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Tripartite Motif Containing 25 Proteins (TRIM25)

The protein encoded by TRIM25 is a member of the tripartite motif (TRIM) family. Additionally we are shipping TRIM25 Antibodies (132) and TRIM25 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
TRIM25 7706 Q14258
TRIM25 217069 Q61510
Rat TRIM25 TRIM25 494338  
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Top TRIM25 Proteins at

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 59 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days

TRIM25 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
Mouse (Murine)

More Proteins for Tripartite Motif Containing 25 (TRIM25) Interaction Partners

Human Tripartite Motif Containing 25 (TRIM25) interaction partners

  1. TRIM25 may exert its function through TGF-beta (show TGFB1 Proteins) pathway.

  2. TRIM25 plays an additional role in RIG-I (show DDX58 Proteins)/MDA5 (show IFIH1 Proteins) signaling other than RIG-I (show DDX58 Proteins) ubiquitination via activation of NF-kappaB (show NFKB1 Proteins).

  3. Data show that TRIM25 enhances p53 (show TP53 Proteins) and Mdm2 (show MDM2 Proteins) abundance by preventing their proteasomal degradation. At the same time, TRIM25 inhibits p53 (show TP53 Proteins)'s transcriptional activity and dampens the response to DNA damage.

  4. The PR-2B DENV-2 produced increased levels of subgenomic flavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (show RARRES3 Proteins) (RIG-I (show DDX58 Proteins))-induced type I interferon (show IFNA Proteins) expression.

  5. Trim25 binds to the conserved terminal loop (CTL) of pre-let-7 and activates TuT4 (show ZCCHC11 Proteins), allowing for more efficient Lin28a (show LIN28A Proteins)-mediated uridylation.

  6. Our data uncovers a previously unknown functional link between gp78 (show AMFR Proteins) and TRIM25 and provides mechanistic insight into gp78 (show AMFR Proteins)-mediated protein ubiquitylation.

  7. Data indicate ubiquitin-specific protease 15 (USP15 (show USP15 Proteins)) as a critical regulator of the tripartite motif protein 25 (TRIM25)- and RNA sensor retinoic acid-inducible gene-I (RIG-I (show DDX58 Proteins))-mediated antiviral immune response

  8. In controls, RNF125 (show RNF125 Proteins) is the highest expressed gene, whereas in HIV infection progressors, RIG-I (show DDX58 Proteins) is either the highest expressed gene or is expressed similarly to RNF125 (show RNF125 Proteins) and TRIM25.

  9. Study reports that RLR (show DHX58 Proteins) activation triggers MAVS (show MAVS Proteins) ubiquitination on lysine 7 and 10 by the E3 ubiquitin ligase (show MUL1 Proteins) TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling.

  10. 14-3-3epsilon is essential for the stable interaction of RIG-I (show DDX58 Proteins) with TRIM25, which facilitates RIG-I (show DDX58 Proteins) ubiquitination and initiation of innate immunity against hepatitis C virus and other pathogenic RNA viruses.

Mouse (Murine) Tripartite Motif Containing 25 (TRIM25) interaction partners

  1. Two key residues (Asp (show C3 Proteins)(488) and Trp (show TYRP1 Proteins)(621)) in the TRIM25 B30.2 domain are critical for binding to the RIG-I (show DDX58 Proteins) CARDs.

  2. Two well-known E3 ubiquitin ligases, Trim25 (also called Efp) and Trim71 (show TRIM71 Proteins) (also called Lin41 (show TRIM71 Proteins)), are validated as RNA-binding proteins, revealing a potential link between RNA biology and protein-modification pathways.

TRIM25 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.

Gene names and symbols associated with TRIM25

  • tripartite motif containing 25 (TRIM25)
  • tripartite motif-containing 25 (trim25)
  • tripartite motif containing 25 (trim25)
  • tripartite motif-containing 25 (Trim25)
  • AA960166 protein
  • AL022677 protein
  • Efp protein
  • MGC130751 protein
  • RNF147 protein
  • Z147 protein
  • Zfp147 protein
  • zgc:55773 protein
  • Znf147 protein

Protein level used designations for TRIM25

tripartite motif-containing 25 , E3 ubiquitin/ISG15 ligase TRIM25 , tripartite motif containing 25 , RING finger protein 147 , estrogen-responsive finger protein , tripartite motif protein TRIM25 , tripartite motif-containing protein 25 , ubiquitin/ISG15-conjugating enzyme TRIM25 , zinc finger protein 147 (estrogen-responsive finger protein) , zinc finger protein-147 , tripartite motif protein 25 , zinc finger protein 147

100146440 Equus caballus
393144 Danio rerio
431932 Xenopus laevis
455146 Pan troglodytes
100013883 Monodelphis domestica
100127751 Xenopus (Silurana) tropicalis
100440167 Pongo abelii
100599729 Nomascus leucogenys
7706 Homo sapiens
417401 Gallus gallus
510923 Bos taurus
491103 Canis lupus familiaris
217069 Mus musculus
494338 Rattus norvegicus
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