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anti-PTEN Induced Putative Kinase 1 (PINK1) Antibodies

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. Additionally we are shipping PINK1 Proteins (12) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
PINK1 298575  
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Top anti-PINK1 Antibodies at antibodies-online.com

Showing 10 out of 229 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Rat Goat Un-conjugated ELISA, WB ABIN334460 (1µg/ml) staining of Rat Testis lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Goat Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated WB 0.1 mL Log in to see 5 to 7 Days
$381.94
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of anti-PARK6 Pab in mouse kidney tissue lysate. PARK6 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated SimWes, WB Western blot of C-terminally V5His-tagged human Pink1 or N-terminally myc-tagged human Pink1 expressed in HEK293T cells.  ABIN152067 detects transfected Pink1 protein. Simple Western: PINK1 Antibody [ABIN152067] - Simple Western lane view shows a specific band for PINK1 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mg Log in to see 5 to 7 Days
$317.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of Park6 (PINK1) C-term (ABIN652208) in mouse kidney tissue lysates (35 µg/lane). Park6 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: PINK1 Antibody (8E10.1D6) [NBP2-36488] - Whole cell protein from HeLa cells treated with or without valinomycin (1 uM for 24h) as indicated was separated by SDS-PAGE on a 7.5% polyacrylamide gel. Protein was transferred to PVDF membrane and probed with 2 ug/ml anti-PINK1 in 1% BSA and detected with an HRP-conjugated anti-mouse secondary antibody using chemiluminescence. PINK1 is seen to be upregulated at approximately 60 kDa (arrowhead) with treament. Western Blot: PINK1 Antibody (8E10.1D6) [NBP2-36488] - WB analysis of (A) 13kDa Partial Recombinant Human PINK-1 protein and (B) Human Liver lysate using PINK1 antibody clone 8E10.1D6 at 3ug/ml concentration. 0.1 mg Log in to see 5 to 7 Days
$408.19
Details
Human Rabbit Un-conjugated WB The anti-PINK1 C-term Pab (ABIN1882117) is used in Western blot to detect PINK1 in mouse heart tissue lysate. The anti-PINK1 C-term Pab (ABIN1882117) is used in Western blot to detect PINK1 in mouse heart tissue lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$283.50
Details

PINK1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-PINK1 Antibodies

  1. Human Polyclonal PINK1 Primary Antibody for WB - ABIN151937 : Meijer, Karimi-Busheri, Huang, Weinfeld, Young: Pnk1, a DNA kinase/phosphatase required for normal response to DNA damage by gamma-radiation or camptothecin in Schizosaccharomyces pombe. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN151937

  2. Human Polyclonal PINK1 Primary Antibody for WB - ABIN1882117 : Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. in Archives of neurology 2004 (PubMed)
    Show all 4 references for ABIN1882117

  3. Human Polyclonal PINK1 Primary Antibody for EIA, IHC (p) - ABIN358994 : Hatano, Li, Sato, Asakawa, Yamamura, Tomiyama, Yoshino, Asahina, Kobayashi, Hassin-Baer, Lu, Ng, Rosales, Shimizu, Toda, Mizuno, Hattori: Novel PINK1 mutations in early-onset parkinsonism. in Annals of neurology 2004 (PubMed)
    Show all 2 references for ABIN358994

  4. Human Monoclonal PINK1 Primary Antibody for ICC, IF - ABIN4345677 : Ko, Park, Park, Koh: PPAR-γ activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. in Toxicology letters 2016 (PubMed)

  5. Human Polyclonal PINK1 Primary Antibody for WB - ABIN652208 : Berthier, Jiménez-Sáinz, Pulido: PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1. in Proceedings of the National Academy of Sciences of the United States of America 2013 (PubMed)

  6. Rat (Rattus) Polyclonal PINK1 Primary Antibody for ELISA, WB - ABIN334460 : Chishti, Bohlega, Ahmed, Loualich, Carroll, Sato, St George-Hyslop, Westaway, Rogaeva: T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease. in Archives of neurology 2006 (PubMed)

More Antibodies against PINK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. PINK1-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  2. Clu (show CLU Antibodies) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  3. Human Mask homolog ANKHD1 (show ANKHD1 Antibodies) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin (show PARK2 Antibodies) mutations.

  4. Various ways of stimulation of the ETC (genetic, pharmacologic and mechanical) (Figure 1) all improve a Pink1 fly model.

  5. These results indicate that the in vivo rescue is due to restoring CI activity rather than promoting mitophagy Our findings support the emerging view that PINK1 plays a role in regulating complex I activity separate from its role with Parkin (show PARK2 Antibodies) in mitophagy

  6. MUL1 (show MUL1 Antibodies) acts in parallel to the PINK1/parkin (show PARK2 Antibodies) pathway on a shared target mitofusin (show MFN2 Antibodies) to maintain mitochondrial integrity.

