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SAM Domain and HD Domain 1 Proteins (SAMHD1)

SAMHD1 may play a role in regulation of the innate immune response. Additionally we are shipping SAMHD1 Antibodies (111) and SAMHD1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SAMHD1 25939 Q9Y3Z3
SAMHD1 56045 Q60710
Rat SAMHD1 SAMHD1 311580  
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Top SAMHD1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

SAMHD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for SAM Domain and HD Domain 1 (SAMHD1) Interaction Partners

Human SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. This study reviewed that Neurologic Phenotypes Associated with Mutations in SAMHD1 in patients with Aicardi-Goutieres Syndrome.

  2. cytokines play a major role in the reservoir establishment not only by driving homeostatic proliferation but also by increasing susceptibility of CD4 (show CD4 Proteins)+ lymphocytes to HIV-1 infection through SAMHD1 inactivation.

  3. These observations suggest that heterozygous cancer-associated SAMHD1 mutations increase mutation rates in cancer cells.

  4. The SAMHD1 restricts HIV-1 infection in non-cycling cells by limiting the pool of deoxyribonucleoside triphosphates, thereby interfering with HIV-1 reverse transcription.

  5. Interferonstimulated gene factor 3 complex, which consists of STAT1 (show STAT1 Proteins), STAT2 (show STAT2 Proteins) and IRF9 (show IRF9 Proteins), is required for the induction of SAMHD1 expression by IFN-alpha (show IFNA Proteins) in SMMC-7721 cells.

  6. Studied whether one or more SAMHD1 gene mutations are associated with cerebrovascular disease in the general population using a Chinese stroke cohort.

  7. SAMHD1 may facilitate some aspects of THP-1 cell differentiation.

  8. Therefore, our findings revealed that factors in addition to Vpx-SAMHD1 binding influence the efficiency of Vpx-mediated SAMHD1 degradation.

  9. These results argue against a requirement for additional myeloid-specific host factors for SAMHD1 function but further support the notion that SAMHD1 possesses an additional dNTP-independent function contributing to lentiviral restriction.

  10. This review summarizes the latest advances in understanding the importance of dNTP metabolism in cancer development and the novel function of SAMHD1 in regulating this process.

Zebrafish SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. Data suggest that zebrafish may represent a system for studying the relationship between type I interferon (show IFNA Proteins) (IFN) signaling and a loss of deoxynucleoside triphosphate triphosphohydrolase SAMHD1 activity.

Mouse (Murine) SAM Domain and HD Domain 1 (SAMHD1) interaction partners

  1. These observations suggest that heterozygous cancer-associated SAMHD1 mutations increase mutation rates in cancer cells.

  2. SAMHD1 in the mouse blocks retroviral infection at the level of reverse transcription and is regulated through cell cycle-dependent phosphorylation.

  3. phosphorylation of mSAMHD1 at T634 by CDK1 (show CDK1 Proteins)/2 negatively regulates its HIV-1 restriction in differentiated cells, but does not affect its murine leukemia virus restriction in dividing cells.

  4. SAMHD1 restricts HIV-1 replication and regulates interferon (show IFNA Proteins) production in mouse myeloid cells.

  5. Allosteric regulation by dATP and dTTP works similarly in human and mouse SAMHD1.

  6. SAMHD1 decreases dNTP pool in murine cells, restricts retroviral replication and regulates type I IFN production.

  7. SAMHD1 can restrict lentiviruses in vivo and that nucleotide starvation is an evolutionarily conserved antiviral mechanism.

  8. there are several Vpx residues required for SAMHD1 degradation

  9. Vpx targets SAMHD1 for degradation in a viral strategy to control cellular deoxynucleotide levels for efficient replication

SAMHD1 Protein Profile

Protein Summary

This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.

Gene names and symbols associated with SAMHD1

  • SAM domain and HD domain 1 (SAMHD1)
  • SAM domain and HD domain 1 (samhd1)
  • SAM domain and HD domain, 1 (Samhd1)
  • CHBL2 protein
  • DCIP protein
  • E330031J07Rik protein
  • HDDC1 protein
  • Mg11 protein
  • MOP-5 protein
  • SBBI88 protein
  • si:dkeyp-44b8.8 protein

Protein level used designations for SAMHD1

SAM domain and HD domain-containing protein 1 , dNTPase , dendritic cell-derived IFNG-induced protein , deoxynucleoside triphosphate triphosphohydrolase SAMHD1 , monocyte protein 5 , SAM domain- and HD domain-containing protein 1 , IFN-gamma induced , interferon-gamma-inducible protein Mg11

GENE ID SPECIES
25939 Homo sapiens
524683 Bos taurus
419125 Gallus gallus
485862 Canis lupus familiaris
553453 Danio rerio
56045 Mus musculus
311580 Rattus norvegicus
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