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Ubiquitin Specific Peptidase 9, X-Linked Proteins (USP9X)

USP9X is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Additionally we are shipping USP9X Antibodies (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat USP9X USP9X 363445  
Mouse USP9X USP9X 22284 P70398
USP9X 8239 Q93008
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Top USP9X Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Sf-21 Cells Human His tag   25 μg Log in to see 5 to 8 Days

USP9X Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Ubiquitin Specific Peptidase 9, X-Linked (USP9X) Interaction Partners

Mouse (Murine) Ubiquitin Specific Peptidase 9, X-Linked (USP9X) interaction partners

  1. In B lymphocytes, Usp9X is required for the induction of PKCbeta kinase activity after B-Cell Antigen Receptor-dependent activation.

  2. Usp9X is a positive regulator of proximal TCR signaling in peripheral T cells and also contributes to T cell tolerance established during intrathymic development.

  3. we identified USP9X as a potential therapeutic target in prostate cancer cells and established WP1130 as a lead compound for the development of ERG (show ERG Proteins)-depleting drugs.

  4. Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta (show TGFB1 Proteins)-mediated axonogenesis.

  5. USP9X is a crucial positive regulator of the T Cell Receptor signaling pathway and is required for T-cell function through the modulation of Carma1 (show CARD11 Proteins)-Bcl10 (show BCL10 Proteins)-Malt1 (show MALT1 Proteins) complex formation.

  6. the deubiquitinase USP9X as a novel mTORC1 and -2 binding partner that negatively regulates mTOR (show FRAP1 Proteins) activity and skeletal muscle differentiation.

  7. loss of Usp9x enhances transformation and protects pancreatic cancer cells from anoikis

  8. Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.

  9. Expressed in both germ cell and supporting cell (show PTPRJ Proteins) lineages during mouse gonadal development in stage- and sex-dependent manners.

  10. Usp9x is significantly higher in the adult female mouse brains than in male brains. This implies that the difference in sex chromosome complement between XY males and XX females could potentially contribute to sexual differentiation of brain structure.

Human Ubiquitin Specific Peptidase 9, X-Linked (USP9X) interaction partners

  1. We examined the role of USP9X in the primary cilium of affected females with ciliopathy syndromes and found that endogenous USP9X localizes along the length of the ciliary axoneme, so its loss of function could disrupt cilium-regulated processes.

  2. These data support the use of MCL1 (show MCL1 Proteins) expression as a predictive biomarker for USP9X inhibitors in non-small cell lung cancer therapy

  3. The mammalian PRICKLE-interactome was defined, identifying prickle-interacting proteins that localize to synapses and a novel interacting partner, USP9X, a substrate-specific de-ubiquitinase. PRICKLE and USP9X interact through their carboxy-termini; and USP9X de-ubiquitinates PRICKLE, protecting it from proteasomal degradation.

  4. the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice.

  5. Noxa (show PMAIP1 Proteins) upregulation reduces the availability of Usp9x to Mcl-1 (show MCL1 Proteins), thereby promoting its ubiquitination and degradation, leading to the apoptosis of neoplastic cells.

  6. Although USP9X may function as a tumor-suppressor during the establishment of PDAC, data presented here argue that USP9X promotes cell growth in advanced PDAC cells when PDAC is typically diagnosed.

  7. Our analysis of clinical HCC (show FAM126A Proteins) samples verifies that miR (show MLXIP Proteins)-26b also targets USP9X expression to inhibit the EMT (show ITK Proteins) of hepatocytes

  8. USP9X downregulation renders breast cancer cells resistant to tamoxifen.

  9. USP9X mutations may have a role in X-linked intellectual disability and disrupt neuronal cell migration and growth

  10. a large set of SOX2 (show SOX2 Proteins)-associated proteins in DAOY medulloblastoma cells

USP9X Protein Profile

Protein Summary

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with USP9X

  • ubiquitin specific peptidase 9, X-linked (Usp9x)
  • ubiquitin specific peptidase 9, X-linked (USP9X)
  • ubiquitin specific peptidase 9, X-linked (usp9x)
  • ubiquitin specific peptidase 9, X chromosome (Usp9x)
  • 5730589N07Rik protein
  • AA407302 protein
  • AA407699 protein
  • AL022658 protein
  • AL022749 protein
  • DFFRX protein
  • FAF protein
  • FAF-X protein
  • Fafl protein
  • FAM protein
  • RGD1560056 protein

Protein level used designations for USP9X

probable ubiquitin carboxyl-terminal hydrolase FAF-X , ubiquitin specific peptidase 9, X chromosome , ubiquitin specific peptidase 9, X-linked , ubiquitin specific protease 9, X-linked , probable ubiquitin carboxyl-terminal hydrolase FAF-X-like , deubiquitinating enzyme FAF-X , fat facets homolog , fat facets protein-related, X-linked , fats facets protein related, X , ubiquitin carboxyl-terminal hydrolase FAM , ubiquitin specific protease 9 SSSRF- isoform , ubiquitin specific protease 9, X chromosome , ubiquitin thioesterase FAF-X , ubiquitin thiolesterase FAF-X , ubiquitin-specific protease 9, X chromosome , ubiquitin-specific-processing protease FAF-X , Drosophila fat facets related, X-linked , fat facets in mammals , fat facets protein related, X-linked , hFAM , ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila) , ubiquitin-specific processing protease FAF-X

363445 Rattus norvegicus
418569 Gallus gallus
507307 Bos taurus
480885 Canis lupus familiaris
700135 Macaca mulatta
100050489 Equus caballus
100156786 Sus scrofa
100170466 Xenopus (Silurana) tropicalis
100398696 Callithrix jacchus
100446206 Pongo abelii
100464801 Ailuropoda melanoleuca
100544793 Meleagris gallopavo
100565169 Anolis carolinensis
100587865 Nomascus leucogenys
790347 Bos taurus
22284 Mus musculus
8239 Homo sapiens
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