  7. PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila.

  8. PINK1 cooperates with Parkin to promote hnRNP-F/Glo ubiquitination and nRCC mRNA translation.

  9. results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle

  10. PINK1 counteracts the neurotoxicity of PINK1 counteracts the neurotoxicity of mutant Htt (show HTT Antibodies).

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. Data suggest that PPARG (peroxisome proliferator-activated receptor gamma (show PPARG Antibodies)) protects against insecticide-induced cytotoxicity/apoptosis by regulating PINK1 (PTEN induced putative kinase 1) expression in neurons, including dopaminergic neurons; the insecticide used in these experiments was deltamethrin; the neuroprotective agent was the hypoglycemic agent, rosiglitazone.

  2. These findings pinpoint PINK1-short form as a sensor of proteasomal activities that transduces the proteasomal impairment signal to the aggresome formation machinery.

  3. Differential submitochondrial localization of PINK1 serves as a molecular switch for mediating two distinct mitochondrial signaling pathways in maintenance of mitochondrial homeostasis.

  4. Processing and shuttling of PINK1 through mitochondria is conformed to at least three possible functional microcompartments for PINK1 activity (I, cytosol; II, outer mitochondrial membrane; III, inside mitochondria).

  5. pathogenic PINK1 mutants which are not cleaved by PARL (show PARL Antibodies) affect PINK1 kinase activity and the ability to induce PARK2 (show PARK2 Antibodies)-mediated mitophagy.

  6. results indicate that PINK1 expression is positively regulated by NRF2 (show GABPA Antibodies) and that the NRF2 (show GABPA Antibodies)-PINK1 signaling axis is deeply involved in cell survival.

  7. High expression of PARK6 might lead to the occurrence of non-small-cell lung cancer.

  8. These results suggest that pyruvate is required for CCCP-induced PINK1/PARK2 (show PARK2 Antibodies)-mediated mitophagy.

  9. PINK1-PARK2 (show PARK2 Antibodies) pathway-mediated mitophagy plays a key regulatory role in CSE-induced mitochondrial ROS (show ROS1 Antibodies) production and cellular senescence in human bronchial epithelial cells

  10. Rab8A (show RAB8A Antibodies) GTPase (show RACGAP1 Antibodies) Ser (show SIGLEC1 Antibodies)(111) phosphorylation is not directly regulated by PINK1 in vitro and demonstrate in cells the time course of Ser (show SIGLEC1 Antibodies)(111) phosphorylation of Rab8A (show RAB8A Antibodies), 8B and 13 is markedly delayed compared to phosphorylation of Parkin (show PARK2 Antibodies) at Ser (show SIGLEC1 Antibodies)(65).

Mouse (Murine) PTEN Induced Putative Kinase 1 (PINK1) interaction partners

  1. lack of PINK1 causes increased excitatory transmission and neurotransmitter release in the hippocampus, which might lead to the cognitive decline often observed in Parkinson's disease

  2. The identification of PINK1 and Parkin (show PARK2 Antibodies) as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  3. PINK1 deficiency causes defects in GFAP (show GFAP Antibodies)-positive astrogliogenesis during brain development.

  4. The findings of this study show a CB1R (show CNR1 Antibodies) dysfunction at corticostriatal synapses in PINK1(-/-), but not in PINK1(+/-) mice, and provide a mechanistic link to the distinct plasticity deficits observed in both genotypes.

  5. Loss of PINK1 inhibits Ca2 (show CA2 Antibodies)+ efflux by NCLX (show SLC24A6 Antibodies) and triggers mitochondrial depolarization.

  6. PINK1 gene knockout can protect neonatal mice from hypoxic-ischemic brain damage (HIBD).

  7. Loss of Pink1 reprograms glucose metabolism through HIF1alpha (show HIF1A Antibodies), sustaining increased cell proliferation.

  8. findings support the notion that BAG2 (show BAG2 Antibodies) is an upstream regulator of the PINK1/PARKIN (show PARK2 Antibodies) signaling pathway.

  9. Interplay between E2F1 (show E2F1 Antibodies), miR421 and Pink1 regulates mitochondrial morphology and cardiomyocyte death. Pink1 reduces mitochondrial fragmentation and protects cardiomyocyte from apoptosis.

  10. data suggest that Parkin (show PARK2 Antibodies) recruitment to depolarized cardiac mitochondria and subsequent activation of mitophagy is independent of PINK1.

PINK1 Antigen Profile

Protein Summary

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Gene names and symbols associated with PINK1

  • PTEN-induced putative kinase 1 (Pink1) antibody
  • PTEN induced putative kinase 1 (PINK1) antibody
  • PTEN induced putative kinase 1 (pink1) antibody
  • PTEN induced putative kinase 1 (Pink1) antibody
  • 1190006F07Rik antibody
  • AU042772 antibody
  • AW557854 antibody
  • BEST:GH23468 antibody
  • BRPK antibody
  • CG4523 antibody
  • Dmel\\CG4523 antibody
  • dPink1 antibody
  • mFLJ00387 antibody
  • PARK6 antibody
  • PINK antibody
  • pink1 antibody
  • wu:fc39e12 antibody
  • zgc:101729 antibody

Protein level used designations for PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

GENE ID SPECIES
31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
Selected quality suppliers for anti-PINK1 (PINK1) Antibodies
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