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Runt-Related Transcription Factor 1 Proteins (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Antibodies (259) and RUNX1 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top RUNX1 Proteins at

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

RUNX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
Rat (Rattus)

More Proteins for Runt-Related Transcription Factor 1 (RUNX1) Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Runx1 has an important role in Nf1 (show NF1 Proteins) neurofibroma initiation

  2. RUNX1 and ER occupy adjacent elements in AXIN1 (show AXIN1 Proteins)'s second intron, and RUNX1 antagonizes oestrogen-mediated AXIN1 (show AXIN1 Proteins) suppression.

  3. A high level of Runx1 mRNA expression was detected on days 6-8 of pregnancy and under artificial decidualization. Data suggest that Runx1 may play an important role during mouse decidualization.

  4. Results suggest that Runx1 is involved in targeting ventrocaudal hypoglossal neurons to specific muscles but is not necessary for neuronal survival, motoneuron specification, or synaptic development

  5. Setbp1 (show SETBP1 Proteins) overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1

  6. Runx1-deficient hematopoietic stem and progenitor cells (HSPCs) have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis.

  7. mutation of the five Src (show SRC Proteins)-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa (show CEBPA Proteins) and granulocyte colony formation by Runx1-deleted murine marrow.

  8. Runx1 is an important participant in the pathology of muscle wasting diseases.

  9. Having characterized the extensive activity of P1, we utilized a P1-GFP homozygous mouse model to analyze the impact of the complete absence of Runx1 P1 expression in adult mice and observed strong defects in the T cell lineage.

  10. Sox17 (show SOX17 Proteins) inhibition of Runx1 and Gata2 (show GATA2 Proteins) maintains endothelial fate in endothelial-to-haematopoietic transition

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Germline RUNX1 mutations are associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia (show BCL11A Proteins).

  2. Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A (show SIN3A Proteins) and TCF12 (show TCF12 Proteins) in myeloid leukemia (show BCL11A Proteins).

  3. RUNX1-Evi-1 may promote proliferation and apoptosis resistance of primitive hematopoietic cell, and inhibit the differentiation of myeloid cells with the synergy of different pathways and factors.

  4. Thus, an NGF (show NGFB Proteins)/TrkA (show NTRK1 Proteins)-MAPK (show MAPK1 Proteins)-CBFbeta (show CBFB Proteins) pathway converges with Islet1 (show ISL1 Proteins)-Runx1 signaling to promote Runx1/CBFbeta (show CBFB Proteins) holocomplex formation and nonpeptidergic nociceptor maturation.

  5. Exon splicing patterns in the human RUNX1-RUNX1T1 (show RUNX1T1 Proteins) fusion gene present in acute myeloid leukemia (show BCL11A Proteins) patients have been decoded.

  6. we observed that inhibition of RUNX1/ETO (show RUNX1T1 Proteins) in Kasumi1 cells and in RUNX1/ETO (show RUNX1T1 Proteins) positive primary acute myeloid leukemia (show BCL11A Proteins) patient samples leads to up-regulation of miR144/451

  7. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1-ETO (show RUNX1T1 Proteins)/RUNX1-RUNX1T1 (show RUNX1T1 Proteins) is facilitated by interaction with the chaperonin (show HSPD1 Proteins) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (show HSP70 Proteins)).

  8. We conclude that the distal P1-Runx1 promoter is a direct transcriptional target of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling that may be important in normal hematopoiesis or its transition into malignant stem cells during the onset or progression of leukemia.

  9. RUNX1 amplification may predispose to early thrombotic events in children with B-cell acute lymphoblastic leukemia

  10. in hematopoietic cells RUNX1 protein is recruited to its own promoter to regulate RUNX1 gene transcription in a positive feedback loop.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Proteins) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Proteins) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Proteins), or cohesin subunit Smc3 (show SMC3 Proteins), fail to express runx3 (show RUNX3 Proteins) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Proteins) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt-related transcription factor 1 (runx1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 protein
  • aml protein
  • aml-1 protein
  • Aml1 protein
  • aml1-evi-1 protein
  • amlcr1 protein
  • cbfa2 protein
  • evi-1 protein
  • Pebp2a2 protein
  • pebp2ab protein
  • Pebpa2b protein
  • Runx-1 protein
  • runx1 protein
  • runxa protein
  • XAML protein
  • Xaml1 protein

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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