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anti-Vpr (HIV-1) Binding Protein (VPRBP) Antibodies

Component of the Cul4a-Rbx1-Ddb1-Vprbp/Dcaf1 E3 ubiquitin-protein ligase complex, Vprbp/Dcaf1 may function as the substrate recognition module within this complex (By similarity). Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
VPRBP 315987  
VPRBP 9730 Q9Y4B6
VPRBP 321006 Q80TR8
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Top anti-VPRBP Antibodies at

Showing 5 out of 9 products:

Catalog No. Reactivity Host Conjugate Application Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IHC, ELISA, WB 50 μL Log in to see 9 to 11 Days
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μL Log in to see 3 to 4 Days
Human Rabbit Un-conjugated 50 μL Log in to see 9 to 19 Days
Human Rabbit Un-conjugated FACS, IP, IHC, WB 200 μL Log in to see 9 to 19 Days

VPRBP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)


Mouse (Murine)

More Antibodies against VPRBP Interaction Partners

Human Vpr (HIV-1) Binding Protein (VPRBP) interaction partners

  1. VprBP transcription was repressed by cellular miRNA-1236, which contributes to HIV-1 restriction in monocytes. miR (show MLXIP Antibodies)-1236 inhibitors enhanced translation of VprBP and promoted infection. miR (show MLXIP Antibodies)-1236 mimetics suppressed translation of VprBP.

  2. MCM10 (show MCM10 Antibodies) is the natural substrate of the Cul4-DDB1 (show DDB1 Antibodies)[VprBP] E3 ubiquitin ligase (show MUL1 Antibodies) whose degradation is regulated by VprBP, but Vpr enhances the proteasomal degradation of MCM10 (show MCM10 Antibodies) by interacting with VprBP.

  3. Vpr downregulated APOBEC3G (show APOBEC3G Antibodies) through Vpr-binding protein (VprBP)-mediated proteasomal degradation, and further confirmed that the reduction of APOBEC3G (show APOBEC3G Antibodies) encapsidation associated with Vpr was due to Vpr's degradation-inducing activity.

  4. Vpr and Vpx share a highly similar DCAF1-binding motif, they interact with a different set of residues in DCAF1.

  5. VprBP, but not DDB1 (show DDB1 Antibodies), directly binds to TET2 (show TET2 Antibodies)-catalytic domain.

  6. CD44 (show CD44 Antibodies) cytoplasmic tail cleaved by RIP (show HRB Antibodies) could release DCAF1 from merlin (show NF2 Antibodies) by competing for binding to the merlin (show NF2 Antibodies) FERM domain, which results in the inhibition of merlin (show NF2 Antibodies)-mediated suppression of tumorigenesis.

  7. The identification of Vpr mutants which associate with DCAF1 but only poorly with DDB1 (show DDB1 Antibodies) suggests that DCAF1 is necessary but is not sufficient for the Vpr association with DDB1 (show DDB1 Antibodies)-containing E3 ligase complex.

  8. Data indicate that DCAF1 protein folds into a beta (show SUCLA2 Antibodies)-hairpin structure and binds to the F3 lobe of neurofibromin 2 (Merlin (show NF2 Antibodies)) FERM domain.

  9. The predicted beta-propeller conformation of DCAF1 is likely to be critical for Vpr association.

  10. NF2 (show NF2 Antibodies) loss-driven derepressed CRL4(DCAF1) promotes activation of YAP (show YAP1 Antibodies) by inhibiting hippo pathwat kinases Lats1 (show LATS1 Antibodies) and 2 in the nucleus.

Mouse (Murine) Vpr (HIV-1) Binding Protein (VPRBP) interaction partners

  1. DCAF1 is required for T-cell expansion and function during anti-viral and autoimmune responses.

  2. VprBP Is Required for Efficient Editing and Selection of Igkappa+ B Cells, but Is Dispensable for Iglambda+ and Marginal Zone B Cell Maturation (show TNFRSF17 Antibodies) and Selection

  3. CRL4(VPRBP) ubiquitin ligase is a guardian of female reproductive life in germ cells and a maternal reprogramming factor after fertilization.

  4. multi-subunit cullin RING E3 ligase complex VprBP/DDB1 (show DDB1 Antibodies)/Cul4A (show CUL4A Antibodies)/Roc1 (show RIT1 Antibodies) associates with full-length RAG1 (show RAG1 Antibodies) through VprBP

  5. Data show that human immunodeficiency virus type 1 Vpr-binding protein VprBP binds stoichiometrically with DDB1 (show DDB1 Antibodies) through its WD40 domain (show DCAF12L2 Antibodies) and through DDB1 (show DDB1 Antibodies) to CUL4A (show CUL4A Antibodies), subunits of the COP9 (show COPS8 Antibodies)/signalsome.

VPRBP Antigen Profile

Protein Summary

Component of the Cul4a-Rbx1-Ddb1-Vprbp/Dcaf1 E3 ubiquitin-protein ligase complex, Vprbp/Dcaf1 may function as the substrate recognition module within this complex (By similarity). Associated with chromatin in a Ddb1-independent and cell cycle- dependent manner, Vprbp/Dcaf1 is recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis (By similarity).

Gene names and symbols associated with VPRBP

  • Vpr (HIV-1) binding protein (Vprbp) antibody
  • Vpr (HIV-1) binding protein (VPRBP) antibody
  • Vpr (HIV-1) binding protein (vprbp) antibody
  • AI447437 antibody
  • B930007L02Rik antibody
  • DCAF1 antibody
  • mKIAA0800 antibody
  • RGD1305176 antibody

Protein level used designations for VPRBP

protein VPRBP , Vpr (HIV-1) binding protein , Vpr-binding protein , HIV-1 Vpr binding protein-like , HIV-1 Vpr binding protein , protein VPRBP-like , DDB1 and CUL4 associated factor 1 , DDB1- and CUL4-associated factor 1 , HIV-1 Vpr-binding protein , vpr-interacting protein

315987 Rattus norvegicus
415921 Gallus gallus
470820 Pan troglodytes
700596 Macaca mulatta
785711 Bos taurus
100021242 Monodelphis domestica
100061218 Equus caballus
100075187 Ornithorhynchus anatinus
100175926 Ciona intestinalis
100333081 Danio rerio
100343053 Oryctolagus cuniculus
100448638 Pongo abelii
100475880 Ailuropoda melanoleuca
100519566 Sus scrofa
100545803 Meleagris gallopavo
100565954 Anolis carolinensis
100598513 Nomascus leucogenys
9730 Homo sapiens
321006 Mus musculus
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