Purinergic Receptor P2Y, G-Protein Coupled, 12 Proteins (P2RY12)

The product of P2RY12 belongs to the family of G-protein coupled receptors. Additionally we are shipping P2RY12 Antibodies (30) and P2RY12 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
P2RY12 70839 Q9CPV9
P2RY12 64805 Q9H244
P2RY12 64803 Q9EPX4
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Top P2RY12 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Chimpanzee Un-conjugated   5 applications Log in to see 1 to 2 Days

P2RY12 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
Rat (Rattus)

More Proteins for Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) Interaction Partners

Mouse (Murine) Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) interaction partners

  1. Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin (show CFL1 Proteins) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.

  2. P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis.

  3. excessive mechanical stress may induce a sustained release of ADP and promote SMC senescence via P2ry12-dependent sustained Ras activation, thereby contributing to excessive inflammation and degeneration, which provides insights into TAAD formation and progression.

  4. AHR (show AHR Proteins) and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma.

  5. quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury

  6. Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity.

  7. P2RY12-mediated activation of juxtavascular microglial cells contributes to the rapid closure of small openings in the BBB.

  8. study reports robust involvement of P2Y12R in inflammatory pain: anti-hyperalgesic effect of P2Y12R antagonism could be mediated by the inhibition of both central and peripheral cytokine production and involves alpha7-receptor mediated efferent pathways

  9. demonstrating that these P2Y12 inhibitors may not be effective in preventing early disease

  10. indicate that P2Y12R undergoes slow desensitization; ADP-P2Y12 signaling is tightly regulated by Entpd1 (show ENTPD1 Proteins)/Nt5e (show NT5E Proteins) activity and adenosine receptors

Human Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) interaction partners

  1. studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation.

  2. apart from the established association of the CYP2C19 *2 and *3 LOF alleles with high on-treatment platelet reactivity (HTPR), haplotypes of P2RY12 rs6798347, rs6787801, rs6801273, and rs6785930 rather than rs2046934 (T744C) that related to pharmacodynamics of clopidogrel in patients with ACS were independently associated with HTPR

  3. The present report illustrates an update of dysfunctional platelet P2Y12R mutations diagnosed with congenital lifelong bleeding problems. [review]

  4. aim of this study was to evaluate the effects of platelet receptor gene (P2Y12, P2Y1 (show P2RY1 Proteins)) and glycoprotein gene (GPIIIa (show ITGB3 Proteins)) polymorphisms, as well as their interactions, on antiplatelet drug responsiveness and clinical outcomes in patients with acute MIS (show AMH Proteins)

  5. The Conundrum of Platelet P2Y12 Inhibition in ST-Segment Elevation Myocardial Infarction.

  6. P2Y12R gene rs2046934 C>T and rs3732759 A>G polymorphisms might be associated with the risk of coronary artery disease and the efficacy of clopidogrel treatment for CAD.

  7. No association was found in genotype frequencies of P2Y12 and responsiveness to clopidogrel in coronary heart disease patients of Han ethnicity.

  8. P2Y12 inhibitor monotherapy and dual antiplatelet therapy inhibit hemostatic system activation to a comparable extent in healthy volunteers.

  9. In the presence of loss of function C34T polymorphism of P2Y12 receptor, smoking is associated with increased adverse cardiovascular outcome in coronary artery disease patients.

  10. These data strongly suggest that P2Y12 may represent an important pharmacological target for the treatment of patients with allergic bronchial asthma. [review]

P2RY12 Protein Profile

Protein Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

Gene names and symbols associated with P2RY12

  • purinergic receptor P2Y, G-protein coupled 12 (P2ry12)
  • purinergic receptor P2Y, G-protein coupled, 12 (P2RY12)
  • purinergic receptor P2Y, G-protein coupled, 12 (P2ry12)
  • 2900079B22Rik protein
  • 4921504D23Rik protein
  • ADPG-R protein
  • BDPLT8 protein
  • HORK3 protein
  • P2T(AC) protein
  • P2Y(12)R protein
  • P2Y(AC) protein
  • P2Y(ADP) protein
  • P2Y(cyc) protein
  • P2y12 protein
  • SP1999 protein

Protein level used designations for P2RY12

P2Y purinoceptor 12 , ADP-glucose receptor , G-protein coupled receptor SP1999 , Gi-coupled ADP receptor HORK3 , P2Y12 platelet ADP receptor , purinergic receptor P2RY12 , putative G-protein coupled receptor

70839 Mus musculus
64805 Homo sapiens
64803 Rattus norvegicus
442958 Canis lupus familiaris
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