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PTPN22 encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. Additionally we are shipping PTPN22 Antibodies (62) and PTPN22 Kits (1) and many more products for this protein.
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Human PTPN22 Protein expressed in Wheat germ - ABIN1316837
Bayley, Yang, Buckley, Young: Measuring the specific activity of the protein tyrosine phosphatase Lyp. in Journal of immunological methods 2013
our data suggest a critical role for GITR (show TNFRSF18 Proteins) in Treg cell homeostasis and indicate that Ptpn22 independently affects the differentiation status of Treg cells and their homeostatic behavior
Tec (show NR4A3 Proteins) enhances c-Maf (show MAF Proteins)-dependent IL-4 (show IL4 Proteins) promoter activity. This effect of Tec (show NR4A3 Proteins) is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (show MAF Proteins) thereby attenuating its transcriptional activity.
lack of PTPN22 strengthens transplant tolerance to pancreatic islets by expanding both FOXP3(+) Treg and Tr1 cells
Ptpn22 and Cd2 (show CCND2 Proteins) Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes
T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases.
PTPN22 is an inhibitor of PAD-4 (show PADI4 Proteins) and protein citrullination.
Autoimmunity-associated protein tyrosine phosphatase (show ACP1 Proteins) PEP (show PREP Proteins) negatively regulates IFN-alpha (show IFNA Proteins) receptor signaling.
lack of Ptpn22 exacerbates virally-induced type 1 diabetes in lymphocytic choriomeningitis virus mice, while maintaining higher number of Treg cells in the antiviral response in the blood and spleen but not in the pancreatic lymph nodes
Data suggest that a gain-of-function of human PTPN22 transgene encoding the tyrosine phosphatase LYP is unlikely to increase risk of autoimmunity through alterations of thymic selection.
PTPN22 limited signaling via the T cell antigen receptor (TCR) by weak agonists and self antigens while not impeding responses to strong agonist antigens.
The PTPN22 1858C/T polymorphism is not associated with RA risk in Asian populations. However, our meta-analysis confirms that the PTPN22 1858C/T polymorphism is associated with RA susceptibility in Caucasians.
LPS (show IRF6 Proteins) tolerance interferes with TLR4 (show TLR4 Proteins) signaling by inhibiting Lyn (show LYN Proteins) and c-Src (show SRC Proteins) phosphorylation and their recruitment to TLR4 (show TLR4 Proteins), while increasing the phosphatase activity and expression of PP2A (show PPP2R4 Proteins), PTPN22, PTP1B (show PTPN1 Proteins) and MKP1 (show DUSP1 Proteins).
Using an integrated, unbiased genomic approach, we have identified novel genes associated with ascending aortic aneurysms in patients with bicuspid aortic valves, modulated through epigenetic mechanisms. The top gene was PTPN22, which is involved in T-cell receptor signaling and associated with various immune disorders.
sex-specific pattern of association is broadly applicable to different populations, and provides further impetus to undertake mechanistic studies to understand the impact of sex on PTPN22 in JIA.
PTPN22 gene variants were associated with type 1 diabetes susceptibility and autoimmune polyglandular syndrome type III.
Our results do not support association between PTPN22/CSK (show CSK Proteins) and Henoch-Schonlein purpura
The findings suggest that PTPN22 polymorphisms may predispose the chronicity or the development of cirrhosis and hepatocellular carcinoma in HBV infection.
The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females
rs56048322 was significantly associated with type 1 diabetes. rs56048322 affects splicing, resulting in a novel isoform of LYP which competes with the wild-type for binding to CSK (show CSK Proteins) and results in hyporesponsiveness of CD4 (show CD4 Proteins)+ T cells to antigen stimulation.
role of PTPN22 in type 1 diabetes and Crohn's disease (review
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.
PEST domain-enriched tyrosine phosphatase
, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
, protein tyrosine phosphatase, non-receptor type 8
, tyrosine-protein phosphatase non-receptor type 22
, PEST-domain phosphatase
, lymphoid phosphatase
, lymphoid-specific protein tyrosine phosphatase