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Transmembrane Protein 70 Proteins (TMM70)

TMM70 likely encodes a mitochondrial membrane protein. Additionally we are shipping Transmembrane Protein 70 Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TMM70 54968 Q9BUB7
TMM70 70397 Q921N7
Rat TMM70 TMM70 500384  
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Top Transmembrane Protein 70 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

TMM70 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Transmembrane Protein 70 (TMM70) Interaction Partners

Human Transmembrane Protein 70 (TMM70) interaction partners

  1. In summary, TMEM70 mutations can cause distinct ultrastructural mitochondrial degeneration and almost complete deficiency of ATP synthase but are still amenable to treatment.

  2. TMEM70 deficiency is a panethnic, multisystemic disease with variable outcome depending mainly on adequate management of hyperammonaemic crises in the neonatal period and early childhood.

  3. Pulmonary hypertension has rarely been reported in mitochondrial disorders and, so far, it has been described in association with TMEM70 deficiency only in one patient

  4. These data indicate that the biological function of TMEM70 in the ATP synthase biogenesis may be mediated through interaction with other protein(s).

  5. this study suggests that mutant TMEM70 associates in high molecular weight complexes (470-550 kDa) when expressed in Hela cells and exerts a direct action in ATP synthase biogenesis and assembly, mediating the incorporation of F1 moieties.

  6. Fibroblasts from 10 patients with TMEM70 317-2A>G homozygous mutation showed a significant 82-89% decrease of ATP synthase and 50-162% increase of respiratory chain complex IV and 22-53% increase of complex III.

  7. The authors report a fragmented mitochondrial network and swollen and irregularly shaped mitochondria with partial to complete loss of the cristae in fibroblasts of a patient with a novel TMEM70 gene deletion.

  8. TMEM70 mutations are involved in the pathogenesis of 3-methylglutaconic acid (3-MGA) acydoses in populations of different ethnic origin and become a useful genetic marker for this disease.

  9. The study identifies TMEM70 gene defect as a pan-ethnic disorder and further redefines it as the most common cause of nuclear-origin ATP synthase deficiency.

  10. Complex V TMEM70 deficiency results in mitochondrial nucleoid disorganization.

Transmembrane Protein 70 (TMM70) Protein Profile

Protein Summary

This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with TMM70

  • transmembrane protein 70 (TMEM70)
  • transmembrane protein 70 (Tmem70)
  • 1110020A09Rik protein
  • 2210416J16Rik protein
  • MC5DN2 protein
  • RGD1566224 protein

Protein level used designations for TMM70

transmembrane protein 70, mitochondrial

54968 Homo sapiens
70397 Mus musculus
500384 Rattus norvegicus
613774 Bos taurus
420188 Gallus gallus
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