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Poly(rC) Binding Protein 2 Proteins (PCBP2)

The protein encoded by PCBP2 appears to be multifunctional. Additionally we are shipping PCBP2 Antibodies (59) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PCBP2 5094 Q15366
PCBP2 18521 Q61990
Rat PCBP2 PCBP2 363005  
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Top PCBP2 Proteins at

Showing 4 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

PCBP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

Top referenced PCBP2 Proteins

  1. Human PCBP2 Protein expressed in Human - ABIN2728353 : Školáková, Foldynová-Trantírková, Bednářová, Fiala, Vorlíčková, Trantírek: Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA. in Nucleic acids research 2015 (PubMed)

  2. Human PCBP2 Protein expressed in Wheat germ - ABIN1314129 : Wang, Jeng, Lai et al.: Poly(C)-binding protein 2 interacts with sequences required for viral replication in the hepatitis C virus (HCV) 5' untranslated region and directs HCV RNA replication through circularizing the viral ... in Journal of virology 2011 (PubMed)

More Proteins for Poly(rC) Binding Protein 2 (PCBP2) Interaction Partners

Human Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. PCBP2 was overexpressed in esophageal squamous cell carcinoma tissues and cell lines. PCBP2 expression promoted proliferation of ESCC cells. We also found that reduced PCBP2 expression might induce ESCC cell apoptosis with increased cleaved caspase3 expression. Overall, our findings indicated that PCBP2 might be involved in the ESCC progression and be considered as a new treatment target in ESCC.

  2. High expression of PCBP2 may contribute to sorafenib resistance in hepatocellular carcinoma cells.

  3. our data indicate that miR (show MLXIP Proteins)-214 may function as tumor suppressor in glioma by targeting PCBP2

  4. beta2-adrenergic receptor (show ADRB2 Proteins) signaling promotes pancreatic ductal adenocarcinoma progression by facilitating PCBP2-dependent c-myc (show MYC Proteins) expression.

  5. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.

  6. Protein and mRNA levels of PCBP2 were down-regulated under insulin (show INS Proteins)-resistant conditions. Over-expression of PCBP2 inhibits HIF1alpha (show HIF1A Proteins) and STAT3 (show STAT3 Proteins) pathway.

  7. STAT3 (show STAT3 Proteins) functions via cellular PCBP2 to regulate B-cell lytic susceptibility by restraining Epstein-Barr Virus lytic activation.

  8. PCBP1 (show PCBP1 Proteins) and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells.

  9. PCBP2-depletion induces apoptosis in gastric cancer cells via up-regulating expression of pro-apoptotic proteins and down-regulating anti-apoptotic proteins. miR (show MLXIP Proteins)-34a is a target of PCBP2, and miR (show MLXIP Proteins)-34a is critically essential for the function of PCBP2.

  10. SIRT6 (show SIRT6 Proteins) inhibits glioma cell proliferation and colony formation in vitro and glioma cell growth in vivo in a PCBP2 dependent manner. SIRT6 (show SIRT6 Proteins) inhibits PCBP2 expression through deacetylating H3K9ac and SIRT6 (show SIRT6 Proteins) acts as a tumor suppressor in glioma.

Mouse (Murine) Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. data suggest that PCBP2 regulates p73 (show ARHGAP24 Proteins) expression via mRNA stability and p73 (show ARHGAP24 Proteins)-dependent biological function in ROS (show ROS1 Proteins) production and cellular senescence.

  2. PCBP2 overexpression rescues the Meis1 (show MEIS1 Proteins) effects of Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) pathway and hypertrophy of cardiomyocytes.

  3. These data reveal that Pcbp1 (show PCBP1 Proteins) and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.

  4. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.

  5. Our analysis of PCBP1 (show PCBP1 Proteins) and PCBP2 expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.

  6. This study demonstrates for the first time that alpha-CP2 functions as a transcriptional activator by binding to a single-stranded poly(C) sequence.

  7. This study provides evidence that PCBP2 and hnRNP A1 (show HNRNPA1 Proteins) bind to the 5' and 3' ends of the murine norovirus 1 viral RNA and contribute to RNA circularization, playing a role in the virus life cycle.

  8. PCBP2-AIP4 (show ITCH Proteins) axis defines a new signaling cascade for MAVS (show MAVS Proteins) degradation and 'fine tuning' of antiviral innate immunity.

Pig (Porcine) Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. These results indicated that Nsp1beta of porcine reproductive and respiratory syndrome virus is able to bind and interact with cellular PCBP2 strongly in both the infected cells and plasmid transfected cells.

  2. Overall, the results presented here point toward an important role for PCBP1 (show PCBP1 Proteins) and PCBP2 in regulating porcine reproductive and respiratory syndrome virus RNA synthesis via binding to viral nonstructural protein 1beta.

PCBP2 Protein Profile

Protein Summary

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PCBP2

  • poly(rC) binding protein 3 (pcbp3)
  • poly(rC) binding protein 2 (pcbp2)
  • poly(rC) binding protein 2 (PCBP2)
  • poly(rC) binding protein 2 (Pcbp2)
  • poly(rC) binding protein 3 (PCBP3)
  • alphaCP-2 protein
  • AW412548 protein
  • fb36h02 protein
  • hnRNP-E2 protein
  • HNRNPE2 protein
  • HNRPE2 protein
  • Hnrpx protein
  • PCBP2 protein
  • PCBP3 protein
  • wu:fb36h02 protein
  • zgc:55964 protein

Protein level used designations for PCBP2

poly(rC) binding protein 2 , poly(rC) binding protein 3 , poly(rC)-binding protein 2 , PolyrC-binding protein 2 , poly(rc)-binding protein 2 , alpha-CP2 , heterogeneous nuclear ribonucleoprotein E2 , heterogenous nuclear ribonucleoprotein E2 , hnRNP E2 , CBP , CTBP , heterogeneous nuclear ribonucleoprotein X , hnRNP X , putative heterogeneous nuclear ribonucleoprotein X , heterogeneous nuclear ribonucleoprotein

448044 Xenopus (Silurana) tropicalis
733863 Xenopus (Silurana) tropicalis
100194880 Salmo salar
100528911 Ictalurus punctatus
5094 Homo sapiens
477596 Canis lupus familiaris
540653 Bos taurus
18521 Mus musculus
363005 Rattus norvegicus
321844 Danio rerio
399399 Xenopus laevis
397665 Sus scrofa
420965 Gallus gallus
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