anti-alpha-2-Macroglobulin (A2M) Antibodies

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. Additionally we are shipping alpha 2 Macroglobulin Kits (81) and alpha 2 Macroglobulin Proteins (40) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
A2M 2 P01023
A2M 232345 Q6GQT1
A2M 24153 P06238
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Top anti-alpha 2 Macroglobulin Antibodies at

Showing 10 out of 270 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB A2M Antibody 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated EIA, WB A2M Antibody 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC, WB Host: RabbitTarget Name: A2MAntibody Dilution: 1.0ug/mlSample Tissue: Human skin 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: Alpha 2 Macroglobulin Antibody [NBP1-85491] - Lane 1: Marker [kDa] 206, 113, 82, 49, 32, 26, 18.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human cell line A-431.Lane 5: Human liver tissue.Lane 6: Human tonsil tissue Immunocytochemistry/Immunofluorescence: Alpha 2 Macroglobulin Antibody [NBP1-85491] - Immunofluorescent staining of human cell line U-251MG shows positivity in nucleoli & nucleus but not nucleoli. 0.1 mL Log in to see 10 to 13 Days
Human Goat Un-conjugated EIA, IHC (p), IP, WB 50 μL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Liver (formalin-fixed, paraffin-embedded) stained with A2Mat 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Skin, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated WB Western blot With human alpha 2 Macroglobulin antibody: Lane 1: mouse muscle lysate - 33µg Lane 2: human serum 1 µg Lane 3: Human alpha 2 Macroglobulin -2 ng Lane 4: Human alpha 2 Macroglobulin - 10 ng Lane 5: Human alpha 2 Macroglobulin - 50 ng 100 μg Log in to see 2 to 3 Days
Human Goat HRP ELISA Goat anti Alpha-2-Macroglobulin antibody () was used to detect Alpha-2-Macroglobulin under reducing (R) and non-reducing (NR) conditions. Reduced samples of purified target proteins contained 4% BME and were boiled for 5 minutes. Samples of ~1ug of protein per lane were run by SDS-PAGE. Protein was transferred to nitrocellulose and probed with 1:3000 dilution of primary antibody (ON 4 C in MB-070). Detection shown was using Dylight 649 conjugated Donkey anti goat ( 1:10K in TBS/MB-070) 1 hr RT.. 100 μg Log in to see 1 to 2 Days
Mouse Mouse Un-conjugated WB A2M Antibody (C-term)(Ascites) western blot analysis in mouse Liver tissue lysates (35ug/lane).This demonstrates the A2M antibody detected the A2M protein (arrow). 0.1 mL Log in to see 10 to 11 Days

A2M Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-alpha 2 Macroglobulin Antibodies

  1. Human Polyclonal alpha 2 Macroglobulin Primary Antibody for EIA, WB - ABIN950368 : Devreese: No more mixing tests required for integrated assay systems in the laboratory diagnosis of lupus anticoagulants? in Journal of thrombosis and haemostasis : JTH 2010 (PubMed)
    Show all 5 references for 950368

  2. Human Polyclonal alpha 2 Macroglobulin Primary Antibody for EIA, WB - ABIN950367 : Bruno, Quattrocchi, Nicoletti, Le Pira, Maci, Mostile, Andreoli, Quattrone, Zappia: Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease. in Neuroscience letters 2010 (PubMed)
    Show all 5 references for 950367

  3. Human Polyclonal alpha 2 Macroglobulin Primary Antibody for IHC, IHC (p) - ABIN4279699 : Häggmark, Neiman, Drobin, Zwahlen, Uhlén, Nilsson, Schwenk: Classification of protein profiles from antibody microarrays using heat and detergent treatment. in New biotechnology 2012 (PubMed)
    Show all 2 references for 4279699

More Antibodies against alpha 2 Macroglobulin Interaction Partners

Human alpha-2-Macroglobulin (A2M) interaction partners

  1. The plasma level of alpha2M was found positively correlated, while HCII (show SERPIND1 Antibodies) level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII (show SERPIND1 Antibodies) may be potential biomarkers for evaluation of the vulnerability of carotid ...

  2. Stabilizers during pasteurization improved alpha-2-macroglobulin (alpha2-M) activity by more than 300% points compared with the unstabilized control.

  3. Data show that low that low globulin (GLB (show DCXR Antibodies)) levels were significantly associated with favorable survival, and low ALB (show ALB Antibodies) levels were associated with a significantly worse survival .

  4. This work demonstrates that alpha2M*/CS-GRP78 (show HSPA5 Antibodies) acts as an upstream regulator of the PDK1 (show PDK1 Antibodies)/PLK1 (show PLK1 Antibodies) signaling axis to modulate c-MYC (show MYC Antibodies) transcription and its target genes, suggesting a therapeutic strategy for targeting c-MYC (show MYC Antibodies)-associated malignant progression.

  5. Meta-analysis. Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in Parkinson disease.

  6. These data demonstrate that alpha2M* and LRP1 (show LRP1 Antibodies) modulate the BKCachannel in human myometrium and that BKCaand its immunomodulatory interacting partners regulate Ca(2 (show CA2 Antibodies)+)dynamics in hMSMCs during pregnancy.

  7. we identify a single serum factor, alpha2-macroglobulin (alpha2M), which is both required and sufficient for rosetting mediated by the parasite protein P. falciparum erythrocyte membrane protein 1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins

  8. A2M is expressed in the vasculature and NR4A receptors modulate VSMC MMP2 (show MMP2 Antibodies)/9 activity by several mechanisms including the up-regulation of A2M.

