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The product of P2RY12 belongs to the family of G-protein coupled receptors. Additionally we are shipping P2RY12 Antibodies (31) and P2RY12 Kits (18) and many more products for this protein.
Showing 4 out of 4 products:
AHR (show AHR Proteins) and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma.
quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury
Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity.
P2RY12-mediated activation of juxtavascular microglial cells contributes to the rapid closure of small openings in the BBB.
study reports robust involvement of P2Y12R in inflammatory pain: anti-hyperalgesic effect of P2Y12R antagonism could be mediated by the inhibition of both central and peripheral cytokine production and involves alpha7-receptor mediated efferent pathways
demonstrating that these P2Y12 inhibitors may not be effective in preventing early disease
indicate that P2Y12R undergoes slow desensitization; ADP-P2Y12 signaling is tightly regulated by Entpd1 (show ENTPD1 Proteins)/Nt5e (show NT5E Proteins) activity and adenosine receptors
P2Y12 signaling is required for stabilizing platelet thrombi.
Platelet P2Y12 is involved in murine pulmonary metastasis.
The P2Y12 receptor plays an important role during lipopolysaccharide-induced inflammation.
The Conundrum of Platelet P2Y12 Inhibition in ST-Segment Elevation Myocardial Infarction.
P2Y12R gene rs2046934 C>T and rs3732759 A>G polymorphisms might be associated with the risk of coronary artery disease and the efficacy of clopidogrel treatment for CAD.
No association was found in genotype frequencies of P2Y12 and responsiveness to clopidogrel in coronary heart disease patients of Han ethnicity.
P2Y12 inhibitor monotherapy and dual antiplatelet therapy inhibit hemostatic system activation to a comparable extent in healthy volunteers.
In the presence of loss of function C34T polymorphism of P2Y12 receptor, smoking is associated with increased adverse cardiovascular outcome in coronary artery disease patients.
These data strongly suggest that P2Y12 may represent an important pharmacological target for the treatment of patients with allergic bronchial asthma. [review]
Report appropriate P2Y12 inhibitor regimen to prevent increased bleeding risk and maintain antiplatelet efficacy in East Asian patients with acute coronary syndrome. in Korean patients
Baseline platelet aggregation was increased in carriers of the common alleles of P2Y12 SNPs rs1907637, rs2046934, and rs6809699 and rs6787801 TC heterozygotes.
The ratio of ADP- to TRAP-induced platelet aggregation quantifies P2Y12-dependent platelet inhibition independently of the platelet count in contrast to conventional ADP-induced aggregation.
Synergistic inhibition of both P2Y1 (show P2RY1 Proteins) and P2Y12 adenosine diphosphate receptors by GLS (show GLS Proteins)-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.
P2Y purinoceptor 12
, ADP-glucose receptor
, G-protein coupled receptor SP1999
, Gi-coupled ADP receptor HORK3
, P2Y12 platelet ADP receptor
, purinergic receptor P2RY12
, putative G-protein coupled receptor