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Purinergic Receptor P2Y, G-Protein Coupled, 12 Proteins (P2RY12)

The product of P2RY12 belongs to the family of G-protein coupled receptors. Additionally we are shipping P2RY12 Antibodies (27) and P2RY12 Kits (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
P2RY12 70839 Q9CPV9
P2RY12 64805 Q9H244
P2RY12 64803 Q9EPX4
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Top P2RY12 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Chimpanzee Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

P2RY12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

Rat (Rattus)

More Proteins for Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) Interaction Partners

Mouse (Murine) Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) interaction partners

  1. Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity.

  2. P2RY12-mediated activation of juxtavascular microglial cells contributes to the rapid closure of small openings in the BBB.

  3. study reports robust involvement of P2Y12R in inflammatory pain: anti-hyperalgesic effect of P2Y12R antagonism could be mediated by the inhibition of both central and peripheral cytokine production and involves alpha7-receptor mediated efferent pathways

  4. demonstrating that these P2Y12 inhibitors may not be effective in preventing early disease

  5. indicate that P2Y12R undergoes slow desensitization; ADP-P2Y12 signaling is tightly regulated by Entpd1 (show ENTPD1 Proteins)/Nt5e (show NT5E Proteins) activity and adenosine receptors

  6. P2Y12 signaling is required for stabilizing platelet thrombi.

  7. Platelet P2Y12 is involved in murine pulmonary metastasis.

  8. The P2Y12 receptor plays an important role during lipopolysaccharide-induced inflammation.

  9. P2Y12 participates in ischemia related inflammation by mediating microglial migration and potentiation of neurotoxicity.

  10. This study demonistrated that environment enhanced P2Y12 expression in brain and enhanced totaroad perfermance and short term working menory.

Human Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) interaction partners

  1. Baseline platelet aggregation was increased in carriers of the common alleles of P2Y12 SNPs rs1907637, rs2046934, and rs6809699 and rs6787801 TC heterozygotes.

  2. The ratio of ADP- to TRAP-induced platelet aggregation quantifies P2Y12-dependent platelet inhibition independently of the platelet count in contrast to conventional ADP-induced aggregation.

  3. Synergistic inhibition of both P2Y1 (show P2RY1 Proteins) and P2Y12 adenosine diphosphate receptors by GLS (show GLS Proteins)-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.

  4. PON1 (show PON1 Proteins), P2Y12 and COX1 polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.

  5. In non-ST elevation acute coronary syndrome patients undergoing PCI a loading dose of ticagrelor or prasugrel given during the procedure provides optimal P2Y12-ADP receptor blockade in 2 h and maximal inhibition within 4 h.

  6. While there is increasing evidence for the cancer-protective effect of aspirin, this study suggests P2Y12 inhibition may also play a role.

  7. Establish a reliable antiplatelet profile of SAR216471, and support its potential use in clinical practice as an alternative to currently available P2Y12 receptor antagonists.

  8. 2 functional single nucleotide polymorphisms of PON1 gene (rs662 and rs854560) and 3 variants of the P2RY12 gene (rs2046934, rs6798347, rs6801273) in samples pooled from average Hungarian Roma and Hungarian population samples, were investigated.

  9. coexisting polymorphisms of CYP3A5 (show CYP3A5 Proteins)*3 and 2C19*2, but not P2Y12*1, play an important role in the variability of clopidogrel's curative effect

  10. ADP stimulation of P2Y12 led to cAMP decrease that, in turn, caused changes in phospholipase C (show PLC Proteins) phosphorylation by protein kinase A, increase in cytoplasmic calcium level and, consequently, PS+ platelet formation

P2RY12 Protein Profile

Protein Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

Gene names and symbols associated with P2RY12

  • purinergic receptor P2Y, G-protein coupled 12 (P2ry12)
  • purinergic receptor P2Y, G-protein coupled, 12 (P2RY12)
  • purinergic receptor P2Y, G-protein coupled, 12 (P2ry12)
  • 2900079B22Rik protein
  • 4921504D23Rik protein
  • ADPG-R protein
  • BDPLT8 protein
  • HORK3 protein
  • P2T(AC) protein
  • P2Y(12)R protein
  • P2Y(AC) protein
  • P2Y(ADP) protein
  • P2Y(cyc) protein
  • P2y12 protein
  • SP1999 protein

Protein level used designations for P2RY12

P2Y purinoceptor 12 , ADP-glucose receptor , G-protein coupled receptor SP1999 , Gi-coupled ADP receptor HORK3 , P2Y12 platelet ADP receptor , purinergic receptor P2RY12 , putative G-protein coupled receptor

70839 Mus musculus
64805 Homo sapiens
64803 Rattus norvegicus
442958 Canis lupus familiaris
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