  9. Data indicate that the expression of salivary alpha2 macroglobulin (alpha2-M) showed a remarkable increase in type 2 diabetes mellitus (T2DM), which may be associated with functional disorders of the salivary gland.

  10. A2M is not the only biological candidate gene for AD determination

Cow (Bovine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows.

  2. We report here for the first time the direct isolation of Spp24 (show SPP2 Antibodies) covalently bound to alpha2-macroglobulins as a core complex (Spp24 (show SPP2 Antibodies)-alpha2M) from bovine calf serum.

  3. Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis.

  4. These results suggest the possible involvement of cathepsin E (show CTSE Antibodies) in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system.

  5. Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 (show ADAMTS4 Antibodies) and ADAMTS-5 (show ADAMTS5 Antibodies)

  6. Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles.

Mouse (Murine) alpha-2-Macroglobulin (A2M) interaction partners

  1. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin (show HAMP Antibodies) remains labile and available to down-regulate Fpn1 (show SLC40A1 Antibodies).

  2. Data show that MAA-A2M adduct formation abrogated the binding of A2M bait region with TGF-beta1, trypsin, and elastase.

  3. MMP9 (show MMP9 Antibodies) production promoted by the alpha(2)M*/LRP1 (show LRP1 Antibodies) interaction required the activation of both MAPK (show MAPK1 Antibodies)-ERK1/2 (show MAPK1/3 Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling pathways.

  4. Alpha2 macroglobulin requires cyclic amp (show TMPRSS5 Antibodies) and signal transduction for cell growth

  5. Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.

  6. the 4622-base pair cDNA encodes a protein of 1473 AA with >70% sequence identity and all typical domains of other A2M-family members in humans and rodents

  7. Data describe the role of the PI3-kinase (show PIK3CA Antibodies)/PDK (show PDK2 Antibodies)/Akt (show AKT1 Antibodies)/p70s6k (show RPS6KB1 Antibodies) signaling cascade in alpha 2-macroglobulin-induced cellular proliferation and the role of CREB (show CREB1 Antibodies) in these events.

  8. review the A2M gene families of mice and humans, the predicted structural relationships between A2M and its pregnancy induced forms and the postulated roles for this gene family in normal pregnancy.

  9. the inhibition of proteases on the surface of microorganisms by an ancestral alpha2M-like thiol ester protein may generate "arrays" of oligomannose glycans to which MBL or other lectins can bind

  10. PDGF (show PDGFA Antibodies)-BB and TGF-beta1 (show TGFB1 Antibodies) binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit

Pig (Porcine) alpha-2-Macroglobulin (A2M) interaction partners

  1. Data suggest that alpha(2)-macroglobulin from serum could significantly compensate for the impaired cumulus expansion of oocytes matured in serum.

alpha 2 Macroglobulin (A2M) Antigen Profile

Protein Summary

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.

Gene names and symbols associated with A2M

  • alpha-2-macroglobulin (A2M) antibody
  • alpha-2-macroglobulin (LOC733429) antibody
  • alpha-2-macroglobulin (AZL_c00450) antibody
  • alpha-2-macroglobulin (LOC100221148) antibody
  • alpha-2-macroglobulin (LOC100224071) antibody
  • alpha-2-macroglobulin (LOC100349077) antibody
  • ovostatin (OVST) antibody
  • alpha-2-macroglobulin (a2m) antibody
  • alpha-2-macroglobulin (A2m) antibody
  • alpha-2-macroglobulin (LOC100353095) antibody
  • pregnancy-zone protein (PZP) antibody
  • A2M antibody
  • A2m1 antibody
  • A2maa antibody
  • A2MAC1 antibody
  • a2mb antibody
  • A2MD antibody
  • A2mp antibody
  • CPAMD5 antibody
  • endod antibody
  • endodermin antibody
  • FWP007 antibody
  • LOC733429 antibody
  • LOC100221148 antibody
  • LOC100224071 antibody
  • Mam antibody
  • S863-7 antibody

Protein level used designations for A2M

alpha-2-macroglobulin , alpha-2-macroglobulin-like , ovomacroglobulin, ovostatin , alpha 2m , endodermin , Alpha2-macroglobulin , alpha-2-macroglobulin b , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 , alpha-2-M , alpha-2-macroglobulin-P , pregnancy zone protein

465372 Pan troglodytes
716834 Macaca mulatta
733429 Xenopus laevis
8794592 Azospirillum sp. B510
100221148 Taeniopygia guttata
100224071 Taeniopygia guttata
100349077 Oryctolagus cuniculus
100390764 Callithrix jacchus
396151 Gallus gallus
619586 Xenopus (Silurana) tropicalis
100090399 Ornithorhynchus anatinus
100158443 Xenopus laevis
100469973 Ailuropoda melanoleuca
100595735 Nomascus leucogenys
2 Homo sapiens
100061656 Equus caballus
513856 Bos taurus
232345 Mus musculus
24153 Rattus norvegicus
100353095 Oryctolagus cuniculus
403166 Sus scrofa
477699 Canis lupus familiaris
418251 Gallus gallus
101122940 Ovis aries
101801552 Anas platyrhynchos
100173946 Pongo abelii
100153288 Sus scrofa
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