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Runt-Related Transcription Factor 1 Proteins (RUNX1)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Antibodies (278) and RUNX1 Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top RUNX1 Proteins at

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days

RUNX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,
Rat (Rattus)

Top referenced RUNX1 Proteins

  1. Human RUNX1 Protein expressed in Human - ABIN2731253 : Mochin, Underwood, Cooper, McLenithan, Pierce, Nalvarte, Arbiser, Karlsson, Moise, Moskovitz, Passaniti: Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. in Microvascular research 2014 (PubMed)

More Proteins for Runt-Related Transcription Factor 1 (RUNX1) Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. the Acute Myeloid Leukemia-1a (AML-1a) transcription factor, a regulator of immune gene expression, was identified as potentially sensitive to nucleosomal regulation within the Ly49 gene family. This result was confirmed in RMA, a cell line with natural expression of Ly49, using MNase-Seq to generate a nucleosome map of chromosome 6, where the Ly49 gene family is located

  2. Data show that immature Runx1-deficient CD4 (show CD4 Proteins)(+) T cells are eliminated in the periphery by the activation and fixation of the classical complement pathway.

  3. Runx1 deficiency enhanced CGRP expression and disrupted BMP4-induced neurite outgrowth inhibition in DRG.

  4. Runx1 could be manipulated after injury to promote neuronal differentiation to facilitate repair of the CNS.

  5. Runx1 haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (show CSF3 Proteins).

  6. Runx1 has an important role in Nf1 (show NF1 Proteins) neurofibroma initiation

  7. RUNX1 and ER occupy adjacent elements in AXIN1 (show AXIN1 Proteins)'s second intron, and RUNX1 antagonizes oestrogen-mediated AXIN1 (show AXIN1 Proteins) suppression.

  8. A high level of Runx1 mRNA expression was detected on days 6-8 of pregnancy and under artificial decidualization. Data suggest that Runx1 may play an important role during mouse decidualization.

  9. Results suggest that Runx1 is involved in targeting ventrocaudal hypoglossal neurons to specific muscles but is not necessary for neuronal survival, motoneuron specification, or synaptic development

  10. Setbp1 (show SETBP1 Proteins) overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. A feedback circuitry involving miR (show MLXIP Proteins)-9-1 and RUNX1-RUNX1T1 (show RUNX1T1 Proteins).

  2. The requirement for Runx1 in the normal hematopoietic development and its dysregulation through chromosomal translocations and loss-of-function mutations as found in acute myeloid leukemias highlight the importance of this transcription factor in the healthy blood system.

  3. RUNX1 is one of the most frequently mutated genes in a variety of hematological malignancies. Germ line mutations in RUNX1 cause familial platelet disorder with associated myeloid malignancies.

  4. In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2 (show NR4A2 Proteins))early growth response (EGR)2 (show EGR2 Proteins) and NR4A2EGR3. Therefore, RUNX1, NR4A2 (show NR4A2 Proteins), EGR2 (show EGR2 Proteins), EGR3 (show EGR3 Proteins) and ID4 (show ID4 Proteins) may be key genes associated with the pathogenesis of DS.

  5. Study shows that AML1 gene overexpression characterizes a broader range of leukemic subtypes than previously thought, including various maturation stages of B-cell acute lymphoblastic leukemia and cytogenetic types additional to those involving the AML1 gene.

  6. the effects of various aberrations in ETV6 (show ETV6 Proteins) and RUNX1 gene copy number on disease prognosis were evaluated in 21 pediatric patients diagnosed with B-cell ALL with/without t(12;21).

  7. The RUNX1 fusion transcript encodes a truncated protein containing the Runt homology domain responsible for both heterodimerization with CBFB (show CBFB Proteins) and DNA binding, but lacking the proline-, serine-, and threonine-rich (PST (show SULT1A1 Proteins)) region which is the transcription activation domain at the C terminal end

  8. novel RUNX1 isoforms contribute in controlling CD56 (show NCAM1 Proteins) expression in acute myeloid leukemia (show BCL11A Proteins) cells.

  9. this paper shows that RUNX1 is associated with the pathogenesis of immune thrombocytopenia possibly through regulation of Th17 cell differentiation

  10. We show that RUNX1 P1 expression is associated with colon cancer free survival suggesting a role for RUNX1 in aspirin's protective effect in colon cancer. Our studies reveal an effect of aspirin on RUNX1 and gene expression that may additionally explain aspirin's effects in cardiovascular disease and cancer.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Proteins) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Proteins) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Proteins), or cohesin subunit Smc3 (show SMC3 Proteins), fail to express runx3 (show RUNX3 Proteins) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Proteins) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1)
  • runt-related transcription factor (runt)
  • runt related transcription factor 1 (Runx1)
  • runt-related transcription factor 1 (runx1)
  • runt-related transcription factor 1 (Runx1)
  • AI462102 protein
  • aml protein
  • aml-1 protein
  • Aml1 protein
  • aml1-evi-1 protein
  • amlcr1 protein
  • cbfa2 protein
  • evi-1 protein
  • Pebp2a2 protein
  • pebp2ab protein
  • Pebpa2b protein
  • Runx-1 protein
  • runx1 protein
  • runxa protein
  • XAML protein
  • Xaml1 protein

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
Selected quality suppliers for RUNX1 Proteins (RUNX1)
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