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Tetraspanin 12 Proteins (TSPAN12)

The protein encoded by TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping TSPAN12 Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSPAN12 23554 O95859
Mouse TSPAN12 TSPAN12 269831 Q8BKT6
Rat TSPAN12 TSPAN12 362326 Q569A2
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Top TSPAN12 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

TSPAN12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Tetraspanin 12 (TSPAN12) Interaction Partners

Human Tetraspanin 12 (TSPAN12) interaction partners

  1. Among the patients with pathogenic mutations detected, FZD4 (show FZD4 Proteins) mutations accounted for the largest proportion of autosomal inheritance FEVR (show NDP Proteins) cases (13/18 patients, 72.2%), followed by LRP5 (show LRP5 Proteins) (4/18 patients, 22.2%) and TSPAN12 (1/18 patients, 5.6%).

  2. Here we describe a case of a female infant affected by cystic fibrosis (show S100A8 Proteins) and by a severe form of exudative vitreoretinopathy. In particular, we have detected the homozygous missense mutation c.668 T > C in TSPAN12.

  3. Novel mutation in TSPAN12 leads to autosomal recessive inheritance of congenital vitreoretinal disease with intra-familial phenotypic variability.

  4. Novel mutations have been described in the TSPAN12 gene in Chinese patients with familial exudative vitreoretinopathy.

  5. These results suggest that stroma-derived p53 (show TP53 Proteins) plays a pivotal role in epithelial cancer progression and that TSPAN12 and CXCL6 are potential targets for lung cancer therapy.

  6. TSPAN12 plays a role in supporting primary tumor growth and suppressing metastasis.

  7. This study is the first report of recessive mutations in TSPAN12 and shows that patients with two mutant alleles have a severe form of FEVR (show NDP Proteins) or retinal dysplasia, whereas heterozygous family members have mild familial exudative vitreoretinopathy phenotypes

  8. The largest miRNA-146a-TSPAN12 response to stress of amyloidbeta peptide + tumor necrosis factoralpha is found in human neuronal glial cells from Alzheimer brain.

  9. We speculate that haploinsufficiency of TSPAN12 contributes to PHPV.

  10. TSPAN12 mutations are responsible for familial exudative vitreoretinopathy (FEVR (show NDP Proteins)). The phenotypes associated with TSPAN12 mutations showed great variations between different individuals within a family and between the two eyes in individual patients.

Mouse (Murine) Tetraspanin 12 (TSPAN12) interaction partners

  1. Data indicate that Norrin (show NDP Proteins) multimers and TSPAN12 cooperatively promote multimerization of FZD4 (show FZD4 Proteins) and its associated proteins to elicit physiological levels of signaling.

TSPAN12 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Gene names and symbols associated with Tetraspanin 12 Proteins (TSPAN12)

  • tetraspanin 12 (Tspan12)
  • tetraspanin 12 (LOC100220256)
  • tetraspanin 12 (TSPAN12)
  • tetraspanin 12 (tspan12)
  • 9030619E17 protein
  • AI426782 protein
  • AI663988 protein
  • AW111457 protein
  • EVR5 protein
  • NET-2 protein
  • NET2 protein
  • Tm4sf12 protein
  • zgc:63880 protein

Protein level used designations for Tetraspanin 12 Proteins (TSPAN12)

tetraspanin 12 , tetraspanin-12 , transmembrane 4 superfamily member 12 , tspan-12 , tetraspan NET-2

412465 Apis mellifera
100220256 Taeniopygia guttata
100603513 Nomascus leucogenys
394127 Danio rerio
417763 Gallus gallus
23554 Homo sapiens
612262 Canis lupus familiaris
613639 Bos taurus
269831 Mus musculus
362326 Rattus norvegicus
100174568 Pongo abelii
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