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SRY (Sex Determining Region Y)-Box 2 Proteins (SOX2)

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. Additionally we are shipping SOX2 Antibodies (378) and SOX2 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat SOX2 SOX2 84491 Q6IUU3
SOX2 6657 P48431
SOX2 20674 P48432
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Top SOX2 Proteins at

Showing 10 out of 31 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 2 to 3 Days
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days

SOX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , , , ,
Mouse (Murine)

Top referenced SOX2 Proteins

  1. Human SOX2 Protein expressed in Escherichia coli (E. coli) - ABIN666968 : Wei, Yang, Zhang, Andrianakos, Hasegawa, Lyu, Chen, Bai, Liu, Pera, Lu: Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. in Stem cells (Dayton, Ohio) 2010 (PubMed)
    Show all 2 references for ABIN666968

More Proteins for SRY (Sex Determining Region Y)-Box 2 (SOX2) Interaction Partners

Human SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. SOX2 ensures pluripotent epigenetic landscapes via interacting with histone.

  2. Suggest that NKX6.3 (show NKX6-3 Proteins) might function as a master regulator of gastric differentiation by affecting SOX2 and CDX2 (show CDX2 Proteins) expression and the NKX6.3 (show NKX6-3 Proteins) inactivation may result in intestinal metaplasia in gastric epithelial cells.

  3. Both Sox2ot-7 and Sox2ot-8 are highly expressed in human cancer cell lines coinciding with SOX2, one of the pluripotency regulators.

  4. OCT4 (show POU5F1 Proteins) overexpression and loss of SOX2 expression are strongly associated with poor prognosis in patients with cervical cancer.

  5. Results demonstrate that SOX2 played a central role in promoting Ewing's sarcoma cell proliferation suggesting that it may serve as a potential biomarker.

  6. Several novel and known AKT (show AKT1 Proteins) phosphorylation sites are identified within OCT4 (show POU5F1 Proteins), SOX2 and KLF4 (show KLF4 Proteins).

  7. suggest the AKT (show AKT1 Proteins)/SOX2 molecular axis as a regulator of breast carcinoma (BC) clonogenicity and AKT (show AKT1 Proteins) inhibitors as promising drugs for the treatment of SOX2-positive BC

  8. This prompts for further studies on the mechanisms behind the TP53 (show TP53 Proteins)-induced regulation of SOX2 expression and the possible importance of hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-145 in lung cancer.

  9. OCT4 (show POU5F1 Proteins)-SOX2 configuration that dimerizes on a Hoxb1 (show HOXB1 Proteins)-like composite, a canonical element with juxtaposed individual binding sites, plays a more critical role in the induction and maintenance of pluripotency.

  10. Cancer stem cell markers are variably expressed in prostate adenocarcinoma and immunohistochemical staining for ALDH1 (show ALDH1A1 Proteins) and EZH2 (show EZH2 Proteins) may have a role in predicting tumour aggressiveness before treatment of prostate cancer

Xenopus laevis SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.

  2. Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.

  3. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  4. Suggest that SOX2 directly upregulates FGF8 (show FGF8 Proteins) gene expression in the early embryonic development of Xenopus.

  5. Continuous expression of Sox1 (show SOX1 Proteins) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.

  6. direct interaction and interdependence between the Otx2 (show OTX2 Proteins) and Sox2 proteins coordinate Rax (show RAX Proteins) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.

  7. Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2

  8. A directional Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.

Pig (Porcine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Sox2 has a role in pluripotency in pig embryos

  2. Overexpression of Sox2 or Oct4 (show POU5F1 Proteins) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Proteins) results in higher proliferation and differentiation compared to controls.

  3. cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level

Cow (Bovine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Proteins).

  2. analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos

  3. Sox2 displayed relatively the same methylation levels between sperm and oocytes

Mouse (Murine) SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. SOX2(+) stem cells initially play a significant role in contributing to postnatal pituitary gland expansion by self-renewal and differentiating into distinct lineages in the immediate postnatal period.

  2. Using photo-activatable Fluorescence Correlation Spectroscopy to quantify transcription factor-DNA binding in single cells of developing mouse embryos, study found that Sox2 long-lived binding varies between blastomeres and is regulated by H3R26 methylation.

