Runt-Related Transcription Factor 1 (RUNX1) ELISA Kits

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Antibodies (277) and RUNX1 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top RUNX1 ELISA Kits at antibodies-online.com

Showing 4 out of 14 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Rat 6.25 pg/mL 25-1600 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
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Human
  96 Tests Log in to see 2 to 3 Days
$480.00
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Human
  96 Tests Log in to see 6 Days
$642.86
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Human
  96 Tests Log in to see 1 to 2 Days
$898.33
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More ELISA Kits for RUNX1 Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Leukaemogenesis by AML1-ETO (show RUNX1T1 ELISA Kits) requires enhanced C/D box snoRNA/RNP (show RNPC3 ELISA Kits) formation.

  2. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 ELISA Kits)-activatable receptor PAR-1 (protease-activated receptor-1 (show F2R ELISA Kits)), in Runx1/Cbfb (show CBFB ELISA Kits)-deleted MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) cells. Similar to the effect of Runx1/Cbfb (show CBFB ELISA Kits) deletion, PAR-1 (show MARK2 ELISA Kits) overexpression induced CDKN1A/p21 (show CDKN1A ELISA Kits) expression and attenuated proliferation in MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) cells

  3. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  4. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  5. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (show TLR4 ELISA Kits) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (show NFKB1 ELISA Kits) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (show NFKB1 ELISA Kits) signaling pathway.

  6. both repressor and activator functions of Runx1 at multiple hematopoietic stages and lineages likely contribute to the tumor suppressor activity in MDS (show MECOM ELISA Kits) and AML.

  7. Knock-down of PLC-gamma-1 (show PLCG1 ELISA Kits) induced foreign body giant cell formation.PLC-gamma-1-deficiency caused a decrease in RUNX1 and subsequent PU.1 upregulation while subsequent rescue of RUNX1 in sh-PLC-gamma-1 (show PLCG1 ELISA Kits)-transfected cells strongly inhibited foreign body giant cell formation.

  8. this study shows that distinct, asynchronous and stage-specific transcription factors (TCF-1 (show HNF1A ELISA Kits), GATA-3 (show GATA3 ELISA Kits) and Runx1) activate Bcl11b (show BCL11B ELISA Kits) for T cell commitment

  9. Inhibition of Runx1 in multipotential myeloid precursor cells is important for osteoclast formation and function.

  10. Silencing of Runx1 attenuated the LPS (show TLR4 ELISA Kits)-induced IL-1beta (show IL1B ELISA Kits) and IL-6 (show IL6 ELISA Kits) production levels, but the TNF-alpha (show TNF ELISA Kits) levels were not affected. Overexpression of RUNX1 promoted IL-1beta (show IL1B ELISA Kits) and IL-6 (show IL6 ELISA Kits) production in response to LPS (show TLR4 ELISA Kits) stimulation.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Leukaemogenesis by AML1-ETO (show RUNX1T1 ELISA Kits) requires enhanced C/D box snoRNA/RNP (show RNPC3 ELISA Kits) formation.

  2. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 ELISA Kits)-activatable receptor PAR-1 (protease-activated receptor-1 (show F2R ELISA Kits)), in Runx1/Cbfb (show CBFB ELISA Kits)-deleted MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) cells. Similar to the effect of Runx1/Cbfb (show CBFB ELISA Kits) deletion, PAR-1 (show MARK2 ELISA Kits) overexpression induced CDKN1A/p21 (show CDKN1A ELISA Kits) expression and attenuated proliferation in MLL (show MLL ELISA Kits)-AF9 (show MLLT3 ELISA Kits) cells

  3. LRG1 (show LRG1 ELISA Kits) plays a crucial role in the proliferation and apoptosis of colorectal cancer (CRC (show CALR ELISA Kits)) by regulating RUNX1 expression.

  4. RUNX1 RNA and protein are upregulated in proliferative diabetic retinopathy and in response to high glucose in vitro. Immunohistochemical staining for RUNX1 showed reactivity in vessels of patient-derived fibrovascular membranes, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  5. RUNX1 overexpression induced partial DNA demethylation at SPI1 (show SPI1 ELISA Kits) proximal promoter.

  6. mutations in the SRSF2 (show SRSF2 ELISA Kits)/ASXL1 (show ASXL1 ELISA Kits)/RUNX1 gene panel identified as significant prognostic markers in systemic mastocytosis

  7. HHEX (show HHEX ELISA Kits) could replace RUNX1 in cooperating with FLT3 (show FLT3 ELISA Kits)-ITD to induce Acute myeloid leukemia (show BCL11A ELISA Kits) (AML).

  8. RUNX1-mutated AML is associated with a complex mutation cluster and is correlated with distinct clinico-pathologic features and inferior prognosis.

  9. It was found that the absence of mutations in the SRSF2 (show SRSF2 ELISA Kits), ASXL1 (show ASXL1 ELISA Kits), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

  10. Our findings suggest ETV6 (show ETV6 ELISA Kits)-RUNX1 is associated with space-time clustering of childhood leukemia (CL) and are consistent with an infection interacting with that oncogene (show RAB1A ELISA Kits) in early life leading to clinical leukemia.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF ELISA Kits) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 ELISA Kits) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 ELISA Kits), or cohesin subunit Smc3 (show SMC3 ELISA Kits), fail to express runx3 (show RUNX3 ELISA Kits) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 ELISA Kits) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen Profile

Antigen Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor (runt) antibody
  • runt related transcription factor 1 (Runx1) antibody
  • runt-related transcription factor 1 (runx1) antibody
  • runt-related transcription factor 1 (Runx1) antibody
  • AI462102 antibody
  • aml antibody
  • aml-1 antibody
  • Aml1 antibody
  • aml1-evi-1 antibody
  • amlcr1 antibody
  • cbfa2 antibody
  • evi-1 antibody
  • Pebp2a2 antibody
  • pebp2ab antibody
  • Pebpa2b antibody
  • Runx-1 antibody
  • runx1 antibody
  • runxa antibody
  • XAML antibody
  • Xaml1 antibody

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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