PCBP2 Products
(Poly(rC) Binding Protein 2 (PCBP2))
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The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured PCBP2 Categories
PCBP2 Antibodies
High quality antibodies with extensive validation data.
PCBP2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PCBP2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, ICC, IHC (p), IP
Validations
- (1)
- (6)
Cat. No.
ABIN2856965
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), RNAi
Validations
- (9)
- (8)
Cat. No.
ABIN562121
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (8)
Cat. No.
ABIN3023340
Quantity
100 μL
Datasheet
Datasheet
Recommended PCBP2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6208966
Quantity
96 tests
Datasheet
Datasheet
Recommended PCBP2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1314129
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1314131
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3085703
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PCBP2 products
: "Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation." in: Biochimica et biophysica acta. General subjects, Vol. 1863, Issue 3, pp. 547-564, (2019) (PubMed).: "Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X." in: Molecular cell, Vol. 74, Issue 1, pp. 101-117.e10, (2019) (PubMed).
: "Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos." in: Scientific reports, Vol. 7, Issue 1, pp. 4022, (2018) (PubMed).
: "Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion." in: Oncotarget, Vol. 7, Issue 15, pp. 19483-98, (2016) (PubMed).
: "Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2." in: The Journal of biological chemistry, Vol. 291, Issue 33, pp. 17303-18, (2016) (PubMed).
: "Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA." in: Nucleic acids research, Vol. 43, Issue 9, pp. 4733-45, (2015) (PubMed).
: "hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication." in: Journal of virology, Vol. 88, Issue 13, pp. 7199-209, (2014) (PubMed).
: "Dissecting noncoding and pathogen RNA-protein interactomes." in: RNA (New York, N.Y.), Vol. 21, Issue 1, pp. 135-43, (2014) (PubMed).
: "RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3." in: The Journal of clinical investigation, Vol. 123, Issue 5, pp. 2103-18, (2013) (PubMed).
: "Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules." in: Nucleic acids research, Vol. 40, Issue 16, pp. 8099-110, (2012) (PubMed).
Synonyms and alternative names related to PCBP2
poly(rC) binding protein 2 (PCBP2), poly(rC) binding protein 2 (Pcbp2), poly(rC) binding protein 2 (pcbp2), poly(rC) binding protein 2 L homeolog (pcbp2.L), alphaCP-2, AW412548, fb36h02, hnRNP-E2, HNRNPE2, HNRPE2, Hnrpx, PCBP2, PCBP3, wu:fb36h02, zgc:55964Protein level used designations for PCBP2
- alpha-CP2
- heterogeneous nuclear ribonucleoprotein E2
- heterogenous nuclear ribonucleoprotein E2
- hnRNP E2
- poly(rC)-binding protein 2
- CBP
- CTBP
- heterogeneous nuclear ribonucleoprotein X
- hnRNP X
- putative heterogeneous nuclear ribonucleoprotein X
- poly(rC) binding protein 2
- poly(rC) binding protein 3
- PolyrC-binding protein 2
- poly(rc)-binding protein 2
- heterogeneous nuclear ribonucleoprotein
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