdx-2 (caudal type homeobox transcription factor 2 (show CDX2 Proteins)) and histone H4 (acetylated at lysine 5) in morula/blastocysts

  4. The signal may have reflected the regulation of Oct-4 through enhancer switching and therefore may be related to cell lineage formation in rabbit embryos.

  5. The POU5F1 gene is strictly regulated during early embryo development.

Rhesus Monkey POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Cytoplasmic CD44 (show CD44 Proteins) and absence of nuclear Oct3/4 suggest that the cells of cardiac sarcomas may represent 'daughter' stem cells that no longer have the capacity for tumour initiation, but have subsequently developed new lines of partial differentiation.

  2. Lack of restricted OCT4 protein, and inner cell mass localization of NANOG in primate blastocysts, suggests that NANOG may determine inner cell mass fate more specifically during primate development.

Mouse (Murine) POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Data show that the reprogramming factors OCT4, SOX2 (show SOX2 Proteins), KLF4 (show KLF4 Proteins), and MYC (show MYC Proteins) (OSKM) drive cells along two distinct and parallel pathways, one pluripotent and one endodermal.

  2. Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming.

  3. our study provides valuable information on the molecular interactions between OSKM(Oct4, Sox2 (show SOX2 Proteins), Klf4 (show KLF4 Proteins), and Myc (show MYC Proteins)) and cofactors and molecular mechanisms for the functional importance of Set1a in ESCs (show NR2E3 Proteins) and early development

  4. Hierarchical Oct4 binding in concert with primed epigenetic rearrangements during somatic cell reprogramming has been described.

  5. One-week administration of valproic acid followed by one-week forced expression of Oct4 enhanced myelination by converting transduced cells to myelinating oligodendrocytes

  6. Aurkb (show AURKB Proteins) phosphorylates Oct4(S229) during G2/M phase, leading to the dissociation of Oct4 from chromatin, whereas PP1 (show PPP1CC Proteins) binds Oct4 and dephosphorylates Oct4(S229) during M/G1 transition, which resets Oct4-driven transcription for pluripotency and the cell cycle.

  7. Bcl3 (show BCL3 Proteins) Bridges LIF (show LIF Proteins)-STAT3 (show STAT3 Proteins) to Oct4 Signaling in the Maintenance of Naive Pluripotency.

  8. Oct3/4 plays a crucial role in mediating CSCs to induce cardiac regeneration.

  9. OCT4-SOX2 (show SOX2 Proteins) configuration that dimerizes on a Hoxb1 (show HOXB1 Proteins)-like composite, a canonical element with juxtaposed individual binding sites, plays a more critical role in the induction and maintenance of pluripotency.

  10. The long noncoding RNA Gm15055 is highly expressed in mouse embryonic stem cells and its expression is maintained by OCT4.

Zebrafish POU Class 5 Homeobox 1 (POU5F1) interaction partners

  1. Regulation of mych by Pou5f1 appears to be direct transcriptional activation.

  2. The posttranslational modification by phosphorylation opens the possibility that Pou5f1 may be subject to temporal or region specific modulation of its activity or stability by embryonic signaling mechanisms.

  3. discuss mechanistic implications of simultaneous activation of transcriptional targets by ubiquitous, like Pou5f1, and region-specific inducers, emerging as a common regulatory motif in early development

  4. maternal Nanog (show NANOG Proteins), Pou5f1 and SoxB1 are required to initiate the zygotic developmental program and induce clearance of the maternal program by activating miR (show MYLIP Proteins)-430 expression

  5. thses data position Pou5f1 and SOX (show PIPOX Proteins)-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control.

  6. The defects due to HEP induction were rescued by introducing wild-type pou2 mRNA before the heat treatments.

  7. Vox plays a key role downstream of BMP signals in regulating the capacity of Nodal to induce endoderm versus mesoderm by modulating the activity of the Casanova/Pou2 regulatory system.

  8. Pou2 functions in multiple aspects of vertebrate development, especially in the binary decision of the mesendoderm to mesoderm and endoderm in different ways depending on the developmental stage.

  9. show that Pou5f1 binds to phylogenetically conserved Oct (show Plxna2 Proteins)/Pou5f1 sites in the vox promoter, both in vivo and in vitro

  10. The temporospatial structure of the zebrafish Pou5f1 target networks may explain aspects of the evolution of the mammalian stem cell networks.

OCT4 (POU5F1) Protein Profile

Protein Summary

This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6\;22)(p21\;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Gene names and symbols associated with POU5F1

  • POU class 5 homeobox 1 (POU5F1)
  • POU class 5 homeobox 1 (Pou5f1)
  • POU domain, class 5, transcription factor 1 (Pou5f1)
  • POU domain, class 5, transcription factor 3 (pou5f3)
  • cb197 protein
  • chunp6868 protein
  • gp-9 protein
  • gp9 protein
  • NF-A3 protein
  • Oct-3 protein
  • Oct-3/4 protein
  • Oct-4 protein
  • Oct3 protein
  • Oct3/4 protein
  • oct4 protein
  • Otf-3 protein
  • Otf-4 protein
  • Otf3 protein
  • Otf3-rs7 protein
  • Otf3g protein
  • Otf4 protein
  • POU-2 protein
  • pou2 protein
  • POU5F1 protein
  • POU5F1L protein
  • spg/pou2 protein
  • wu:fd18d06 protein

Protein level used designations for POU5F1

POU class 5 homeobox 1 , POU domain, class 5, transcription factor 1-like , POU domain class 5 transcription factor 1 , POU domain, class 5, transcription factor 1 , POU domain transcription factor OCT4 , POU-type homeodomain-containing DNA-binding protein , octamer-binding protein 3 , octamer-binding protein 4 , octamer-binding transcription factor 3 , octamer-binding transcription factor-3 , OTF-3 , oct-3 , Octamer-binding transcription factor 3 , oct-4 , octamer binding transcription factor 4 , spg , etID49452.21 , POU domain gene 2 , spiel ohne grenzen , spiel-ohne-grenzen , spiel ohne grenzen/pou2 , spiel-ohne-grenzen/pou2

735657 Pan troglodytes
100091458 Ornithorhynchus anatinus
100174788 Felis catus
100271853 Ornithorhynchus anatinus
100271854 Monodelphis domestica
100302349 Ovis aries
5460 Homo sapiens
481709 Canis lupus familiaris
100127461 Sus scrofa
282316 Bos taurus
100101567 Oryctolagus cuniculus
294562 Rattus norvegicus
714760 Macaca mulatta
744263 Pan troglodytes
18999 Mus musculus
30333 Danio rerio
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