  3. Our findings clarify that mutated SOX2-positive SCs (show TWIST1 Proteins) can underlie the pathogenesis of odontoma, through a mechanism of induction similar to embryonic odontogenesis.

  4. The REST-miR (show MLXIP Proteins)-21-Sox2 axis connects REST to the core nuclear pluripotency regulators in E14Tg2a.4 mESCs cultured in the absence of feeder cells.

  5. suggests their potential role in the maintenance of the cellular redox homeostasis in the presence of changes of SOD2 (show SOD2 Proteins) and/or p53 (show TP53 Proteins) protein levels

  6. Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.

  7. distinct interactions between Sox2 and POU-TF subclasses distinguish pluripotent ESCs (show NR2E3 Proteins) from multipotent Neural Stem Cells (NSCs), providing molecular insight into how Oct4 (show POU5F1 Proteins) alone can convert NSCs to pluripotency.

  8. Data show that Sox2 transcription factor-Cre recombinase (show RAG1 Proteins) CreER labels both supporting cells and hair cells when induced at postnatal day (P) P1.

  9. Results suggest that Oct4 (show POU5F1 Proteins) and Sox 2 transcription factors can decrease nucleosome occupancy in vivo at poised genes, but do not alter in vivo nucleosome occupancy at active genes.

  10. YAP1 (show YAP1 Proteins) regulates OCT4 (show POU5F1 Proteins) activity and SOX2 expression to facilitate self-renewal of stem-like cell

Zebrafish SRY (Sex Determining Region Y)-Box 2 (SOX2) interaction partners

  1. Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.

  2. a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury

  3. Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.

  4. significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.

  5. Knockdown of the four B1 sox (show PIPOX Proteins) genes sox2/3/19a/19b resulted in severe developmental abnormalities.

  6. sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration

  7. shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs

  8. zebrafish sox2 gene is strongly expressed in neuromast progenitor cells, including those of the migrating lateral line

  9. Sox2 overlapping transcript has multiple transcription start sites associated with genomic features that indicate regulated expression, including highly conserved elements and chromatin marks characteristic of gene promoters.

SOX2 Protein Profile

Protein Summary

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Gene names and symbols associated with SOX2

  • SRY (sex determining region Y)-box 2 (LOC100231711)
  • quiescin Q6 sulfhydryl oxidase 1 (Qsox1)
  • SRY (sex determining region Y)-box 2 (SOX2)
  • SRY (sex determining region Y)-box 2 (Sox2)
  • SRY (sex determining region Y)-box 2 (sox2)
  • SRY-box containing gene 2 (Sox2)
  • SRY-box containing gene 2 (sox2)
  • anop3 protein
  • cb236 protein
  • lcc protein
  • mcops3 protein
  • Qscn6 protein
  • Qsox protein
  • RGD1565646 protein
  • rSOx protein
  • sox-2 protein
  • SRY-box2 protein
  • wu:fb83g04 protein
  • wu:fc14d07 protein
  • Xsox-2 protein
  • ysb protein
  • zgc:65860 protein
  • zgc:77389 protein

Protein level used designations for SOX2

SRY (sex determining region Y)-box 2 , FAD-dependent sulfhydryl oxidase-2 , rQSOX , sulfhydryl oxidase 1 , SRY-related HMG-box gene 2 , transcription factor SOX-2 , transcription factor SOX2 , SRY-box containing gene 2 , Sox2 transcription factor , cSox2 , delta EF2a , XSox2 , XlSOX-2 , sex-determining region Y-box 2 , transcription factor Sox-2 , SRY-box 2 , SRY-related HMG-box 2 , sex determining region Y-box 2 , soxp

100231711 Taeniopygia guttata
84491 Rattus norvegicus
6657 Homo sapiens
499593 Rattus norvegicus
396105 Gallus gallus
488092 Canis lupus familiaris
398000 Xenopus laevis
407739 Sus scrofa
784383 Bos taurus
101110563 Ovis aries
707039 Macaca mulatta
460869 Pan troglodytes
100379629 Felis catus
100714747 Cavia porcellus
20674 Mus musculus
378723 Danio rerio
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