Runt-Related Transcription Factor 1 Proteins (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Antibodies (284) and RUNX1 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top RUNX1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,263.33
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,300.00
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$480.00
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HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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RUNX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Top referenced RUNX1 Proteins

  1. Human RUNX1 Protein expressed in HEK-293 Cells - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

More Proteins for Runt-Related Transcription Factor 1 (RUNX1) Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 (show AQP5 Proteins) protein of the acinar cells in the SMG (show SNRPG Proteins) in order to allow for the proper secretion of saliva (show RAG1AP1 Proteins)

  2. High RUNX1 expression is associated with skin squamous cell carcinoma.

  3. deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Proteins)- and NOTCH1 (show NOTCH1 Proteins)-regulated genes, including the MYB (show MYB Proteins) and MYC (show MYC Proteins) oncogenes, respectively.

  4. results demonstrate that RUNX1, when uncoupled from the requirement for cooperative ETS1 binding, is sufficient to drive long-range loop formation by the enhancer Ebeta, nucleosome clearance at its target promoters, and full transcriptional activation of the TCR beta recombination center

  5. hemogenic competency in recently specified endothelial progenitors is restrained through the active silencing of Runx1 expression.

  6. Leukaemogenesis by AML1-ETO (show RUNX1T1 Proteins) requires enhanced C/D box snoRNA/RNP (show RNPC3 Proteins) formation.

  7. In this study, we found upregulation of several hemostasis-related genes, including the thrombin (show F2 Proteins)-activatable receptor PAR-1 (protease-activated receptor-1 (show F2R Proteins)), in Runx1/Cbfb (show CBFB Proteins)-deleted MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells. Similar to the effect of Runx1/Cbfb (show CBFB Proteins) deletion, PAR-1 (show MARK2 Proteins) overexpression induced CDKN1A/p21 (show CDKN1A Proteins) expression and attenuated proliferation in MLL (show MLL Proteins)-AF9 (show MLLT3 Proteins) cells

  8. Immunohistochemical staining for RUNX1 showed reactivity in angiogenic tufts in the retina of mice with oxygen-induced retinopathy, suggesting that RUNX1 upregulation is a hallmark of aberrant retinal angiogenesis.

  9. The Runx1-persistent group is involved in transmitting mechanical and thermal information, whereas the Runx1-transient group transmits pruriceptive information. Such hierarchical control mechanisms may provide a developmental solution for the formation of sensory circuits that transmit distinct modalities.

  10. RUNX1 was expressed in both mesenchymal and epithelial compartments of the developing and postnatal lung. Increased respiratory distress, inflammation, and proinflammatory cytokines were observed in the Runx1-deleted mice after pulmonary LPS (show TLR4 Proteins) exposure. RUNX1 deletion was associated with the activation of NF-kappaB (show NFKB1 Proteins) in respiratory epithelial cells. RUNX1 was required for the suppression of NF-kappaB (show NFKB1 Proteins) signaling pathway.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. discussion of the role of RUNX1 in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 expression

  3. deficiency alters the expression of a crucial subset of TAL1 (show TAL1 Proteins)- and NOTCH1 (show NOTCH1 Proteins)-regulated genes, including the MYB (show MYB Proteins) and MYC (show MYC Proteins) oncogenes, respectively.

  4. Our findings strengthen previous data concerning RUNX1 mutations in acute myeloid leukemia (show BCL11A Proteins) and support the notion that RUNX1 mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (show BCL11A Proteins).

  5. Heterozygous germ line mutations in the RUNX1 gene are responsible genetic events for FPD/AML.

  6. Data suggest that RUNX1 pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1, either mutations in RUNX1 gene or variations in expression of RUNX1, appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  7. The E3 ubiquitin ligase (show MUL1 Proteins) STUB1 (show STUB1 Proteins) is a negative regulator of both RUNX1 and RUNX1-RUNX1T1 (show RUNX1T1 Proteins). Activation of STUB1 (show STUB1 Proteins) could be a promising therapeutic strategy for RUNX1-RUNX1T1 (show RUNX1T1 Proteins) leukemia.

  8. The clinical significance of ETV6 (show ETV6 Proteins)-RUNX1.

  9. Deliver the necessary promotional drive for the progression of ETV6 (show ETV6 Proteins)-RUNX1+ pre-leukaemic cells.

  10. High RUNX1 expression is associated with pancreatic cancer.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Proteins) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Proteins) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Proteins), or cohesin subunit Smc3 (show SMC3 Proteins), fail to express runx3 (show RUNX3 Proteins) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Proteins) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt-related transcription factor 1 (runx1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 protein
  • aml protein
  • aml-1 protein
  • Aml1 protein
  • aml1-evi-1 protein
  • amlcr1 protein
  • cbfa2 protein
  • evi-1 protein
  • Pebp2a2 protein
  • pebp2ab protein
  • Pebpa2b protein
  • Runx-1 protein
  • runx1 protein
  • runxa protein
  • XAML protein
  • Xaml1 protein

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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