Selenoprotein P Proteins (SEPP1)

SEPP1 encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. Additionally we are shipping Selenoprotein P Antibodies (42) and Selenoprotein P Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SEPP1 6414 P49908
SEPP1 20363 P70274
SEPP1 29360 P25236
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Top Selenoprotein P Proteins at

Showing 8 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 6 to 10 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
HOST_Escherichia coli (E. coli) Cow GST tag   50 μg Log in to see 11 Days
Yeast Human His tag   50 μg Log in to see 8 to 11 Days

SEPP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Mouse (Murine)

Rat (Rattus)

More Proteins for Selenoprotein P (SEPP1) Interaction Partners

Human Selenoprotein P (SEPP1) interaction partners

  1. Inc (show PLXNB1 Proteins)reased amounts of circulating SeP predicted the ineffectiveness of training on endurance capacity in humans.

  2. Results indicate that the 2 genetic variants of rs7579 and rs230813 in SEPP1 may not play a role in the pathogenesis of preeclampsia in Chinese Han Women.

  3. erum microRNA-7 and selenoprotein P appear to be potential non-invasive diagnostic markers for hepatocellular carcinoma. Moreover, the results suggest that selenium could be used as an anticancer therapy for hepatocellular carcinoma by affecting both microRNA-7 and selenoprotein P

  4. The selenium levels in the tissues were correlated to the genotype of the SELENOP selenium carrier protein, but not to other proteins whose levels have been reported to be responsive to selenium availability, including GPX1 (show GPX1 Proteins), SELENOF and SBP1.

  5. GPX1 (show GPX1 Proteins) and SEPP1 Single Nucleotide Polymorphism were not associated with any changes in the expression of related genes. GPX1 (show GPX1 Proteins) was shown to modulate the expression of unrelated target, SEP15 (show SEP15 Proteins), upon Se supplementation, both alone and in combination with SEPP1.

  6. Data show that the cell proliferative ability was inhibited in the cells overexpressing selenoprotein P, plasma 1 (SEPP1), and the colony forming ability of The cell evidently decreased.

  7. Selenoprotein P concentrations are not elevated in women with gestational diabetes mellitus but are associated with BMI and HDL (show HSD11B1 Proteins) cholesterol.

  8. Studied gene-specific regulation of hepatic selenoprotein expression by interleukin-6 (show IL6 Proteins); by testing human hepatocytes in culture, found IL-6 (show IL6 Proteins) reduced the concentrations of SePP mRNA and secreted SePP in a dose-dependent manner.

  9. women who carry the SEPP1 rs3877899 A allele are better able to maintain selenium status during pregnancy, and their GPx3 (show GPX3 Proteins) activity increases more with supplementation, which suggests better protection from low selenium status.

  10. this study provide preliminary genetic evidence that the SEPP1 functional variants contribute to the AAA (show APP Proteins) risk.

Mouse (Murine) Selenoprotein P (SEPP1) interaction partners

  1. SeP (show EPHX2 Proteins) causes exercise resistance through its muscle receptor low-density lipoprotein receptor-related protein 1 (LRP1 (show LRP1 Proteins)). SeP (show EPHX2 Proteins)-deficient mice showed a 'super-endurance' phenotype after exercise training, as well as enhanced reactive oxygen species production, AMPK (show PRKAA1 Proteins) phosphorylation and Ppargc-1alpha expression in skeletal muscle.

  2. Through correlational analysis, it was determined that the effects of Se-supplement were closely related to SelP expression, inflammatory cytokines, and apoptosis molecule production.

  3. This study showed that Male mice lacking two key genes involved in Se metabolism (Scly (show SCLY Proteins)(-/-)Sepp1(-/-) mice), selenoprotein P (Sepp1) and Sec lyase (Scly (show SCLY Proteins)), develop severe neurological dysfunction, neurodegeneration, and audiogenic seizures.

  4. Results indicate that selenoprotein P (Sepp1) is important for this transport in selenium-replete mice but that glutathione peroxidase-3 (Gpx3 (show GPX3 Proteins)) is not.

  5. Sepp1 haploinsufficiency or mutations that disrupt either the selenium transport or the enzymatic domain of SEPP1 exhibit increased colitis-associated carcinogenesis via increased genomic instability and promotion of a protumorigenic microenvironment

  6. plasma Sepp1(UF) and small selenium-containing proteins are filtered by the glomerulus and taken up by PCT (show UROD Proteins) cells via megalin (show LRP2 Proteins)-mediated endocytosis.

  7. Tandem Sepp1-apoER2 (show LRP8 Proteins) interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 inside the blood-brain barrier is taken up by neurons via apoER2 (show LRP8 Proteins), concentrating brain selenium in them.

  8. These findings provide the first in vivo evidence that Scly (show SCLY Proteins) and Sepp1 work cooperatively to maintain selenoprotein function in the mammalian brain.

  9. longer isoforms of Sepp1 with high selenium content interact with a binding site distinct from the ligand-binding domain of apoER2 (show LRP8 Proteins) for selenium delivery

  10. metformin decreases binding of FoxO3a (show FOXO3 Proteins), a direct target of AMPK (show PRKAA1 Proteins), to the SEPP1 promoter.

Selenoprotein P (SEPP1) Protein Profile

Protein Summary

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.

Gene names and symbols associated with Selenoprotein P Proteins (SEPP1)

  • selenoprotein P, plasma, 1 (SEPP1)
  • selenoprotein P, plasma, 1 (sepp1)
  • selenoprotein P (SEPP1)
  • selenoprotein P (SeP)
  • selenoprotein P, plasma, 1 (Sepp1)
  • AU018766 protein
  • D15Ucla1 protein
  • DKFZp459B039 protein
  • MGC88974 protein
  • Se-P protein
  • selp protein
  • SeP protein
  • SEPP1 protein

Protein level used designations for Selenoprotein P Proteins (SEPP1)

selenoprotein P , plasma selenoprotein P , seP , selenoprotein P-like protein

431587 Gallus gallus
448755 Xenopus (Silurana) tropicalis
461897 Pan troglodytes
479346 Canis lupus familiaris
698917 Macaca mulatta
100037964 Sus scrofa
100052968 Equus caballus
100174535 Pongo abelii
100329002 Saccoglossus kowalevskii
6414 Homo sapiens
20363 Mus musculus
282066 Bos taurus
29360 Rattus norvegicus
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