Tetraspanin 12 Proteins (TSPAN12)

The protein encoded by TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping TSPAN12 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TSPAN12 23554 O95859
Mouse TSPAN12 TSPAN12 269831 Q8BKT6
Rat TSPAN12 TSPAN12 362326 Q569A2
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

TSPAN12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,

More Proteins for Tetraspanin 12 (TSPAN12) Interaction Partners

Human Tetraspanin 12 (TSPAN12) interaction partners

  1. Among the detected mutations, LRP5 (show LRP5 Proteins) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (show NDP Proteins) (3/31, 9.7%), FZD4 (show FZD4 Proteins) (2/31, 6.5%), TSPAN12 (1/31, 3.2%), and KIF11 (show KIF11 Proteins) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  2. FEVR (show NDP Proteins)-associated genes contributing to the disorder's autosomal dominant inheritance pattern in Korea, we determined that patients with TSPAN12 large deletions were more common than patients with single nucleotide variants in TSPAN12.

  3. TSPAN12 promotes chemoresistance and proliferation of small cell lung carcinoma under the regulation of miR (show MLXIP Proteins)-495.

  4. Several novel mutations (missense, non-stop (show USP22 Proteins) and insertion) were detected in the coding regions of FZD4 (show FZD4 Proteins), TSPAN12 and ZNF408 (show ZNF408 Proteins) genes among the unrelated vitreoretinopathy probands.The mutations in FZD4 (show FZD4 Proteins) and TSPAN12 were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in familial exudative vitreoretinopathy development.

  5. The authors report a case of familial exudative vitreoretinopathy in the spectrum of osteoporosis pseudoglioma syndrome associated with novel mutations of the LRP5 (show LRP5 Proteins) and TSPAN12 genes that resulted in a phenotype similar to bilateral persistent fetal vasculature.

  6. Among the patients with pathogenic mutations detected, FZD4 (show FZD4 Proteins) mutations accounted for the largest proportion of autosomal inheritance FEVR (show NDP Proteins) cases (13/18 patients, 72.2%), followed by LRP5 (show LRP5 Proteins) (4/18 patients, 22.2%) and TSPAN12 (1/18 patients, 5.6%).

  7. Here we describe a case of a female infant affected by cystic fibrosis (show S100A8 Proteins) and by a severe form of exudative vitreoretinopathy. In particular, we have detected the homozygous missense mutation c.668 T > C in TSPAN12.

  8. Novel mutation in TSPAN12 leads to autosomal recessive inheritance of congenital vitreoretinal disease with intra-familial phenotypic variability.

  9. Novel mutations have been described in the TSPAN12 gene in Chinese patients with familial exudative vitreoretinopathy.

  10. These results suggest that stroma-derived p53 (show TP53 Proteins) plays a pivotal role in epithelial cancer progression and that TSPAN12 and CXCL6 are potential targets for lung cancer therapy.

Mouse (Murine) Tetraspanin 12 (TSPAN12) interaction partners

  1. TSPAN12 promotes chemoresistance and proliferation of small cell lung carcinoma under the regulation of miR (show MLXIP Proteins)-495.

  2. Data indicate that Norrin (show NDP Proteins) multimers and TSPAN12 cooperatively promote multimerization of FZD4 (show FZD4 Proteins) and its associated proteins to elicit physiological levels of signaling.

TSPAN12 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Gene names and symbols associated with Tetraspanin 12 Proteins (TSPAN12)

  • tetraspanin 12 (Tspan12)
  • tetraspanin 12 (LOC100220256)
  • tetraspanin 12 (TSPAN12)
  • tetraspanin 12 (tspan12)
  • 9030619E17 protein
  • AI426782 protein
  • AI663988 protein
  • AW111457 protein
  • EVR5 protein
  • NET-2 protein
  • NET2 protein
  • Tm4sf12 protein
  • zgc:63880 protein

Protein level used designations for Tetraspanin 12 Proteins (TSPAN12)

tetraspanin 12 , tetraspanin-12 , transmembrane 4 superfamily member 12 , tspan-12 , tetraspan NET-2

412465 Apis mellifera
100220256 Taeniopygia guttata
100603513 Nomascus leucogenys
394127 Danio rerio
417763 Gallus gallus
23554 Homo sapiens
612262 Canis lupus familiaris
613639 Bos taurus
269831 Mus musculus
362326 Rattus norvegicus
100174568 Pongo abelii
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